Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Radiation Oncology
Published in: Radiation Oncology 1/2013

Open Access 01-12-2013 | Research

A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer

Authors: Mina Yu, Joo Hwan Lee, Hong Seok Jang, Dong Min Jeon, Jae Suk Cheon, Hyo Chun Lee, Jong Hoon Lee

Published in: Radiation Oncology | Issue 1/2013

Login to get access

Abstract

Purpose

Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.

Materials and methods

We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, VnGy, Dmin, Dmax, radiation conformality index (RCI), and radical dose homogeneity index (rDHI).

Results

The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V23.25Gy, V26.25Gy, V27.5Gy, and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.

Conclusions

Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.
Appendix
Available only for authorised users
Literature
1.
Lee EH, Lee HY, Choi KS, Jun JK, Park EC, Lee JS: Trends in cancer screening rates among Korean men and women: results from the Korean National Cancer Screening Survey (KNCSS), 2004–2010. Cancer Res Treat 2011,43(3):141-7. 10.4143/crt.2011.43.3.141CrossRefPubMedPubMedCentral
2.
Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, et al.: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004,351(17):1731-1740. 10.1056/NEJMoa040694CrossRefPubMed
3.
Bosset JF, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, et al.: Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006,355(11):1114-23. 10.1056/NEJMoa060829CrossRefPubMed
4.
Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish rectal cancer trial N Engl J Med 1997,336(14):980-987.
5.
Kapiteijn E, Marijnen CAM, Nagtegaal ID, Putter H, Steup WH, Wiggers T, et al.: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl JMed 2001,345(9):638-646. 10.1056/NEJMoa010580CrossRef
6.
Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M: Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006,93(10):1215-23. 10.1002/bjs.5506CrossRefPubMed
7.
Birgisson H, Pahlman L, Gunnarsson U, Glimelius B: Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therap y . Br J Surg 2008,95(2):206-13.CrossRefPubMed
8.
Marijnen CA, van de Velde CJ, Putter H, van den Brink M, Maas CP, Martijn H, et al.: Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2005,23(9):1847-58. 10.1200/JCO.2005.05.256CrossRefPubMed
9.
Heron DE, Gerszten K, Selvaraj RN, King GC, Sonnik D, Gallion H, et al.: Conventional 3D conformal versus intensity-modulated radiotherapy for the adjuvant treatment of gynecologic malignancies: a comparative dosimetric study of dose-volume histograms small star, filled. Gynecol Oncol 2003,91(1):39-45. 10.1016/S0090-8258(03)00461-XCrossRefPubMed
10.
Arbea L, Ramos LI, Martínez-Monge R, Moreno M, Aristu J: Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications. Radiat Oncol 2010, 5: 17. 10.1186/1748-717X-5-17CrossRefPubMedPubMedCentral
11.
International Commission on Radiation Units and Measurements: Prescribing, recording and reporting photon beam therapy ICRU report 62. Bethesda, MD: International Commission on Radiation Units and Measurements; 1999. 2010
12.
Luxton G, Hancock SL, Boyer AL: Dosimetry and radiobiologic model comparison of IMRT and 3D conformal radiotherapy in treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys 2004,59(1):267-284. 10.1016/j.ijrobp.2004.01.024CrossRefPubMed
13.
Bazan JG, Hara W, Hsu A, Kunz PA, Ford J, Fisher GA, et al.: Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal. Cancer 2011,117(15):3342-51. 10.1002/cncr.25901CrossRefPubMed
14.
National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology: anal cancer. NCCN ANAL-B 2011.
15.
Bosset JF, Meneveau N, Pavy JJ: Late intestinal complications of adjuvant radiotherapy of rectal cancers. Cancer Radiother 1997,1(16):770-4.CrossRefPubMed
16.
Lee JH, Lee JH, Jang HS, Lee HC, Lee JW, Kang DG, et al.: Hypofractionated radiotherapy with tomotherapy for patients with hepatic oligometastases: retrospective analysis of two institutions. Clin Exp Metastasis 2013,30(5):643-50. 10.1007/s10585-013-9568-7CrossRefPubMed
17.
Nuyttens JJ, Robertson JM, Yan D, Martinez A: The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int J Radiat Oncol Biol Phys 2002,53(2):497-503. 10.1016/S0360-3016(02)02753-0CrossRefPubMed
18.
Niemierko A, Goitein M: Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor. Radiother Oncol 1993,29(2):140-147. 10.1016/0167-8140(93)90239-5CrossRefPubMed
19.
Lee JH, Kim SH, Kim JG, Cho HM, Shim BY: Preoperative Chemoradiotherapy (CRT) followed by laparoscopic surgery for rectal cancer: predictors of the tumor response and the long-term oncologic outcomes. Int J Radiat Oncol Biol Phys 2011,81(2):431-8. 10.1016/j.ijrobp.2010.05.019CrossRefPubMed
20.
Lee JH, Jang HS, Kim JG, Cho HM, Shim BY, Oh ST, et al.: Lymphovascular invasion is a significant prognosticator in rectal cancer patients Who receive preoperative chemoradiotherapy followed by total mesorectal excision. Ann Surg Oncol 2012,19(4):1213-1221. 10.1245/s10434-011-2062-zCrossRefPubMed
21.
Lee JH, Kim DY, Nam TK, Yoon SC, Lee DS, Park JW, et al.: Long-term follow-up of preoperative pelvic radiotherapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04–01). Int J Radiat Oncol Biol Phys 2012,84(4):955-61. 10.1016/j.ijrobp.2012.01.045CrossRefPubMed
22.
Lee JH, Jo IY, Lee JH, Yoon SC, Kim YS, Choi BO, et al.: The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor. Radiat Oncol J 2012,30(4):205-12. 10.3857/roj.2012.30.4.205CrossRefPubMedPubMedCentral
Metadata
Title
A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer
Authors
Mina Yu
Joo Hwan Lee
Hong Seok Jang
Dong Min Jeon
Jae Suk Cheon
Hyo Chun Lee
Jong Hoon Lee
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-8-181

Other articles of this Issue 1/2013

Radiation Oncology 1/2013 Go to the issue

Research

Template-based breast IMRT planning for increased workload efficiency

Research

Correlation of dynamic changes in γ-H2AX expression in peripheral blood lymphocytes from head and neck cancer patients with radiation-induced oral mucositis

Research

Is adjuvant radiotherapy warranted in resected pT1-2 node-positive rectal cancer?

Methodology

Engineering cell-fluorescent ion track hybrid detectors

Research

Cervical necrosis after chemoradiation for cervical cancer: case series and literature review

Short report

Feasibility and accuracy of relative electron density determined by virtual monochromatic CT value subtraction at two different energies using the gemstone spectral imaging