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Radiation Oncology
Published in: Radiation Oncology 1/2013

Open Access 01-12-2013 | Research

Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century

Authors: Adam S Garden, Merrill S Kies, William H Morrison, Randal S Weber, Steven J Frank, Bonnie S Glisson, Gary B Gunn, Beth M Beadle, K Kian Ang, David I Rosenthal, Erich M Sturgis

Published in: Radiation Oncology | Issue 1/2013

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Abstract

Background

We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches.

Methods

Demographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000 – 2007 were tabulated and analyzed.

Results

The cohort consisted of 1046 patients. The 5- year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival.

Conclusions

Patients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients’ demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.
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Metadata
Title
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
Authors
Adam S Garden
Merrill S Kies
William H Morrison
Randal S Weber
Steven J Frank
Bonnie S Glisson
Gary B Gunn
Beth M Beadle
K Kian Ang
David I Rosenthal
Erich M Sturgis
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-8-21

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