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World Journal of Emergency Surgery
Published in: World Journal of Emergency Surgery 1/2013

Open Access 01-12-2013 | Study protocol

Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients – study protocol

Authors: Hongjin Shim, Ji Young Jang, Seung Hwan Lee, Jae Gil Lee

Published in: World Journal of Emergency Surgery | Issue 1/2013

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Abstract

Background

Surgical patients who require an emergent operation commonly have severe sepsis or septic shock, followed by high morbidity and mortality rates.
Despite advances in treatment however, no predictable markers are available. In severe sepsis, many pathophysiologic mechanisms are involved in progression to organ failure, and oxygen free radical and antioxidants are known to contribute to this process. Oxygen free radical and antioxidants contribute to progression of organ failure in severe sepsis. In fact, oxygen radical activity has been reported to be correlated with disease severity and prognosis in patients with severe sepsis or septic shock. Accordingly, we aim to assess the usefulness of oxygen free radical and antioxidant concentrations to predict the disease severity and mortality in a cohort of critically ill surgical patients.

Methods/Design

This is a prospective observation study including patient demographic characteristics, clinical information, blood sampling/serum oxygen radical activity, serum antioxidant activity, serum antioxidant concentrations (zinc, selenium and glutamate), disease severity scores, outcomes, lengths of stay in intensive care unit, hospital 30-day mortality.
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Metadata
Title
Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients – study protocol
Authors
Hongjin Shim
Ji Young Jang
Seung Hwan Lee
Jae Gil Lee
Publication date
01-12-2013
Publisher
BioMed Central
Published in
World Journal of Emergency Surgery / Issue 1/2013
Electronic ISSN: 1749-7922
DOI
https://doi.org/10.1186/1749-7922-8-18

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