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Radiation Oncology
Published in: Radiation Oncology 1/2009

Open Access 01-12-2009 | Research

Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis

Authors: Mohamed A Alm El-Din, Kevin S Hughes, Rita A Raad, Saveli I Goldberg, Alan C Aisenberg, Andrzej Niemierko, Alphonse G Taghian

Published in: Radiation Oncology | Issue 1/2009

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Abstract

Background

To evaluate diagnosis, management and outcome of breast cancer (BC) occurring after irradiation for Hodgkin's lymphoma (HL).

Methods

39 cases of BC in 28 HL survivors were retrospectively reviewed. 21 patients were included in a case-control analysis.

Results

The median age at diagnosis of HL and BC was 25.3 and 45.3 years, respectively. The median interval to develop BC was 16.1 years. Eleven women (39.2%) had bilateral disease. Mode of detection of the index breast cancers was by mammographic screening in 17 patients (60.7%), palpable lump in 8 patients (28.6%), clinical examination in two patients (7.1%), and unknown in one patient (3.6%). Case-control analysis showed that histological features and prognosis of BC after HL were similar to those of primary BC, however, for BC after HL, mastectomy was the predominant surgery (P = .001) and adjuvant radiotherapy and anthracycline-based chemotherapy were less frequently used as compared to primary BC (P < .001 and .003, respectively).

Conclusion

The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter.
Appendix
Available only for authorised users
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Metadata
Title
Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis
Authors
Mohamed A Alm El-Din
Kevin S Hughes
Rita A Raad
Saveli I Goldberg
Alan C Aisenberg
Andrzej Niemierko
Alphonse G Taghian
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2009
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-4-19

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