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Open Access 01-12-2011 | Research

Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Authors: Reinhard Huber, Herbert Braselmann, Hans Geinitz, Irene Jaehnert, Adolf Baumgartner, Reinhard Thamm, Markus Figel, Michael Molls, Horst Zitzelsberger

Published in: Radiation Oncology | Issue 1/2011

Abstract

Background

Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT.

Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations.

Methods

Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy.

Results

Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period.

Conclusions

The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity.

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Title: Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
Authors: Reinhard Huber
Herbert Braselmann
Hans Geinitz
Irene Jaehnert
Adolf Baumgartner
Reinhard Thamm
Markus Figel
Michael Molls
Horst Zitzelsberger
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2011
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-6-32

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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