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Radiation Oncology
Published in: Radiation Oncology 1/2012

Open Access 01-12-2012 | Research

Comparison of accelerated partial breast irradiation via multicatheter interstitial brachytherapy versus whole breast radiation

Authors: Daniel J Ferraro, Adam A Garsa, Todd A DeWees, Julie A Margenthaler, Michael Naughton, Rebecca Aft, William E Gillanders, Timothy Eberlein, Melissa A Matesa, Imran Zoberi

Published in: Radiation Oncology | Issue 1/2012

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Abstract

Background

Brachytherapy as adjuvant treatment for early-stage breast cancer has become widely available and offers patients an expedited treatment schedule. Given this, many women are electing to undergo brachytherapy in lieu of standard fractionation radiotherapy. We compare outcomes between patients treated with accelerated partial breast irradiation (APBI) via multicatheter interstitial brachytherapy versus patients who were also eligible for and offered APBI but who chose whole breast radiation (WBI).

Methods

Patients treated from December 2002 through May 2007 were reviewed. Selection criteria included patients with pTis-T2N0 disease, ≤ 3 cm unifocal tumors, and negative margins who underwent breast conservation surgery. Local control (LC), cause-specific (CSS) and overall survival (OS) were analyzed.

Results

202 patients were identified in the APBI cohort and 94 patients in the WBI cohort. Median follow-up for both groups exceeded 60 months. LC was 97.0% for the APBI cohort and 96.2% for the WBI cohort at 5 years (ns). Classification by 2010 ASTRO APBI consensus statement categories did not predict worse outcomes.

Conclusion

APBI via multicatheter interstitial brachytherapy provides similar local failure rates compared to WBI at 5 years for properly selected patients. Excellent results were seen despite the high fraction of younger patients (< 60 years old) and patients with DCIS.
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Metadata
Title
Comparison of accelerated partial breast irradiation via multicatheter interstitial brachytherapy versus whole breast radiation
Authors
Daniel J Ferraro
Adam A Garsa
Todd A DeWees
Julie A Margenthaler
Michael Naughton
Rebecca Aft
William E Gillanders
Timothy Eberlein
Melissa A Matesa
Imran Zoberi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2012
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-7-53

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