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Radiation Oncology
Published in: Radiation Oncology 1/2013

Open Access 01-12-2013 | Research

Paclitaxel and cisplatin combined with intensity-modulated radiotherapy for upper esophageal carcinoma

Authors: Lingli Tu, Lan Sun, Yong Xu, Yongsheng Wang, Lin Zhou, Yongmei Liu, Jiang Zhu, Feng Peng, Yuquan Wei, Youling Gong

Published in: Radiation Oncology | Issue 1/2013

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Abstract

Purpose

This study was conducted to evaluate the effectiveness and safety of intensity-modulated radiotherapy (IMRT) and concurrent paclitaxel plus cisplatin (TP regimen) for upper esophageal carcinoma.

Methods

36 patients of upper esophageal carcinoma were retrospectively analyzed. Patients were treated with IMRT (median 60 Gy) combined with concurrent TP regimen chemotherapy. The Kaplan-Meier analysis was performed in statistical analysis. Toxicities were recorded according to the NCI CTC version 3.0.

Results

36 patients aged 43–73 years (median 57 years). The median follow-up period was 14.0 months. The 1-year and 2-year survival rates were 83.3% and 42.8% respectively. The median progression-free survival (PFS) time and overall survival (OS) time were 12.0 (95% CI: 7.8–16.2 months) and 18.0 months (95% CI: 9.9–26.1 months), respectively. Grade 3 neutropenia, radiation-induced esophagitis and radiodermatitis were observed in 5 (13.9%), 3 (8.3%) and 8 (22.2%) patients respectively. There were two treatment-related deaths due to esophageal perforation and hemorrhea.

Conclusions

For those patients with upper esophageal carcinoma, IMRT combined with concurrent TP regimen chemotherapy was an effective treatment. However, more attention should be paid to the occurrence of perforation and hemorrhea.
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Metadata
Title
Paclitaxel and cisplatin combined with intensity-modulated radiotherapy for upper esophageal carcinoma
Authors
Lingli Tu
Lan Sun
Yong Xu
Yongsheng Wang
Lin Zhou
Yongmei Liu
Jiang Zhu
Feng Peng
Yuquan Wei
Youling Gong
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-8-75

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