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Scoliosis and Spinal Disorders
Published in: Scoliosis and Spinal Disorders 1/2009

Open Access 01-12-2009 | Review

Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy

Authors: R Geoffrey Burwell, Ranjit K Aujla, Michael P Grevitt, Peter H Dangerfield, Alan Moulton, Tabitha L Randell, Susan I Anderson

Published in: Scoliosis and Spinal Disorders | Issue 1/2009

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Abstract

Anthropometric data from three groups of adolescent girls - preoperative adolescent idiopathic scoliosis (AIS), screened for scoliosis and normals were analysed by comparing skeletal data between higher and lower body mass index subsets. Unexpected findings for each of skeletal maturation, asymmetries and overgrowth are not explained by prevailing theories of AIS pathogenesis. A speculative pathogenetic theory for girls is formulated after surveying evidence including: (1) the thoracospinal concept for right thoracic AIS in girls; (2) the new neuroskeletal biology relating the sympathetic nervous system to bone formation/resorption and bone growth; (3) white adipose tissue storing triglycerides and the adiposity hormone leptin which functions as satiety hormone and sentinel of energy balance to the hypothalamus for long-term adiposity; and (4) central leptin resistance in obesity and possibly in healthy females. The new theory states that AIS in girls results from developmental disharmony expressed in spine and trunk between autonomic and somatic nervous systems. The autonomic component of this double neuro-osseous theory for AIS pathogenesis in girls involves selectively increased sensitivity of the hypothalamus to circulating leptin (genetically-determined up-regulation possibly involving inhibitory or sensitizing intracellular molecules, such as SOC3, PTP-1B and SH2B1 respectively), with asymmetry as an adverse response (hormesis); this asymmetry is routed bilaterally via the sympathetic nervous system to the growing axial skeleton where it may initiate the scoliosis deformity (leptin-hypothalamic-sympathetic nervous system concept = LHS concept). In some younger preoperative AIS girls, the hypothalamic up-regulation to circulating leptin also involves the somatotropic (growth hormone/IGF) axis which exaggerates the sympathetically-induced asymmetric skeletal effects and contributes to curve progression, a concept with therapeutic implications. In the somatic nervous system, dysfunction of a postural mechanism involving the CNS body schema fails to control, or may induce, the spinal deformity of AIS in girls (escalator concept). Biomechanical factors affecting ribs and/or vertebrae and spinal cord during growth may localize AIS to the thoracic spine and contribute to sagittal spinal shape alterations. The developmental disharmony in spine and trunk is compounded by any osteopenia, biomechanical spinal growth modulation, disc degeneration and platelet calmodulin dysfunction. Methods for testing the theory are outlined. Implications are discussed for neuroendocrine dysfunctions, osteopontin, sympathoactivation, medical therapy, Rett and Prader-Willi syndromes, infantile idiopathic scoliosis, and human evolution. AIS pathogenesis in girls is predicated on two putative normal mechanisms involved in trunk growth, each acquired in evolution and unique to humans.
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Literature
1.
Ebling FJP: The neuroendocrine timing of puberty. Reproduction. 2005, 129: 675-83.PubMed
2.
Kaplowitz PB: Link between body fat and the timing of puberty. Pediatrics. 2008, 121 (Supplement): S208-S217.PubMed
3.
Bandini L, Must A, Naumova E, Anderson S, Caprio S, Spadano-Gasbarro J, Dietz W: Change in leptin, body composition and other hormones around menarche - a visual representation. Acta Paediatr. 2008, 97 (10): 1454-9.PubMedPubMedCentral
4.
Goldberg CJ: Adolescent idiopathic scoliosis: is rising growth rate the triggering factor in progression?. Eur Spine J. 1993, 2: 29-36.PubMed
5.
Sanders JO, Browne RH, McConnell SJ, Margraf SA, Cooney TE, Finegold DN: Maturity assessment and curve progression in girls with idiopathic scoliosis. J Bone Joint Surg Am. 2007, 89 (1): 64-73.PubMed
6.
Grivas TB, Vasiliadis E, Mouzakis V, Mihas C, Koufopoulos G: Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes. Scoliosis. 2006, 1: 9-PubMedPubMedCentral
7.
Machida M, Dubousset J, Imamura Y, Miyashita Y, Yamada T, Kimura J: Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis. Spine. 1996, 21 (10): 1147-52.PubMed
8.
Machida M: Cause of idiopathic scoliosis. Spine. 1999, 24 (24): 2576-2583.PubMed
9.
Dubousset J, Machida M: Possible role of the pineal gland in pathogenesis of idiopathic scoliosis: experimental and clinical studies. Bull de l'Acad Nat de Méd. 2001, 185: 593-602. discussion 602-604.(French)
10.
Macchi MM, Bruce JN: Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol. 2004, 25 (3-4): 177-95.PubMed
11.
Karasek M, Winczyk K: Melatonin in humans. J Physiol Pharmacol. 2006, 57 (Suppl 5): 19-39.PubMed
12.
Molina-Carballo A, Fernández-Tardáguila E, Uberos-Fernández J, Seiquer I, Contreras-Chova F, Muñoz-Hoyos A: Longitudinal study of the simultaneous secretion of melatonin and leptin during normal puberty. Horm Res. 2007, 68 (1): 11-9.PubMed
13.
Grivas TB, Savvidou OD: Melatonin the "light of night" in human biology and adolescent idiopathic scoliosis. Scoliosis. 2007, 2: 6-PubMedPubMedCentral
14.
Moreau A, Wang DS, Forget S, Azeddine B, Angeloni D, Fraschini F, Labelle H, Poitras B, Rivard C-H, Grimard G: Melatonin signaling dysfunction in adolescent idiopathic scoliosis. Spine. 2004, 29 (16): 1772-1781.PubMed
15.
Azeddine B, Letellier K, Wang DS, Moldovan F, Moreau A: Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis. Clin Orthop Rel Res. 2007, 462: 45-52.
16.
Letellier K, Azeddine B, Blain S, Turgeon I, Wang da S, Boiro MS, Moldovan F, Labelle H, Poitras B, Rivard CH, Grimard G, Parent S, Ouellet J, Lacroix G, Moreau A: Etiopathogenesis of adolescent idiopathic scoliosis and new molecular concepts. Med Sci (Paris). 2007, 23 (11): 910-6.
17.
Moreau A, Akoumé Ndong MY, Azeddine B, Franco A, Rompré PH, Roy-Gagnon MH, Turgeon I, Wang D, Bagnall KM, Poitras B, Labelle H, Rivard CH, Grimard G, Ouellet J, Parent S, Moldovan F: Molecular and genetic aspects of idiopathic scoliosis: Blood test for idiopathic scoliosis. Orthopade. 2009, 38 (2): 114-21. (German)PubMed
18.
Moreau A, Turgeon I, Samba Boiro M, Azeddine B, Franco A, Labelle H, Poitras B, Rivard CH, Grimard G, Ouellet J, Parent S, Cheng JC, Brayda-Bruno M: Clinical valiation of a biochemical test for adolescent idiopathic scoliosis: an International Collaborative 19. Consortium [Abstract]. Eur Spine J. 2008, 17: 768-769.
19.
Moreau A, Franco A, Azeddine B, Rompré PH, Bagnall KM, Poitras B, Labelle H, Rivard C-H, Grimard G, Ouellet J, Parent S: High circulating levels of osteopontin are associated with idiopathic scoliosis onset and spinal deformity [Abstract]. Proceedings of British Scoliosis Society 33rd Annual Meeting 23rd-24th. 2009, April , in The Curve, Rutland Street, Leicester, LE1 1SB UK J Bone Joint Surg Br, Suppl in press 2009
20.
Azeddine B, Franco A, Rompré PH, Roy-Gagnon M-H, Turgeon I, Boiro MS, Blain S, Boulanger H, Wang DS, Bagnall KM, Poitras B, Labelle HLL, Rivard C-H, Grimard G, Ouellet J, Parent S, Moreau A: High circulating levels of osteopontin are associated with idiopathic scoliosis onset and spinal deformity progression [Abstract]. Proceedings of Pediatric Orthopaedic Society of North America 25th Anniversary. 2009, 109- Annual Meeting Boston, Massachusetts, April 30-May 2 2009, Boston Marriott Copley Place, p128, and In Scoliosis Research Society 44th Annual Meeting and Course, San Antonio, Texas, USA, September 23-26 2009
21.
Lowe TG, Lawellin D, Smith D, Price C, Haher T, Merola A, O'Brien M: Platelet calmodulin levels in adolescent idiopathic scoliosis. Do the levels correlate with curve progression and severity?. Spine. 2002, 27 (7): 768-775.PubMed
22.
Lowe TG, Burwell RG, Dangerfield PH: Platelet calmodulin levels in adolescent idiopathic scoliosis: can they predict curve progression and severity? Summary of an electronic focus group debate of the IBSE. Eur Spine J. 2004, 13: 257-265.PubMedPubMedCentral
23.
Enslein K, Chan DPK: Multiparameter pilot study of adolescent idiopathic scoliosis. Spine. 1987, 12 (10): 978-82.PubMed
24.
Burwell RG, Dangerfield PH, Freeman BJC: Etiologic theories of idiopathic scoliosis. Somatic nervous system and the NOTOM escalator concept as one component in the pathogenesis of adolescent idiopathic scoliosis. Stud Health Technol Inform. 2008, 140: 208-17.PubMed
25.
Burwell RG, Dangerfield PH, Moulton A, Anderson SI: Etiologic theories of idiopathic scoliosis: autonomic nervous system and the leptin-sympathetic nervous system concept for the pathogenesis of adolescent idiopathic scoliosis. Stud Health Technol Inform. 2008, 140: 197-207.PubMed
26.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Etiologic theories of idiopathic scoliosis: the leptin-hypothalamic-sympathetic nervous system (LHS) mechanism of normal trunk width growth in girls - evolutionary origin, energy allocation, motor pathways, dysfunction and pathogenesis [Abstract]. Proceedings of the International Research Society of Spinal Deformities, 9-12th. 2008, 21-July , Hope University, Everton Campus, Liverpool, UK, Abstract Book
27.
Burwell RG, Aujla RK, Dangerfield PH, Moulton A, Anderson SI: Pathogenesis of adolescent idiopathic scoliosis in girls: A battle between two nervous systems, autonomic and somatic, fought out in the spine and trunk? [Abstract]. Clin Anat. 2008, 21 (7): 746-
28.
Burwell RG, Aujla RK, Grevitt MP, Dangerfield PH, Moulton A, Anderson SI: Pathogenesis of adolescent idiopathic scoliosis in girls: a battle between two nervous systems, autonomic and somatic fought out in the spine and trunk - a theory [Abstract]. Proceedings of British Scoliosis Society Annual Meeting in conjunction with the British Scoliosis Research Foundation, 26th. 2008, September , Institute of Child Health, London WC1N 1EH, J Bone Joint Surg Br, Suppl in press 2009
29.
Burwell RG: Aetiopathogenesis of adolescent idiopathic scoliosis in girls. Disharmony between two nervous systems, somatic and autonomic, expressed in the spine and trunk. A double neuro-oseous theory [Abstract]. Magistral Lecture, ISICO Proceedings of Rachide & Rehabilitazione multidisciplinare Quinto Evidence-Based Meeting, 21st. 2009, Italian, March , Jolly Hotel, Assago, Milan, Italy, in press 2009
30.
Normelli H, Sevastik J, Akrivos J: The length and ash weight of the ribs of normal and scoliotic persons. Spine. 1985, 10 (6): 590-2.PubMed
31.
Giampietro P, Ghebranious N, Raggio CL, Ivacic L, Staubli J, McPherson E, Glurich I, Burmester J, Pauli RM, Jacobsen FS, Rasmusen KJ, Faciszewski T, Boachie-Adjei O, Blank RD: Rib length discrepancy in adolescent with idiopathic scoliosis. Scoliosis Research Society 43rd Annual Meeting and Course, Salt Lake City, Utah, USA, September 10-13. 2008, 273-
32.
Burwell RG, BJC Freeman, Dangerfield PH, Aujla RK, Cole AA, Kirby AS, Pratt RK, Webb JK, Moulton A: Left-right upper arm length asymmetry associated with apical vertebral rotation in subjects with thoracic scoliosis: anomaly of bilateral symmetry affecting vertebral, costal and upper arm physes?. Stud Health Technol Inform. 2006, 123: 66-71. and J Bone Joint Surg Br 2008, 90-B:Supp III, 476PubMed
33.
Schwender JD, Denis F: Coronal plane imbalance in adolescent idiopathic scoliosis with left lumbar curves exceeding 40°. Spine. 2000, 25 (18): 2358-63.PubMed
34.
Burwell RG, Aujla RK, Freeman BJC, Dangerfield PH, Cole AA, Kirby AS, Pratt RK, Webb JK, Moulton A: Patterns of extra-spinal left-right skeletal asymmetries in adolescent girls with lower spine scoliosis: relative lengthening of the ilium on the curve concavity and of right lower limb segments. Stud Health Technol Inform. 2006, 123: 57-65. and J Bone Joint Surg Br 2008, 90-B:Supp II, 445PubMed
35.
Burwell RG, Aujla RK, Freeman BJC, Dangerfield PH, Cole AA, Kirby AS, Pratt RK, Webb JK, Moulton A: Patterns of extra-spinal left-right skeletal asymmetries and proximo-distal disproportion in adolescent girls with lower spine scoliosis: ilio-femoral length asymmetry and bilateral tibial/foot length disproportion. Stud Health Technol Inform. 2006, 123: 101-108. and J Bone Joint Surg Br 2008; 90-B:Supp II, 445PubMed
36.
Burwell RG, Aujla RK, Grevitt MP, Dangerfield PH, Cole AA, Kirby AS, Polak FJ, Pratt RK, Moulton A, Webb JK, Anderson SI: Leptin, asymmetric bone growth, pathogenesis of adolescent idiopathic scoliosis (AIS) and hormesis: lower spine scoliosis [Abstract]. Clin Anat. 2009, 22 (3): 411-
37.
Burwell RG, Aujla RK, Freeman BJC, Cole AA, Dangerfield PH, Kirby AS, Pratt RK, Webb JK, Moulton A: Proximo-distal skeletal length disproportion in lower limbs of girls with adolescent idiopathic scoliosis compared with normal girls: tibial length/foot length is greater bilaterally and associated with left-right tibial length asymmetry [Abstract]. Clin Anat. 20 (1): 467-
38.
Burwell RG, Aujla RK, Kirby AS, Freeman BJC, Cole AA, Dangerfield PH, Polak FJ, Pratt RK, Webb JK, Moulton A: Ultrasound femoral anteversion (FAV) is decreased and asymmetric after school screening for adolescent idiopathic scoliosis (AIS): femora show torsional anomalies that if in the trunk may initiate the deformity [Abstract]. Clin Anat. 2007, 20 (7): 855-
39.
Burwell RG, Aujla RK, Kirby AS, Moulton A, Dangerfield PH, Freeman BJC, Cole AA, Polak FJ, Pratt RK, Webb JK: Ultrsound femoral anteversion (FAV) and tibial torsion (TT) after school screening for adolescent idiopathic scoliosis (AIS). Stud Health Technol Inform. 2008, 140: 225-230.PubMed
40.
Burwell RG, Aujla RK, Kirby AS, Freeman BJC, Cole AA, Dangerfield PH, Polak FJ, Pratt RK, Webb JK, Moulton A: Ultrasound femoral anteversion/tibial torsion correlations are significant, abnormal and asymmetric after school screening for adolescent scoliosis (AIS): lower limb torsional markers for initiation of the torsional trunk deformity of AIS? [Abstract]. Clin Anat. 2007, 20 (7): 855-
41.
Burwell RG, Aujla RK, Kirby AS, Moulton A, Dangerfield PH, Freeman BJC, Cole AA, Polak FJ, Pratt RK, Webb JK: Ultrasound femoral anteversion (FAV) relative to tibial torsion (TT) is abnormal after schoolscreening for adolescent idiopathic scoliosis (AIS): evaluation by two methods. Stud Health Technol Inform. 2008, 140: 37-43.PubMed
42.
Burwell RG, Aujla RK, Kirby AS, Freeman BJC, Cole AA, Dangerfield PH, Polak FJ, Pratt RK, Webb JK, Moulton A: Ultrasound tibial torsion (TT) and TT asymmetry are not abnormal after school screening for adolescent idiopathic scoliosis (AIS): in scoliosis boys TT is decreased relative to scoliosis girls without asymmetry - the result of altered maturation at knee tibial growth plates? [Abstract]. Clin Anat. 2007, 20 (7): 855-
43.
Wang S, Qiu Y, Zhu Z, Ma Z, Xia C, Zhu F: Histomorphological study of the spinal growth plates from the convex side and the concave side in adolescent idiopathic scoliosis. J Orthop Surg. 2007, 2: 19-PubMedCentral
44.
Day G, Frawley K, Phillips B, McPhee TB, Labrom R, Askin G, Mueller P: The vertebral body growth plate in scoliosis: a primary disturbance in growth?. Scoliosis. 2008, 3: 3-PubMedPubMedCentral
45.
Antoniou J, Arlet V, Goswami T, Aebi M, Alini M: Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissues. Spine. 2001, 26 (10): E198-206.PubMed
46.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Body mass index of girls in health influences menarche and skeletal maturation: a leptin-sympathetic nervous system focus on the trunk with hypothalamic asymmetric dysfunction in the pathogenesis of adolescent idiopathic scoliosis?. Stud Health Technol Inform. 2008, 140: 9-21.PubMed
47.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Relation of trunk width timing to body mass index in girls and boys - suggesting a normal developmental mechanism that arose in human evolution to conserve energy in bipedalism [Abstract]. Clin Anat. 2008, 21 (7): 746-
48.
Burwell RG, Aujla RK, Cole AA, Dangerfield PH, Moulton A: Normal adolescent boys like girls show energy priority of growth in trunk width and unlike girls also in limb segments: leptin effects, central and/or peripheral? [Abstract]. Clin Anat. 2009, 22 (3): 411-
49.
Burwell RG, Aujla RK, Randell TL, Dangerfield PH, Moulton A: At age 5-10 years in normal girls and boys, body mass index (BMI) subsets reveal energy priority of trunk width growth and in the limbs of boys: sexually dimorphic developmental mechanisms that arose in evolution with bipedalism? [Abstract]. Clin Anat. 2009, 22 (7): 855-6.
50.
Burwell RG, Aujla RK, Randell TL, Dangerfield PH, Moulton A: Normal girls age 5-10 years with relatively higher body mass index (BMI) show less skeletal growth attained than boys: evidence suggesting central leptin resistance in the somatotropic axis of juvenile girls [Abstract]. Clin Anat. 2009, 22 (7): 856-
51.
Burwell RG, Dangerfield PH, Freeman BJC: Concepts on the pathogenesis of adolescent idiopathic scoliosis. Bone growth and mass, vertebral column, spinal cord, brain, skull, extra-spinal left-right skeletal length asymmetries, disproportions and molecular pathogenesis. Stud Health Technol Inform. 2008, 135: 3-52.PubMed
52.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Freeman BJC, Cole AA, Polak FJ, Pratt RK, Webb JK: Leg-arm length ratios correlate with severity of apical vertebral rotation in girls after school screening for adolescent idiopathic scoliosis (AIS): a dynamic pathomechanism in the initiation of the deformity?. Stud Health Technol Inform. 2008, 140: 189-93.PubMed
53.
Nesse RM, Stearns SC, Omenn GS: Medicine needs evolution. Science. 2006, 311: 1071-and Nesse RM: Digesting evolution. Nature 2009, 460:461PubMed
54.
Parsons PA: Environments and evolution: interactions between stress, resource inadequacy and energetic efficiency. Biol Rev. 2005, 80: 589-610.PubMed
55.
Burt A, Trivers R: Genes in Conflict. The Biology of Selfish Genetic Elements. 2006, Cambridge, Massachusetts London, England, The Belknap Press of Harvard University Press
56.
Ward K, Nelson LM, Chettier R, Braun JT, Ogilvie JW: Genetic profile predicts curve progression in adolescent idiopathic scoliosis [Abstract]. Scoliosis Research Society 43rd Annual Meeting and Course, Salt Lake City, Utah, USA, September 10-13. 2008, 59-
57.
Nachemson AL: Future research in scoliosis. Scoliosis 1979. Edited by: Zorab PA, Siegler D. 1980, London: Academic Press, 263-270.
58.
Bagnall K: How can we achieve success in understanding the aetiology of AIS?. Stud Health Technol Inform. 2008, 135: 61-74.PubMed
59.
Sevastik J: The "thoracospinal" concept of the early development of idiopathic scoliosis. Experimental and clinical considerations. International Symposium on 3-D Scoliotic Deformities joined with the VIIth International Symposium on Spinal Deformity and Surface Topography. Edited by: Dansereau J. 1992, Ēdition de l'Ēcole Polytechnique de Montrēal:Gustav Fischer Verlag, 193-7.
60.
Sevastik B, Xiong B, Lundberg A, Sevastik JA: In vitro opto-electronic analysis of 3-D segmental vertebral movements during gradual rib lengthening in the pig. Acta Orthop Belg. 1995, 61 (3): 218-25.PubMed
61.
Sevastik JA: The thoracospinal concept of the etiopathogenesis of idiopathic scoliosis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, 14 (2): 391-400.
62.
Sevastik JA: Dysfunction of the autonomic nerve system (ANS) in the aetiopathogenesis of adolescent idiopathic scoliosis. Stud Health Technol Inform. 2002, 88: 20-3.PubMed
63.
Sevastik J, Burwell RG, Dangerfield PH: A new concept for the etiopathogenesis of the thoracospinal deformity of idiopathic scoliosis: summary of an electronic focus group debate of the IBSE. Eur Spine J. 2003, 12: 440-50.PubMedPubMedCentral
64.
Chu WCW, Man GCW, Lam WWM, Yeung BHY, Chau WW, Ng BKW, Lam T-p, Lee K-m, Cheng JCY: Morphological and functional electrophysiological evidence of relative spinal cord tethering in adolescent idiopathic scoliosis. Spine. 2008, 31: 673-80.
65.
Chu WCW, Lam WWM, Ng BKW, Lam T-p, Lee K-m, Guo X, Cheng JCY, Burwell RG, Dangerfield PH, Jaspan T: Relative shortening and functional tethering of spinal cord in adolescent scoliosis - Result of asynchronous neuro-osseous growth? Summary of an electronic focus group debate of the IBSE. Scoliosis. 2008, 3: 8-PubMedPubMedCentral
66.
Robin GC: The aetiology of idiopathic scoliosis. A review of a century of research. 1990, Boca Raton, Florida: CRC Press Inc, 1-259.
67.
Lowe TG, Edgar M, Margulies JY, Miller NH, Raso VJ, Reinker KA, Rivard C-H: Current concepts review: etiology of idiopathic scoliosis: current trends in research. J Bone Joint Surg Am. 2000, 82-A: 1157-68.PubMed
68.
Wever DJ, Veldhuizen AG, Klein JP, Webb PJ, Nijenbanning G, Cool JC, Horn JRv: A biomechanical analysis of the vertebral and rib deformities in structural scoliosis. Eur Spine J. 1999, 8: 252-60.PubMedPubMedCentral
69.
Veldhuizen AG, Wever DJ, Webb PJ: The aetiology of idiopathic scoliosis: biomechanical and neuromuscular factors. Eur Spine J. 2000, 9 (3): 178-84.PubMedPubMedCentral
70.
Burwell RG, Dangerfield PH: Adolescent idiopathic scoliosis: hypotheses of causation. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 319-333.
71.
Burwell RG: Aetiology of idiopathic scoliosis: current concepts. Pediatr Rehabil. 2003, 6 (3-4): 137-70.PubMed
72.
Parent S, Newton PO, Wenger DR: Adolescent idiopathic scoliosis: etiology, anatomy, natural history and bracing. AAOS Instructional Course Lectures. 2005, 54: 529-536.
73.
Goldberg CJ, Moore DP, Fogarty EE, Dowling FE: Scoliosis: a review. Pediatr Surg Int. 2008, 24: 129-144.PubMed
74.
Weinstein SL, Dolan LA, Cheng JC, Danielsson A, Morcuende JA: Adolescent idiopathic scoliosis. Lancet. 2008, 371 (9623): 1527-37.PubMed
75.
Kouwenhoven J-WM, Castelein RM: The pathogenesis of adolescent idiopathic scoliosis. Review of the literature. Spine. 2008, 33 (26): 2898-2908.PubMed
76.
Wang WJ, Yeung HY, Chu WC-W, Tang NL-S, Lee KM, Burwell RG, Cheng JCY: Top theories for the etiopathogenesis of adolescent idiopathic scoliosis. J Pediatr Orthop. 2009,
77.
Miller NH: Genetics of familial idiopathic scoliosis. Clin Orthop Rel Res. 2007, 462: 6-10.
78.
Cheng JC, Tang NL, Yeung HY, Miller N: Genetic association of complex traits: using idiopathic scoliosis as an example. Clin Orthop Relat Res. 2007, 462: 38-44.PubMed
79.
Gao X, Gordon D, Zhang D, Browne R, Helms C, Gillum J, Weber S, Devroy S, Swaney S, Dobbs M, Morcuende J, Sheffield V, Lovett M, Bowcock A, Herring J, Wise C: CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. Am J Hum Genet. 2007, 80 (5): 957-65.PubMedPubMedCentral
80.
Stokes IAF: Hueter-Volkmann effect. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 349-57.
81.
Stokes IAF: Analysis and simulation of progressive adolescent scoliosis by biomechanical growth modulation. Eur Spine J. 2007, 16: 1621-8.PubMedPubMedCentral
82.
Stokes IAF, Burwell RG, Dangerfield PH: Biomechanical spinal growth modulation and progressive adolescent scoliosis - a test of the 'vicious cycle' pathogenetic hypothesis: Summary of an electronic focus group debate of the IBSE. Scoliosis. 2006, 1: 16-PubMedPubMedCentral
83.
Somerville EW: Rotational lordosis: the development of a single curve. J Bone Joint Surg Br. 1952, 34-B: 421-7.PubMed
84.
Roaf R: The basic anatomy of scoliosis. J Bone Joint Surg Br. 1966, 48-B: 786-92.
85.
Deane G, Duthie RB: A new projectional look at articulated scoliotic spines. Acta Orthop Scand. 1973, 44 (4): 351-65.PubMed
86.
Neugebauer H: Scoliosis, metabolism and growth of the vertebral column. Arch Orthop Unfallchir. 1976, 85 (1): 87-99. GermanPubMed
87.
Millner PA, Dickson RA: Idiopathic scoliosis: biomechanics and biology. Eur Spine J. 1996, 5: 362-73.PubMed
88.
Cheng JCY: Osteopenia. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 339-48.
89.
Guo X, Chau W-W, Chan Y-L, Cheng J-Y-C: Relative anterior spinal overgrowth in adolescent idiopathic scoliosis. Results of disproportionate endochondral-membranous bone growth. J Bone Joint Surg Br. 2003, 85-B: 1026-31.
90.
Guo X, Chau W-W, Chan YL, Cheng J-C-Y, Burwell RG, Dangerfield PH: Relative anterior spinal overgrowth in adolescent idiopathic scoliosis - result of disproportionate endochondral-membranous bone growth? Summary of an electronic focus group debate of the IBSE. Eur Spine J. 2005, 14: 862-73.PubMed
91.
Castelein RM, van Dieën JH, Smit TH: The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis - a hypothesis. Med Hypoth. 2005, 65: 501-508.
92.
Roth M: Idiopathic scoliosis from the point of view of the neuroradiologist. Neuroradiol. 1981, 21: 133-138.
93.
94.
Lidström J, Friberg S, Lindström L, Sahlstrand T: Postural control in siblings to scoliosis patients and scoliosis patients. Spine. 1988, 3 (9): 1070-4.
95.
Edgar M: Neural mechanisms in the etiology of idiopathic scoliosis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 459-68.
96.
Williamson JB: Postural control. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 401-9.
97.
Geissele AE, Kransdorf MJ, Geyer CA, Jelinek JS, Van Dam BE: Magnetic resonance imaging of the brain stem in adolescent idiopathic scoliosis. Spine. 1991, 16 (7): 761-63.PubMed
98.
Taylor TKF: The brain stem and adolescent idiopathic scoliosis: a hypothesis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 477-81.
99.
Dretakis EK: Brain-stem dysfunction and idiopathic scoliosis. Stud Health Technol Inform. 2002, 91: 422-7.PubMed
100.
Guo X, Chau WW, Hui-Chan CWY, Cheung CSK, Tsang WWN, Cheng JCY: Balance control in adolescents with idiopathic scoliosis and disturbed somatosensory function. Spine. 2006, 31 (14): E437-40.PubMed
101.
Simoneau M, Richer N, Mercier P, Allard P, Teasdale N: Sensory deprivation and balance control in idiopathic scoliosis. Exp Brain Res. 2006, 170: 576-82.PubMed
102.
Beaulieu M, Toulotte C, Gatto L, Rivard CH, Teasdale N, Simoneau M, Allard P: Postural imbalance in non-treated adolescent idiopathic scoliosis at different periods of progression. Eur Spine J. 2009, 18 (1): 38-44.PubMed
103.
Lao ML, Chow DH, Guo X, Cheng JC, Holmes AD: Impaired dynamic balance control in adolescents with idiopathic scoliosis and abnormal somatosensory evoked potentials. J Pediatr Orthop. 2008, 28 (8): 846-9.PubMed
104.
Herman R, Mixon J, Fisher A, Maulucci R, Stuyck J: Idiopathic scoliosis and the central nervous system: a motor control problem. The Harrington Lecture, 1983. Scoliosis Research Society. Spine. 1985, 10 (1): 1-14.PubMed
105.
Burwell RG, Freeman BJC, Dangerfield PH, Aujla RK, Cole AA, Kirby AS, Polak F, Pratt RK, Webb JK, Moulton A: Neurodevelopmental concept of maturational delay of the CNS body schema ("body-in-the-brain") for adolescent idiopathic scoliosis [abstract]. J Bone Joint Surg Br. 2008, 90-B (Supp III): 476-
106.
Burwell RG, Freeman BJC, Dangerfield PH, Aujla RK, Cole AA, Kirby AS, Polak F, Pratt RK, Webb JK, Moulton A: Etiologic theories of idiopathic scoliosis: neurodevelopmental concept of maturational delay of the CNS body schema ("body-in-the-brain"). Stud Health Technol Inform. 2006, 123: 72-9. and J Bone Joint Surg Br 2008, 90-B:Supp II, 434PubMed
107.
Burwell RG, Dangerfield PH: Pathogenesis of progressive adolescent idiopathic scoliosis. Platelet activation and vascular biology in immature vertebrae: an alternative molecular hypothesis. Acta Orthop Belg. 2006, 72: 247-260.PubMed
108.
Goldberg CJ, Dowling FE, Fogarty EE, Moore DP: Adolescent idiopathic scoliosis as developmental instability. Genetica. 1995, 96 (3): 247-55.PubMed
109.
Goldberg CJ, Fogarty EE, Moore DP, Dowling FE: Scoliosis and developmental theory: adolescent idiopathic scoliosis. Spine. 1997, 22 (19): 2228-37.PubMed
110.
Goldberg CJ: Symmetry control. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 327-8. Philadelphia, Hanley & Belfus Inc
111.
Burwell RG, Dangerfield PH, Freeman BJC: Pathogenesis of adolescent idiopathic scoliosis: A collective model involving abnormality of the escalators of a normal neuro-osseous timing of maturation (NOTOM) system as the central concept [Abstract]. Clin Anat. 2008, 21 (2): 195-6.
112.
Goldberg CJ, Dowling FE, Fogarty EE, Moore DP: Adolescent idiopathic scoliosis and cerebral asymmetry. Examination of a nonspinal perceptual system. Spine. 1995, 20 (15): 1685-91.PubMed
113.
Liu T, Chu WC, Young G, Li K, Yeung BH, Guo L, Man GC, Lam WW, Wong ST, Cheng JC: MR analyses of regional brain volume in adolescent idiopathic scoliosis: neurological manifestation of a systemic disease. J Magn Reson Imaging. 2008, 27 (4): 732-6.PubMedPubMedCentral
114.
Chu W, Shi L, Wang D, Paus T, Pitiot A, Man G, Cheng A, Yeung H, Lee K, Cheng J: Anatomical difference of brains in subjects with right thoracic and left thoracic adolescent idiopathic scoliosis (AIS): MR-based morphometric study [Abstract]. J Bone Joint Surg Br. 2009, 91-B (Supp III): 429-490.
115.
Shi L, Wang D, Chu WCW, Burwell RG, Freeman BJC, Heng PA, Cheng JCY: Volume-based morphometry of brain MR images in adolescent idiopathic scoliosis and normal controls. AJNR Am J Neuroradiol. 2009, 30: 1302-PubMed
116.
Enneking WF, Harrington P: Pathological changes in scoliosis. Am. 1969, 51-A: 165-184.
117.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Trunk width growth by age is relatively earlier in girls with relatively higher than lower body mass index: adolescent idiopathic scoliosis and normals [Abstract]. Clin Anat. 2008, 21 (7): 746-
118.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Chest diameter growth by age is relatively earlier in girls with relatively higher than lower body mass index: adolescent idiopathic scoliosis and normals [Abstract]. Clin Anat. 2008, 21 (7): 745-
119.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Trunk width growth by age is relatively earlier in girls with relatively higher body mass index: hypothesis linking leptin to AIS pathogenesis [Abstract]. Proceedings of British Scoliosis Society Annual Meeting in conjunction with the British Scoliosis Research Foundation, 26th. 2008, September , Institute of Child Health, London WC1N 1EH. J Bone Joint Surg Br, Suppl in press 2009
120.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Some skeletal asymmetries in girls with adolescent idiopathic scoliosis are associated with relatively lower body mass index [Abstract]. Clin Anat. 2008, 21 (7): 746-
121.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Some skeletal asymmetries in girls with adolescent idiopathic scoliosis are associated with relatively lower body mass index: a leptin effect? [Abstract]. Proceedings of British Scoliosis Society Annual Meeting in conjunction with the British Scoliosis Research Foundation, 26th September. 2008, Institute of Child Health, London WC1N 1EH. J Bone Joint Surg Br, Suppl in press 2009
122.
Burwell RG, Aujla RK, Grevitt MP, Randell TL, Dangerfield PH, Cole AA, Kirby AS, Polak FJ, Pratt RK, Moulton A, Webb JK: Different systemic skeletal overgrowth patterns in preoperative girls with adolescent idiopathic scoliosis (AIS) revealed by higher and lower body mass index (BMI) subsets [Abstract]. Clin Anat. 2009, 22 (7): 855-
123.
Grivas TB, Vasiliadis E, Mihas C, Kaspiris A, Triandaffylopoulos G, Burwell RG: Correlation between body mass index (BMI) and trunk asymmetry in children and adolescents 5-17 years old [Abstract]. Oral presentation, 6th Hellenic Orthopaedic Research Meeting, Piraeus 28-30th. 2008, November
124.
Grivas TB, Burwell RG, Mihas C, Vasiliadis ES, Triandaffylopoulos G, Kaspiris A: Relatively lower body mass index is associated with an excess of severe truncal asymmetry in healthy adolescents. Do body fat, leptin, hypothalamus and sympathetic nervous system influence truncal growth asymmetry?. Scoliosis. 2009, 4 (1): 13-PubMedPubMedCentral
125.
Grivas TB, Burwell RG, Mihas C, Vasiliadis ES, Triandaffylopoulos G, Kaspiris A: Relatively lower body mass index is associated with an excess of severe truncal asymmetry in healthy adolescents. Do body fat, leptin, hypothalamus and sympathetic nervous system influence truncal growth asymmetry? [Abstract]. Clin Anat. 2009, 22 (7): 858-and IMAST, 16th International Meeting on Advanced Spine Techniques, Hofburg Congress Center, Vienna, Austria, July 15-18 2009
126.
Sporns O, Edelman GM: Solving Bernstein's problem: a problem for the development of coordinated movement by selection. Child Devel. 1993, 64 (4): 960-81.
127.
Gallagher S: How the body shapes the mind. 2006, Oxford: Clarendon Press, 284-
128.
Reed CL: What is the body schema?. The imitative mind, development, evolution, and brain bases. Edited by: Meltzoff AN, Prinz W. 2002, Cambridge University Press, Chapter 13: 233-43.
129.
Pelijeff A, Bonilha L, Morgan PS, McKenzie K, Jackson SR: Parietal updating of limb posture: An event-related fMRI study. Neuropschol. 2006, 44 (13): 2685-90.
130.
Blakeslee S, Blakeslee M: The body has a mind of its own: How body maps in your brain help you to do (almost) everything better. 2007, New York:Random House, 228-
131.
Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, Sasaki K: Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. 2006, 27 (11): 2738-49.
132.
Signore AP, Zhang F, Weng Z, Gao Y, Chen J: Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. J Neurochem. 2008, 106 (5): 1977-90.PubMedPubMedCentral
133.
Pannacciulli N, Del Parigi A, Chen K, Le DS, Reiman EM, Tataranni PA: Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage. 2006, 31 (4): 1419-25.PubMed
134.
Edelman GM: Learning in and from brain-based devices. Science. 2007, 318: 1103-5.PubMed
135.
Nissinen M, Heliövaara M, Seitsamo J, Poussa M: Trunk asymmetry, posture, growth, and risk of scoliosis. A three-year follow-up of Finnish prepubertal school children. Spine. 1993, 18 (1): 8-13.PubMed
136.
Hagglund G, Karlberg J, Willner S: Growth in girls with adolescent idiopathic scoliosis. Spine. 1992, 17: 108-111.PubMed
137.
Nordwall A, Willner S: A study of skeletal age and height in girls with idiopathic scoliosis. Clin Orthop. 1975, 110: 6-10.PubMed
138.
Goldberg CJ, Dowling FE, Fogarty EE: Adolescent idiopathic scoliosis- early menarche, normal growth. Spine. 1993, 18 (5): 529-35.PubMed
139.
Goldberg CJ: Skeletal growth. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 401-409.
140.
Cole AA: Anthropometry in preoperative adolescent idiopathic scoliosis. Quantitation of scoliosis before and after surgery. DM thesis. University of Nottingham, UK, Chapter 1: 12-43.
141.
Burwell RG, Aujla RK, Kirby AS, Dangerfield PH, Freeman BJC, Moulton A, Cole AA, Polak FJ, Pratt RK, Webb JK: Tibio-femoral index (TFI) of torsion: an increase with age in normal subjects but not in girls screened for scoliosis suggests earlier skeletal maturation: an ultrasound study [Abstract]. Clin Anat. 2008, 21 (2): 195-
142.
Jiang H, Greidanus N, Moreau M, Mahood J, Raso VJ, Russell G, Bagnall K: A comparison of the innervation characteristics of the lateral spinal ligaments between normal subjects and patients with adolescent idiopathic scoliosis. Acta Anat (Basel). 1997, 160 (3): 200-7.
143.
Cheng JCY, Guo X, Sher AHL: Posterior tibial nerve somatosensory cortical evoked potentials in adolescent idiopathic scoliosis. Spine. 1998, 23 (3): S332-7.
144.
Hausmann ON, Böni T, Pfirrmann CW, Curt A, Min K: Preoperative radiological and electrophysiological evaluation in 100 adolescent idiopathic scoliosis patients. Eur Spine J. 2003, 12 (5): 501-6.PubMedPubMedCentral
145.
Chu WCW, Shi L, Wang D, Paus T, Burwell RG, Man GCW, Cheng A, Yeung HY, Lee KM, Heng PA, Cheng JCY: Variations of semicircular canals orientation and left-right asymmetry in adolescent idiopathic scoliosis (AIS) comparing with normal controls: MR morphometry study using advanced image techniques. Stud Health Technol Inform. 2008, 140: 333-Also, 6th Annual World Congress for Brain Mapping and Image Guided Therap y, Annual Congress of the IBMISPS, 26-29 August 2009, Harvard Meducal School, Boston, USA
146.
Mihaila D, Calancie B: Is corticospinal tract organization different in idiopathic scoliosis? [Abstract]. Stud Health Technol Inform. 2008, 140: 350-
147.
Lafosse C, Kerckhofs E, Vereeck L, Troch M, Van Hoydonck G, Moeremans M, Sneyers C, Broeckx J, Dereymaeker L: Postural abnormalities and contraversive pushing following right hemisphere brain damage. Neuropsychol Rehabil. 2007, 17 (3): 374-96.PubMed
148.
MacNeilage PF, Rogers LJ, Vallortigara G: Origins of the left & right brain. Sci Am. 2009, 301 (1): 60-7.PubMed
149.
Burwell RG, Cole AA, Cook TA, Grivas TB, Kiel AW, Moulton A, Thirlwall AS, Upadhyay SS, Webb JK, Wemyss-Holden SA, Whitwell DJ, Wojcik AS, Wythers DJ: Pathogenesis of idiopathic scoliosis. The Nottingham concept. Acta Orthop Belg. 1992, 58: 33-58.PubMed
150.
Machida M, Dubousset J, Yamada T, Kimura J, Saito M, Shiraishi T, Yamagishi M: Experimental scoliosis in melatonin-deficient C57BL/6J mice without pinealectomy. J Pineal Res. 2006, 41 (1): 1-7.PubMed
151.
Nicolopoulos KS, Burwell RG, Webb JK: Stature and its components in adolescent idiopathic scoliosis. Cephalo-caudal disproportion in the trunk of girls. J Bone Joint Surg Br. 1985, 67 (4): 594-601.PubMed
152.
Siu King Cheung C, Tak Keung Lee W, Kit Tse Y, Ping Tang S, Man Lee K, Guo X, Qin L, Chun Yiu Cheng J: Abnormal peri-pubertal anthropometric measurements and growth pattern in adolescent idiopathic scoliosis: a study of 598 patients. Spine. 2003, 28 (18): 2152-7.PubMed
153.
Abitbol MM: Evolution of the sacrum in hominoids. Am J Phys Anthropol. 1987, 74 (1): 65-81.PubMed
154.
Boulay C, Tardieu C, Bénaim C, Hecquet J, Marty C, Prat-Pradal D, Legaye J, Duval-Beaupère G, Pélissier J: Three-dimensional study of pelvic asymmetry on anatomical specimens and its clinical perspectives. J Anat. 2006, 208 (1): 21-33.PubMedPubMedCentral
155.
Wu LP, Li YK, Li YM, Zhang YQ, Zhong SZ: Variable morphology of the sacrum in a Chinese population. Clin Anat. 2009, 22 (5): 619-26.PubMed
156.
Jebb S, Steer T, Holmes C: The 'Healthy Living' Social Market Initiative: A Review of the Evidence. MRC Human Nutrition Research. 2007, Cambridge, Department of Health, London, UK, 1-33.
157.
Shohat M, Shohat T, Nitzan M, Mimouni M, Kedem R, Danon YL: Growth and ethnicity in scoliosis. Acta Orthop Scand. 1988, 59 (3): 310-3.PubMed
158.
Cole AA, Burwell RG, Dangerfield PH, Grivas TB, Webb JK, Moulton A: Anthropometry. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 411-21.
159.
Smith FM, Latchford G, Hall RM, Millner PA, Dickson RA: Indications of disordered eating behaviour in adolescents with idiopathic scoliosis. J Bone Joint Surg Br. 2002, 84 (3): 392-394.PubMed
160.
Davey RC, Cochrane T, Dangerfield PH, Chockalingam N, Dorgan JC: Anthropometry and body composition in females with adolescent idiopathic scoliosis. International Research Society of Spinal Deformities Symposium 2004. Edited by: Sawatzky BJ. 2004, University of British Columbia, 323-326.
161.
Dangerfield PH, Davey RC, Chockalingam N, Cochrane T, Dorgan JC: Body composition in females with adolescent idiopathic scoliosis (AIS)[Abstract]. J Bone Joint Surg Br. 2005, 88-B (Supp II): 230-
162.
Cheung CSK, Lee WTK, Tse YK, Lee KM, Guo X, Qin L, Cheng JCY: Generalized osteopenia in adolescent idiopathic scoliosis: association with abnormal pubertal growth, bone turnover, and calcium intake?. Spine. 2006, 31 (2): 330-338.PubMed
163.
Qiu Y, Sun X, Qiu X, Li W, Zhu Z, Zhu F, Wang B, Yu Y, Qian B: Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis. Spine. 2007, 32 (24): 2703-2710.PubMed
164.
Sun X, Qiu Y, Qiu XS, Zhu ZZ, Zhu F, Xia CW: Association between circulating leptin level and anthropometric parameters in girls with adolescent idiopathic scoliosis. Zhonghua Yi Xue Za Zhi. 2007, 87 (9): 594-8. ChinesePubMed
165.
Barrios Pitarque C: Analysis of anthropometric findings and body composition in girls with mild or moderate scoliosis treated orthopedically [Abstract]. Eur Spine J. 2009, 18: 139-
166.
Grivas TB, Arvaniti A, Maziotou C, Manesioti M, Fergadi A: Comparison of body weight and height between normal and scoliotic children. Stud Health Technol Inform. 2002, 91: 47-53.PubMed
167.
Goldberg CJ, Moore DP, Fogartyy EE, Dowling FE: Interrelationship between Cobb angle progression, BMI and growth rate in girls with adolescent idiopathic scoliosis [Abstract]. Proceedings of British Scoliosis Society 33rd Annual Meeting 23rd-24th. 2009, April , in The Curve, Rutland Street, Leicester, LE1 1SB UK J Bone Joint Surg Br, Suppl in press 2009
168.
Smith FM, Latchford GJ, Hall RM, Dickson RA: A cross-sectional investigation of eating pathology in adolescent females with scoliosis and diabetes. Adol Health. 2008, 42 (1): 58-63.
169.
Alborghetti A, Scimeca G, Costanzo G, Boca S: The prevalence of eating disorders in adolescents with idiopathic scoliosis. Eat Disord. 2008, 16 (1): 85-93.PubMed
170.
Bruce BT, Talwalkar V, Iwinski H, Walker J, Milbrandt T: Does obesity hide adolescent idiopathic scoliosis?. Scoliosis Research Society 43rd Annual Meeting and Course, Salt Lake City, Utah, USA, September 10-13. 2008, 196-
171.
Sucato DJ, Lubicky JP, Sarwark JW: BMI is changing in children and adolescents presenting for scoliosis surgery. The Prospective Pediatric Scoliosis Database. Scoliosis Research Society 43rd Annual Meeting and Course, Salt Lake City, Utah, USA, September 10-13. 2008, 252-
172.
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008, 40 (6): 768-75.PubMedPubMedCentral
173.
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN: Genetic Investigation of ANthropometric Traits Consortium: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009, 41 (1): 25-34.PubMed
174.
Fredriksson R, Hägglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J, Schiöth HB: The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology. 2008, 149 (5): 2062-71.PubMed
175.
Timpson N, Sayers A, Davey Smith G, Tobias J: How does body fat influence bone mass in childhood? A Mendelian randomisation approach. J Bone Miner Res. 2009, 24 (3): 522-33.PubMedPubMedCentral
176.
Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U: Inactivation of the Fto gene protects from obesity. Nature. 2009, 458: 894-98.PubMed
177.
178.
Burwell RG, Patterson JF, Webb JK, Wojcik AS: School screening for scoliosis - The multiple ATI system of back shape appraisal using the Scoliometer with observations on the sagittal declive angle. Surface Topography and Body Deformity. Proceedings of the 5th International Symposium, September 29-October 1, Wien 1998. Edited by: Neugebauer H, Windischbauer G. 1990, Stuttgart: Gustav Fischer, 17-23.
179.
Hamrick MW, Pennington C, Newton D, Xie D, Isales C: Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone. 2004, 34 (3): 376-83.PubMed
180.
Kishida Y, Hirao M, Tamai N, Nampei A, Fujimoto T, Nakase T, Shimizu N, Yoshikawa H, Myoui A: Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone. 2005, 37 (5): 607-21.PubMed
181.
Perdriolle R: La Scoliose, son etude tridimensionnelle. Paris, Maloine SA. 1979
182.
Bjure J, Nachemson A: Non-treated scoliosis. Clin Orthop Rel Res. 1973, 93: 44-52.
183.
Denoel C, Ismael Aguirre MF, Bianco G, Mahaudens PH, Vanwijck R, Garson S, Sinna R, Debrun A: Idiopathic scoliosis and breast asymmetry. J Plast Reconstr Aesthet Surg. 2009, 62 (10): 1303-8.PubMed
184.
Iliopoulos P, Korovessis P, Koureas G, Zacharatos S, Stergiou P: Asymmetric evolution of anterior chest wall blood supply in female adolescents with progressive right-convex thoracic idiopathic scoliosis. Eur Spine J. 2007, 16: 1343-6.PubMedPubMedCentral
185.
Korovessis P, Iliopoulos P, Koureas G, Zacharatos S, Stergiou P: Evolution of anterior chest wall blood supply in female adolescents with progressive right-convex thoracic idiopathic scoliosis. J Spinal Disord Tech. 2007, 20 (3): 190-4.PubMed
186.
Repko M, Horký D, Krbec M, Chaloupka R, Brichtová E, Lauschová I: The role of the autonomic nervous system in the etiology of idiopathic scoliosis: prospective electron microscopic and morphometric stud. Childs Nerv Syst. 2008, 24 (2): 731-4.PubMed
187.
Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G: Leptin regulates bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000, 100: 197-200.PubMed
188.
Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G: Leptin regulates bone formation by the sympathetic nervous system. Cell. 2002, 111: 303-17.
189.
Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G: Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA. 2004, 101 (9): 3258-63.PubMedPubMedCentral
190.
Thomas T: The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol. 2004, 4: 295-300.PubMed
191.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G: Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005, 434 (7032): 514-20.PubMed
192.
Allison SJ, Baldock PA, Herzog H: The control of bone remodeling by neuropeptide Y receptors. Peptides. 2007, 28: 320-5.PubMed
193.
Crown A, Clifton DK, Steiner RA: Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinol. 2007, 86 (3): 175-182.
194.
Iwaniec UT, Boghossian S, Lapke PD, Turner RT, Kalra SP: Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides. 2007, 28 (5): 1012-9.PubMedPubMedCentral
195.
Patel MS, Elefteriou F: The new field of neuroskeletal biology. Calc Tissue Int. 2007, 80: 337-47.
196.
Elefteriou F: Regulation of bone remodeling by the central and peripheral nervous system. Arch Biochem Biophys. 2008, 473 (2): 231-6.PubMedPubMedCentral
197.
Takeda S: Central control of bone remodeling. J Neuroendocrinol. 2008, 20: 802-7.PubMed
198.
Singh MK, Elefteriou F, Karsenty G: Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Endocrinology. 2008, 149 (8): 3933-41.PubMedPubMedCentral
199.
Wiens M, Etminan M, Gill SS, Takkouche B: Effects of antihypertensive drug treatments on fracture outcomes: a meta-analysis of observational studies. J Intern Med. 2006, 260 (4): 350-62.PubMed
200.
Badman MK, Flier JS: The adipocyte as an active participant in energy balance and metabolism. Gastroenterology. 2007, 32 (6): 2103-15.
201.
Morton GJ: Hypothalamic leptin regulation of energy homeostasis and glucose metabolism. J Physiol. 2007, 583 (Pt 2): 437-43.PubMedPubMedCentral
202.
Taubes G: Insulin resistance. Prosperity's plague. Science. 2009, 325: 256-60.PubMed
203.
Ellacott KL, Halatchev IG, Cone RD: Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis. Peptides. 2006, 27 (2): 340-9.PubMed
204.
Elmquist JK: Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int J Obes Relat Metab Disord. 2001, 25 (Suppl 5): S78-82.PubMed
205.
Tseng Y-H, Kokkatou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn R: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008, 454 (7207): 1000-4.PubMedPubMedCentral
206.
Clayton PE, Gill MS, Hall CM: Serum leptin throughout childhood and adolescence. Clin Endocrinol. 1997, 46: 727-733.
207.
Demerath EW, Towne B, Wisemandle W: Serun leptin concentration, body composition, and gonadal hormones during puberty. Intern J Obesity. 23: 678-685.
208.
Gomez JM: Serum leptin, insulin-like growth factor-1 components and sex hormone binding globulin. Relationship with sex, age and body composition in healthy population. Protein and Peptide Letters. 2007, 4 (7): 701-711.
209.
Malendowicz LK, Rucinski M, Belloni AS, Ziolkowska A, Nussdorfer GG: Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. Int Rev Cytol. 2007, 263: 63-102.PubMed
210.
Ong KK, Elks CE, Li S, Zhao JH, Luan J, Andersen LB, Bingham SA, Brage S, Smith GD, Ekelund U, Gillson CJ, Glaser B, Golding J, Hardy R, Khaw KT, Kuh D, Luben R, Marcus M, McGeehin MA, Ness AR, Northstone K, Ring SM, Rubin C, Sims MA, Song K, Strachan DP, Vollenweider P, Waeber G, Waterworth DM, Wong A, Deloukas P, Barroso I, Mooser V, Loos RJ, Wareham NJ: Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet. 2009,
211.
Flanagan DE, Vaile JC, Petley GW, Phillips DI, Godsland IF, Owens P, Moore VM, Cockington RA, Robinson JS: Gender differences in the relationship between leptin, insulin resistance and the autonomic nervous system. Regul Pept. 2007, 140 (1-2): 37-42.PubMed
212.
Krishnan B, Jeffery A, Metcalf B, Hosking J, Voss L, Wilkin T, Flanagan DE: Gender differences in the relationship between heart rate control and adiposity in young children: a cross-sectional study (EarlyBird 33). Pediatr Diabetes. 2009, 10 (2): 127-34.PubMed
213.
Hamrick MW, Ferrari SL: Leptin and the sympathetic connection of fat to bone. Osteoporos Int. 2008, 19 (7): 905-12.PubMed
214.
Fu L, Patel MS, Karsenty G: The circadian modulation of leptin-controlled bone formation. Prog Brain Res. 2006, 153: 177-88.PubMed
215.
Bouxsein ML, Devlin MJ, Glatt V, Dhillon H, Pierroz DD, Ferrari SL: Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectom. Endocrinology. 2009, 150 (1): 144-52.PubMed
216.
Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G: Endocrine regulation of energy metabolism by the skeleton. Cell. 2007, 30: 456-69.
217.
Semenkovich CF, Teitelbaum SL: Bone weighs in on obesity. Cell. 2007, 130: 409-178.PubMed
218.
Wolf G: Energy regulation by the skeleton. Nutr Rev. 2008, 66 (4): 229-33.PubMed
219.
Eikelis N, Schlaich M, Aggarwal A, Kaye D, Esler M: Interactions between leptin and the human sympathetic nervous system. Hypertension. 2003, 41 (5): 1072-9.PubMed
220.
Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG: Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept. 2000, 92 (1-3): 73-8.PubMed
221.
Lee NJ, Wong IP, Baldock PA, Herzog H: Leptin as an endocrine signal in bone. Curr Osteoporos Rep. 2008, 6 (2): 62-6.PubMed
222.
Gat-Yablonski G, Phillip M: Leptin and regulation of linear growth. Curr Opin Clin Nutr Metab Care. 2008, 11 (3): 393-8.
223.
Maor G, Rochwerger M, Segev Y, Phillip M: Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res. 2002, 17 (6): 1034-43.PubMed
224.
Nakajima R, Inada H, Koike T, Yamano T: Effects of leptin to cultured growth plate chondrocytes. Horm Res. 2003, 60 (2): 91-8.PubMed
225.
226.
Vignolo M, Naselli A, Di Battista E, Mostert M, Aicardi G: Growth and development in simple obesity. Eur J Pediatr. 1988, 147 (3): 242-4.PubMed
227.
Hassink SG, Sheslow DV, de Lancey E, Opentanova I, Considine RV, Caro JF: Serum leptin in children with obesity: relationship to gender and development. Pediatrics. 1996, 98 (2 Pt 1): 201-3.PubMed
228.
Klein KO, Larmore KA, de Lancey E, Brown JM, Considine RV, Hassink SG: Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998, 83 (10): 3469-75.PubMed
229.
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997, 387 (6636): 903-8.PubMed
230.
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S: Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002, 110 (8): 1093-103.PubMedPubMedCentral
231.
Gat-Yablonski G, Shtaif B, Abraham E, Phillip M: Nutrition-induced catch-up growth at the growth plate. J Pediatr Endocrinol Metab. 2008, 21 (9): 879-93.PubMed
232.
Morris DL, Rui L: Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab. 2009,
233.
Hosoi T, Sasaki M, Miyahara T, Hashimoto C, Matsuo S, Yoshii M, Ozawa K: Endoplasmic reticulum stress induces leptin resistance. Mol Pharmacol. 2008, 74 (6): 1610-9.PubMed
234.
Mark AL, Correia ML, Rahmouni K, Haynes WG: Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens. 2002, 20 (7): 1245-50.PubMed
235.
Correia ML, Haynes WG, Rahmouni K, Morgan DA, Sivitz WI, Mark AL: The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes. 2002, 51 (2): 439-42.PubMed
236.
Rahmouni K, Morgan DA, Morgan GM, Mark AL, Haynes WG: Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes. 2005, 54 (7): 2012-8.PubMed
237.
Ladyman SR, Tups A, Augustine RA, Swahn-Azavedo AM, Kokay IC, Grattan DR: Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. J Neuroendocrinol. 2009,
238.
Tam J, Fukumura D, Jain RK: A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight. Cell Metab. 2009, 9 (1): 52-63.PubMedPubMedCentral
239.
Banks WA: The blood-brain barrier as a cause of obesity. Curr Pharm Des. 2008, 14 (16): 1606-14.PubMed
240.
White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD: HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab. 2009, 296 (2): E291-9.PubMed
241.
Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ: Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med. 2006, 12 (4): 425-32.PubMed
242.
Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, Romanatto T, Carvalheira JB, Oliveira AL, Saad MJ, Velloso LA: High-fat diet induces apoptosis of hypothalamic neurons. PLoS ONE. 2009, 4 (4): e5045-PubMedPubMedCentral
243.
Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med. 2004, 10 (7): 734-8.PubMed
244.
Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A: Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004, 10 (7): 739-43.PubMed
245.
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP: Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 1999, 283 (5407): 1544-8.PubMed
246.
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB: Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000, 20 (15): 5479-89.PubMedPubMedCentral
247.
Peelman F, Couturier C, Dam J, Zabeau L, Tavernier J, Jockers R: Techniques: new pharmacological perspectives for the leptin receptor. Trends Pharmacol Sci. 2006, 7 (4): 218-25.
248.
Couturier C, Sarkis C, Séron K, Belouzard S, Chen P, Lenain A, Corset L, Dam J, Vauthier V, Dubart A, Mallet J, Froguel P, Rouillé Y, Jockers R: Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci USA. 2007, 104 (49): 19476-81.PubMedPubMedCentral
249.
Bjørbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS: Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998, 1 (4): 619-25.PubMed
250.
Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS: Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2006, 4 (2): 123-32.PubMed
251.
Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, Kaakinen M, Laitinen J, Haukka J, Pillas D, Tzoulaki I, Molitor J, Hoggart C, Coin LJ, Whittaker J, Pouta A, Hartikainen AL, Freimer NB, Widen E, Peltonen L, Elliott P, McCarthy MI, Jarvelin MR: Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009, 5 (3): e1000409-PubMedPubMedCentral
252.
Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ: Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology. 2008, 149 (8): 3870-80.PubMedPubMedCentral
253.
Couturier C, Jockers R: Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimmers. J Biol Chem. 2003, 278 (29): 26604-11.PubMed
254.
Reinker KA: The role of melatonin and growth factors in the etiology of idiopathic scoliosi. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 431-439.
255.
Bagnall KM, Raso VJ, Hill DL, Moreau M, Mahood JK, Jiang H, Russell G, Bering M, Buzzell GR: Melatonin levels in idiopathic scoliosis. Diurnal and nocturnal serum melatonin levels in girls with adolescent idiopathic scoliosis. Spine. 1996, 21 (17): 1974-8.PubMed
256.
Letellier K, Azeddine B, Parent S, Labelle H, Rompré PH, Moreau A, Moldovan F: Estrogen cross-talk with the melatonin signaling pathway in human osteoblasts derived from adolescent idiopathic scoliosis patients. J Pineal Res. 2008, 45 (4): 383-93.PubMed
257.
Kasuya E, Kushibiki S, Sutoh M, Saito T, Ito S, Yayou K, Sakumoto R, Hodate K: Effect of melatonin injected into the third ventricle on growth hormone secretion in Holstein steers. J Vet Med Sci. 2006, 68 (10): 1075-80.PubMed
258.
Leboeuf D, Letellier K, Alos N, Edery P, Moldovan F: Do estrogens impact adolescent idiopathic scoliosis?. Trends Endocrinol Metab. 2009, 20 (4): 147-52.PubMed
259.
Lowe TG: Skeletal muscle and plartelet abnormalities in adolescent idiopathic scoliosis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 441-446.
260.
Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT: Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. J Immunol. 2009, 182 (4): 2485-91.PubMed
261.
MacDonald IF, Kempster B, Zanette L, MacDougall-Shackleton SA: Early nutritional stress impairs development of a song-control brain region in both male and female juvenile song sparrows (Melospiza melodia) at the onset of song learning. Proc Biol Sci. 2006, 273 (1600): 2559-64.PubMedPubMedCentral
262.
Fujihara S, Yokozeki M, Oba Y, Higashibata Y, Nomura S, Moriyama K: Function and regulation of osteopontin in response to mechanical stress. J Bone Miner Res. 2006, 21 (6): 956-64.PubMed
263.
Qiu XS, Tang Nl, Yeung HY, Lee KM, Hung VW, Ng BK, Ma SL, Kwok RH, Qin L, Qiu Y, Cheng JC: Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. Spine. 2007, 32 (16): 1748-1753.PubMed
264.
Qiu XS, Tang NL, Yeung HY, Cheng JC, Qiu Y: Lack of association between the promoter polymorphism of the MTNR1A gene and adolescent idiopathic scoliosis. Spine. 2008, 33 (20): 2204-7.PubMed
265.
Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L: Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009, 41 (1): 82-8.PubMed
266.
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR: Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009, 41 (1): 77-81.PubMed
267.
Schultz AH: Origin of the human stock. The specializations of man and his place among the catarrhine primates. Cold Spring Harb Symp Quant Biol. 1950, 15: 37-53.PubMed
268.
Grivas TB, Burwell RG, Purdue M, Webb JK, Moulton A: A segmental analysis of thoracic shape in chest radiographs of children. Changes related to spinal level, age, sex, side and significance for lung growth and scoliosis. J Anat. 1991, 178: 21-38.PubMedPubMedCentral
269.
Johanson DC, Edey MA, Lucy : The beginnings of human kind. London: Penguin Books, 413-
270.
Lovejoy CO: The natural history of human gait and posture. Part 1. Spine and pelvis. Gait Posture. 2005, 21 (1): 95-112.PubMed
271.
Lovejoy CO: Evolution of human walking. Sci Am. 1988, 259: 82-9.
272.
Emans JB, Ciarlo M, Callahan M, Zurakowski D: Prediction of thoracic dimensions and spine length based on individual pelvic dimensions in children and adolescents: an age-independent, individualized standard for evaluation of outcome in early onset spinal deformity. Spine. 2005, 30 (24): 2824-9.PubMed
273.
Mac-Thiong JM, Berthonnaud E, Dimar JR, Betz RR, Labelle H: Sagittal alignment of the spine and pelvis during growth. Spine. 2004, 29 (15): 1642-7.PubMed
274.
Boulay C, Tardieu C, Hecquet J, Benaim C, Mouilleseaux B, Marty C, Prat-Pradal D, Legaye J, Duval-Beaupère G, Pélissier J: Sagittal alignment of spine and pelvis regulated by pelvic incidence: standard values and prediction of lordosis. Eur Spine J. 2006, 15 (4): 415-22.PubMed
275.
Aiello L, Dean C: The hominoid pelvis. An Introduction to Human Evolutionary Anatomy. 1990, London: Academic Press, Chapter 20: 429-456.
276.
Lynch G, Granger R: The origin of big brains. Big Brain. The origins and future of human intelligence. 2008, New York; Palgrave Mcmillan, Chapter 11: 139-159.
277.
Burwell RG, Aujla RK, Cole AA, Dangerfield PH, Moulton A: Body frame size and pelvic width as a reference standard for weight? Possible biological significance and evolutionary origin [abstract]. Clin Anat. 2009, 22 (3): 410-1.
278.
Hung VWY, Qin L, Cheung CSK, Lam TP, Ng BKW, Tse YK, Go X, Lee KM, Cheng JCY: Osteopenia: a new prognostic factor of curve progression in adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2005, 87-A: 2709-2716.
279.
Szalay EA, Bosch P, Schwend RM, Buggie B, Tandberg D, Sherman F: Adolescents with idiopathic scoliosis are not osteoporotic. Spine. 2008, 33 (7): 802-6.PubMed
280.
Kauffman AS, Clifton DK, Steiner RA: Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci. 2007, 30 (10): 504-11.PubMed
281.
Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP: Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci. 2009, 29 (12): 3920-9.PubMedPubMedCentral
282.
Mattson M, Calabrese E: Best in small doses. New Sci. 2008, 199 (2668): 36-9.
283.
Mattson MP: Awareness of hormesis will enhance future research in basic and applied neuroscience. Crit Rev Toxicol. 2008, 38 (7): 633-9.PubMedPubMedCentral
284.
285.
Martin A, David V, Malaval L, Lafage-Proust MH, Vico L, Thomas T: Opposite effects of leptin on bone metabaolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway. Endocrinol. 2007, 148 (7): 3419-25.
286.
Nomura Y, Kimura K, Arai H, Segawa M: Involvement of the autonomic nervous system in the pathophysiology of Rett syndrome. Eur Child Adolesc Psychiatry. 1997, 6 (Suppl 1): 42-6.PubMed
287.
Acampa M, Guideri F, Hayek J, Blardi P, De Lalla A, Zappella M, Auteri A: Sympathetic overactivity and plasma leptin levels in Rett syndrome. Neurosci Lett. 2008, 432 (1): 69-72.PubMed
288.
Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI: Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997, 100 (2): 270-8.PubMedPubMedCentral
289.
Grugni G, Marzullo P, Ragusa L, Sartorio A, Trifirò G, Liuzzi A, Crinò A: Impairment of GH responsiveness to combined GH-releasing hormone and arginine administration in adult patients with Prader-Willi syndrome. Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetolog. Clin Endocrinol (Oxf). 2006, 65 (4): 492-9.
290.
Iughetti L, Bosio L, Corrias A, Gargantini L, Ragusa L, Livieri C, Predieri B, Bruzzi P, Caselli G, Grugni G: Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome. Eur J Pediatr. 2008, 167 (6): 701-2.PubMed
291.
Odent T, Accadbled F, Koureas G, Cournot M, Moine A, Diene G, Molinas C, Pinto G, Tauber M, Gomes B, de Gauzy JS, Glorion C: Scoliosis in patients with Prader-Willi Syndrome. Pediatrics. 2008, 122 (2): e499-503.PubMed
292.
de Lind van Wijngaarden RF, de Klerk LW, Festen DA, Hokken-Koelega AC: Scoliosis in Prader-Willi syndrome: prevalence, effects of age, gender, body mass index, lean body mass and genotype. Arch Dis Child. 2008, 93 (12): 1012-6.PubMed
293.
Diene G, de Gauzy JS, Tauber M: Is scoliosis an issue for giving growth hormone to children with Prader-Willi syndrome?. Arch Dis Child. 2008, 93 (12): 1004-6.PubMed
294.
Civardi C, Vicentini R, Grugni G, Cantello R: Corticospinal physiology in patients with Prader-Willi syndrome: a transcranial magnetic stimulation study. Arch Neurol. 2004, 61 (10): 1585-9.PubMed
295.
Myers SE, Davis A, Whitman BY, Santiago JV, Landt M: Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement. Clin Endocrinol (Oxf). 2000, 52 (1): 101-5.
296.
Haqq AM, Grambow SC, Muehlbauer M, Newgard CB, Svetkey LP, Carrel AL, Yanovski JA, Purnell JQ, Freemark M: Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. Clin Endocrinol (Oxf). 2008, 69 (6): 911-20.
297.
Proto C, Romualdi D, Cento RM, Romano C, Campagna G, Lanzone A: Free and total leptin serum levels and soluble leptin receptors levels in two models of genetic obesity: the Prader-Willi and the Down syndromes. Metabolism. 2007, 56 (8): 1076-80.PubMed
298.
Morgan E: Explaining the fat layer. The scars of evolution. What our bodies tell us about human origins. 1990, London: Souvenir Press, Ch 10: 114-123. and Not even a theory to cover our nakedness. New Sci 2009, 203(2726):28-29
299.
Kuzawa CW: Adipose tissue in human infancy and childhood: an evolutionary perspective. Am J Phys Anthropol. 1998, 177-209. Suppl 27
300.
Cunnane SC, Crawford MA: Survival of the fattest: fat babies were the key to evolution of the large human brain. Comp Biochem Physiol A Mol Integr Physiol. 2003, 136 (1): 17-26.PubMed
301.
Power Ml, Schulkin J: The evolution of obesity. 2009, Baltimore: The Johns Hopkins University Press, 392-
302.
Gluckman Beedle A, Hanson M: Principles of evolutionary medicine. 2009, Oxford: University Press, 296-
303.
Bramble DM, Lieberman DE: Endurance running and the evolution of Homo. Nature. 2004, 432 (7015): 345-52.PubMed
304.
Burton FD: Fire. The spark that ignited human evolution. 2009, Albuquerque:University of New Mexico Press, 231-
305.
Gerendai I, Halász B: Asymmetry of the neuroendocrine system. News Physiol Sci. 2001, 16: 92-5.PubMed
306.
Kasibhatla B, Wos J, Peters KG: Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes. Curr Opin Investig Drugs. 2007, 8 (10): 805-13.PubMed
307.
Skogland LB, Miller JA: Growth related hormones in idiopathic scoliosis. An endocrine basis of acceterated growth. Acta Orthop Scand. 1980, 51 (5): 779-780.PubMed
308.
Ahl T, Albertsson-Wikland K, Kalén R: Twenty-four-hour growth hormone profiles in pubertal girls with idiopathic scoliosis. Spine. 1988, 13 (2): 139-42.PubMed
309.
Kaplan SA, Cohen P: The somatomedin hypothesis 50 years later. J Clin Endocrinol Metab. 2007, 92 (12): 4529-35.PubMed
310.
Qiu XS, Tang NL, Yeung HY, Qiu Y, Cheng JC: Genetic association study of growth hormone receptor and idiopathic scoliosis. Clin Orthop Relat Res. 2007, 462: 53-8.PubMed
311.
Styne DM: The regulation of pubertal growth. Horm Res. 2003, 60 (Suppl 1): 22-6.PubMed
312.
Willner S, Nilsson KO, Kastrup K, Bergstrand CG: Growth hormone and somatomedin A in girls with adolescent idiopathic scoliosis. Acta Paediatr Scand. 1976, 65 (5): 547-52.PubMed
313.
Willner S, Johnell O: Study of biochemical and hormonal data in idiopathic scoliosis in girls. Arch Orthop Trauma Surg. 1981, 98 (4): 251-5.PubMed
314.
Yeung HY, Tang NL, Lee KM, Ng BK, Hung VW, Kwok R, Guo X, Qin L, Cheng JC: Genetic association study of insulin-like growth factor-I (IGF-I) gene with curve severity and osteopenia in adolescent idiopathic scoliosis. Stud Health Technol Inform. 2006, 123: 18-24.PubMed
315.
Dymling JF, Willner S: Progression of a structural scoliosis during treatment with growth hormone. A case report. Acta Orthop Scand. 1978, 49 (3): 264-8.PubMed
316.
Wang ED, Drummond DS, Dormans JP, Moshang T, Davidson RS, Gruccio D: Scoliosis in patients treated with growth hormon. J Pediatr Orthop. 1997, 17 (6): 708-11.PubMed
317.
Vidil A, Journeau P, Soulie A, Padovani JP, Pouliquen JC: Evolution of scoliosis in six children treated with growth hormone. J Pediatr Orthop B. 2001, 10 (3): 197-200.PubMed
318.
Docquier PL, Mousny M, Jouret M, Bastin C, Rombouts JJ: Orthopaedic concerns in children with growth hormone therapy. Acta Orthop Belg. 2004, 70 (4): 299-305.PubMed
319.
Hindmarsh PC, Pringle PJ, Stanhope R, Brook CG: The effect of a continuous infusion of a somatostatin analogue (octreotide) for two years on growth hormone secretion and height prediction in tall childre. Clin Endocrinol. 1995, 42 (5): 509-15.
320.
Nagai T, Obata K, Ogata T, Murakami N, Katada Y, Yoshino A, Sakazume S, Tomita Y, Sakuta R, Niikawa N: Growth hormone therapy and scoliosis in patients with Prader-Willi syndrome. Am J Med Genet. 2006, 140 (15): 1623-7.PubMed
321.
de Lind van Wijngaarden R, de Klerk LW, Festen DA, Otten BJ, Hokken-Koelega AC: Scoliosis and the effects of growth hormone treatment in children with Prader-Willi syndrome. Scoliosis Research Society 43rd Annual Meeting and Course, Salt Lake City, Utah, USA, September 10-13. 2008, 109-
322.
Neugebauer H: Brace and hormone therapy of idiopathic scolioses. Report of a 6-year investigation. Wien Klin Wochenschr Suppl. 1974, 22: 3-30.PubMed
323.
Drop SL, De Waal WJ, De Muinck Keizer-Schrama SM: Sex steroid treatment of constitutionally tall stature. Endocr Rev. 1998, 19 (5): 540-58.PubMed
324.
Inoue M, Minami S, Nakata Y, Kitahara H, Otsuka Y, Isobe K, Takaso M, Tokunaga M, Nishikawa S, Maruta T, Moriya H: Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis. Spine (Phila Pa 1976). 2002, 27 (21): 2357-62.
325.
Wu J, Qiu Y, Zhang L, Sun Q, Qiu X, He Y: Association of estrogen receptor gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2006, 31 (10): 1131-6.
326.
Zhang HQ, Lu SJ, Tang MX, Chen LQ, Liu SH, Guo CF, Wang XY, Chen J, Xie L: Association of estrogen receptor beta gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2009, 34 (8): 760-4.
327.
Edelmann P, Gupta D: Hormonal investigations in adolescent idiopathic scoliosis. Acta Endocrinol (Kbh). 1974, 71-Suppl 184
328.
Kulis A, Zarzycki D, Jaśkiewicz J: Concentration of estradiol in girls with idiophatic scoliosis. Ortop Traumatol Rehabil. 2006, 8 (4): 455-9.PubMed
329.
Raczkowski JW: The concentrations of testosterone and estradiol in girls with adolescent idiopathic scoliosi. Neuroendocrinol Letters. 2007, 28 (3): 302-304.
330.
Burwell RG: Biology is the future of scoliosis treatment. Stud Health Technol Inform. 2002, 88: 309-15.PubMed
331.
Burwell RG, Dangerfield PH: The NOTOM hypothesis for idiopathic scoliosis: is it nullified by the delayed puberty of female rhythmic gymnasts and ballet dancers with scoliosis?. Stud Health Technol Inform. 2002, 91: 12-14.PubMed
332.
Burwell RG, Dangerfield PH: A possible neuroendocrine method for delaying the adolescent growth spurt and slowing scoliosis curve progression based on the NOTOM hypothesis. Potential of a medical treatment for progressive juvenile and adolescent idiopathic scoliosis. J Bone Joint Surg Br. 2003, 85-B (Supp III): 190-1.
333.
King AG: Modification of the spinal peak growth velocity as a possible treatment for adult scoliosis. Stud Health Technol Inform. 2002, 91: 489-491.PubMed
334.
Warren MP, Brooks-Gunn J, Hamilton LH, Warren LF, Hamilton WG: Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea. N Engl J Med. 1986, 314 (21): 1348-53.PubMed
335.
Warren MP, Stiehl AL: Exercise and female adolescents: effects on the reproductive and skeletal systems. J Am Med Womens Assoc. 1999, 54 (3): 115-20.PubMed
336.
Roth JA, Kim BG, Lin WL, Cho MI: Melatonin promotes osteoblast differentiation and bone formation. J Biol Chem. 1999, 274 (31): 22041-7.PubMed
337.
Man GC, Yeung YH, Wang WJ, Lee KM, Ng BK, Hung WY, Qiu Y, Cheng JC: The effect of melatonin on proliferation and differentiation of osteoblasts in adolescent idiopathic scoliosis vs normal control (Abstract). Stud Health Technol Inform. 2008, 140: 373-
338.
Man CWG, Wang W, Yeung HYB, Ng KWB, Hung VWY, Lee KMS, Ng TB, Qiu Y, Cheng JCY: Abnormal responses to melatonin in osteoblasts cultured from adolescent idiopathic scoliosis (Abstract). Proceedings of Pediatric Orthopaedic Society of North America 25th Anniversary. 2009, Boston Marriott Copley Place, 212- Annual Meeting Boston, Massachusetts, April 30-May 2 2009
339.
Wang WJ, Yeung YH, Man CWG, Lee KM, Ng BKW, Qiu Y, Cheng JCY: Abnormal proliferative response of chondrocytes to melatonin in girls with adolescent idiopathic scoliosis. Stud Health Technol Inform. 2008, 140: 370-
340.
Sun G, Wang WJ, Hwang A, Cheng J, Qiu Y: Expression of melatonn receptor in chondrocyte of adolescent idiopathic scoliosis. Stud Health Technol Inform. 2008, 140: 347-
341.
Buommino E, Tufano MA, Balato N, Canozo N, Donnarumma M, Gallo L, Balato A, Ayala F: Osteopontin: a new emerging role in psoriasis. Arch Dermatol Res. 2009, 301 (6): 397-404.PubMed
342.
Taylor TFK, Melrose J: The role of the intervertebral disc in adolescent idiopathic scoliosis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 359-369.
343.
Roberts S, Caterson B, Urban JPG: Structure and composition of the cartilage end plate and intervertebral disc in scoliosis. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): 371-381.
344.
Akhtar S, Davies JR, Caterson B: Ultrastructural localization and distribution of proteoglycan in normal and scoliotic lumbar disc. Spine. 2005, 30 (11): 1303-9.PubMed
345.
Yu J, Fairbank JC, Roberts S, Urban JP: The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral disc. Spine. 2005, 30 (16): 1815-20.PubMed
346.
Bertram H, Steck E, Zimmerman G, Chen B, Carstens C, Nerlich A, Richter W: Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression. Biochem Biophys Res Commun. 2006, 342 (3): 963-72.PubMed
347.
Grivas TB, Vasiliadis E, Malakasis M, Mouzakis V, Segos D: Intervertebral disc biomechanics in the pathogenesis of idiopathic scoliosis. Stud Health Technol Inform. 2006, 123: 80-83.PubMed
348.
Crean JK, Roberts S, Jaffray DC, Eisenstein SM, Duance VC: Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis. Spine (Phila Pa 1976). 1997, 22 (24): 2877-84.
349.
Burke JG, G Watson RW, Conhyea D, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM: Human nucleus pulposis can respond to a pro-inflammatory stimulus. Spine (Phila Pa 1976). 2003, 28 (24): 2685-93.
350.
Roberts S, Evans H, Trivedi J, Menage J: Histology and pathology of the human intervertebral disc. J Bone Joint Surg Am. 2006, 88 (Suppl 2): 10-4.PubMed
351.
Aulisa L, Papaleo P, Pola E, Angelini F, Aulisa AG, Tamburrelli FC, Pola P, Logroscino CA: Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study. Spine (Phila Pa 1976). 2007, 32 (24): 2700-2.
352.
Sverrisdóttir YB, Elam M, Herlitz H, Bengtsson BA, Johannsson G: Intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. J Clin Endocrinol Metab. 1998, 83 (6): 1881-5.PubMed
353.
Sverrisdóttir YB, Elam M, Caidahl K, Söderling AS, Herlitz H, Johannsson G: The effect of growth hormone (GH) replacement therapy on sympathetic nerve hyperactivity in hypopituitary adults: a double-blind, placebo-controlled, crossover, short-term trial followed by long-term open GH replacement in hypopituitary adults. J Hypertens. 2003, 21 (10): 1905-14.PubMed
354.
McMurray RG, Hackney AC: Interactions of metabolic hormones, adipose tissue and exercise. Sports Med. 2005, 35 (5): 393-412.PubMed
355.
Resmini E, Casu M, Patrone V, Murialdo G, Bianchi F, Giusti M, Ferone D, Minuto F: Sympathovagal imbalance in acromegalic patients. J Clin Endocrinol Metab. 2006, 91 (1): 115-20.PubMed
356.
Andersson IJ, Barlind A, Nyström HC, Olsson B, Skøtt O, Mobini R, Johansson M, Bergström G: Reduced sympathetic responsiveness as well as plasma and tissue noradrenaline concentration in growth hormone transgenic mice. Acta Physiol Scand. 2004, 182 (4): 369-78.PubMed
357.
Scott EM, Greenwood JP, Stoker JB, Mary DA, Gilbey SG: Sympathetic nerve hyperactivity is associated with increased peripheral vascular resistance in hypopituitary patients with growth hormone deficiency. Clin Endocrinol (Oxf). 2002, 56 (6): 759-63.
358.
Capaldo B, Lembo G, Rendina V, Vigorito C, Guida R, Cuocolo A, Fazio S, Saccà L: Sympathetic deactivation by growth hormone treatment in patients with dilated cardiomyopathy. Eur Heart J. 1998, 19 (4): 623-7.PubMed
359.
Ljung T, Holm G, Friberg P, Andersson B, Bengtsson BA, Svensson J, Dallman M, McEwen B, Björntorp P: The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men. Obes Res. 2000, 8 (7): 487-95.PubMed
360.
Sverrisdóttir YB, Johannsson G, Jungersten L, Wallin BG, Elam M: Is the somatotropic axis related to sympathetic nerve activity in healthy ageing men?. J Hypertens. 2001, 19 (11): 2019-24.PubMed
361.
Møller N, Jørgensen JO: Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009, 30 (2): 152-77.PubMed
362.
Weltman A, Pritzlaff CJ, Wideman L, Weltman JY, Blumer JL, Abbott RD, Hartman ML, Veldhuis JD: Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow. J Appl Physiol. 2000, 89 (2): 629-35.PubMed
363.
Bartness TJ, Song CK: Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue. J Lipid Res. 2007, 48 (8): 1655-72.PubMed
364.
Asher MA: Foreword. Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, State of the Art Reviews: Spine. Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. 2000, Philadelphia, Hanley & Belfus Inc, 14 (2): xiv-xv.
365.
Wever DJ, Tønseth KA, Veldhuizen AG, Cool JC, van Horn JR: Curve progression and spinal growth in brace treated idiopathic scoliosis. Clin Orthop Relat Res. 2000, 377: 169-79.PubMed
366.
Sarwark J, Aubin CE: Growth considerations of the immature spine. J Bone Joint Surg Am. 2007, 89 (Suppl 1): 8-13.PubMed
367.
Milenkovic SM, Kocijancic RI, Belojevic GA: Left handedness and spine deformities in early adolescence. Eur J Epidemiol. 2004, 19 (10): 969-72.PubMed
368.
Goldberg CJ, Moore DP, Fogarty EE, Dowling FE: Handedness and spinal deformity. Stud Health Technol Inform. 2006, 123: 442-8.PubMed
369.
Grivas TB, Vasiliadis ES, Polyzois VD, Mouzakis V: Trunk asymmetry and handedness in 8245 school children. Pediatr Rehabil. 2006, 9 (3): 259-66.PubMed
370.
Kouwenhoven JWM, Vincken KL, Bartels LW, Castelein RM: Analysis of pre-existent vertebral rotation in the normal spine. Spine. 2006, 31 (13): 1467-72.PubMed
371.
Burwell RG, Dangerfield PH, Freeman BJ, Aujla RK, Cole AA, Kirby AS, Pratt RK, Webb JK, Moulton A: Etiologic theories of idiopathic scoliosis: the breaking of bilateral symmetry in relation to left-right asymmetry of internal organs, right thoracic adolescent idiopathic scoliosis (AIS) and vertebrate evolution. Stud Health Technol Inform. 2006, 23: 1385-90.
372.
Davids JR, Chamberlin E, Blackhurst DW: Indications for magnetic resonance imaging in presumed adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2004, 86: 2187-95.PubMed
373.
Brockmeyer D, Gollogly S, Smith JT: Scoliosis associated with Chiari I malformations: the effect of suboccipital decompression on scoliosis curve progression. A preliminary study. Spine. 2003, 28 (22): 2505-9.PubMed
374.
Ugrinow VL, Bastrom T, Varley ES, Yaszay B, Newton PO: Left thoracic curves are not a mirror image of right thoracic idiopathic curves. Scoliosis Research Society 44th Annual Meeting and Course, San Antonio, Texas, USA, September 23-26. 2009, 61-
375.
Paus T: Mapping brain maturation and cognitive development during adolescence. Trends Cogn Sci. 2005, 9 (2): 60-8.PubMed
376.
Dangerfield PH, Taylor CJ: Anthropometric standards for term neonates. Early Hum Dev. 1983, 8 (3-4): 225-33.PubMed
377.
Dangerfield PH, Taylor CJ: Liverpool growth study: Neonatal anthropometric standards. Human growth and development. Edited by: Borms J, Hauspie R, Sand A, Suzanne C, Hebbelinck M. 1984, London: Plenum Press, 131-137.
378.
Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, Hebebrand J, Kiess W: Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab. 2002, 87 (10): 4587-94.PubMed
379.
Li HJ, Ji CY, Wang W, Hu YH: A twin study for serum leptin, soluble leptin receptor, and free insulin-like growth factor-I in pubertal females. J Clin Endocrinol Metab. 2005, 90 (6): 3659-64.PubMed
380.
Shapiro IM, Srinivas V: Metabolic consideration of epiphyseal growth: survival responses in a taxing environment. Bone. 2007, 40 (3): 561-7.PubMed
381.
Ahmed ML, Ong KK, Morrell DJ, Cox L, Drayer N, Perry L, Preece MA, Dunger DB: Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab. 1999, 84 (3): 899-905.PubMed
382.
Lin J, Barb CR, Matteri RL, Kraeling RR, Chen X, Meinersmann RJ, Rampacek GB: Long form leptin receptor mRNA expression in the brain, pituitary, and other tissues in the pig. Domest Anim Endocrinol. 2000, 19 (1): 53-61.PubMed
383.
Serrat MA, Lovejoy CO, King D: Age- and site-specific decline in insulin-like growth factor-I receptor expression is correlated with differential growth plate activity in the mouse hindlimb. Anat Rec (Hoboken). 2007, 290 (4): 375-81.
384.
Zhao CQ, Liu D, Li H, Jiang LS, Dai LY: Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Spine. 2008, 33 (23): E858-64.PubMed
385.
Brown MF, Hukkanen MV, McCarthy ID, Redfern DR, Batten JJ, Crock HV, Hughes SP, Polak JM: Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Joint Surg Br. 1997, 79 (1): 147-53.PubMed
386.
Syme C, Abrahamowicz M, Leonard GT, Perron M, Pitiot A, Qiu X, Richer L, Totman J, Veillette S, Xiao Y, Gaudet D, Paus T, Pausova Z: Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms. Arch Pediatr Adolesc Med. 2008, 162 (5): 453-61.PubMed
387.
Korr IM, Wright HM, Chace JA: Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculoskeletal system. Acta Neuroveg. Wien. 1964, 25: 589-606.PubMed
388.
Friedman JM: Causes and control of excess body fat. Nature. 2009, 459: 340-2.PubMed
389.
Cannon B, Nedergaard J: Brown adipose tissue: function and physiological significance. Physiol Rev. 2004, 84 (1): 277-359.PubMed
390.
Nedergaard J, Bengtsson T, Cannon B: Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007, 293 (2): E444-52.PubMed
391.
392.
van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ: Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009, 360 (15): 1500-8.PubMed
393.
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR: Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009, 360 (15): 1509-17.PubMedPubMedCentral
394.
Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P: Functional brown adipose tissue in healthy adults. N Engl J Med. 2009, 360 (15): 1518-25.PubMed
395.
Whelan J: The fat that makes you thin. New Sci. 2009, 203 (2721): 39-41.
396.
Heaney RP, Davies KM, Barger-Lux MJ: Calcium and weight: clinical studies. J Am Coll Nutr. 2002, 21 (2): 152S-155S.PubMed
397.
Zivicnjak M, Smolej Narancić N, Szirovicza L, Franke D, Hrenović J, Bisof V, Tomas Z, Skarić-Jurić T: Gender-specific growth patterns of transversal body dimensions in Croatian children and youth (2 to 18 years of age). Coll Antropol. 2008, 32 (2): 419-31.PubMed
398.
Mehta MH: The rib-vertebra angle in the early diagnosis between resolving and progressive infantile scoliosis. J Bone Joint Surg Br. 1972, 54 (2): 230-43.PubMed
399.
Kristmundsdottir F, Burwell RG, James JI: The rib-vertebra angles on the convexity and concavity of the spinal curve in infantile idiopathic scoliosis. Clin Orthop Relat Res. 1985, 201: 205-9.PubMed
400.
Grivas TB, Burwell RG, Vasiliadis ES, Webb JK: A segmental radiological study of the spine and rib--cage in children with progressive infantile idiopathic scoliosis. Scoliosis. 2006, 1: 17-PubMedPubMedCentral
401.
Burwell RG, Dangerfield PH, Vernon CL: Anthropometry and scoliosis. Scoliosis, Proceedings of a Fifth Symposium. Edited by: Zorab PA. 1977, London: Academic Press, 123-163.
402.
Dangerfield PH, Burwell RG, Vernon CL: Anthropometry and scoliosis. Spinal Deformities. Edited by: Roaf R. 1980, Tunbridge Wells, Kent, UK, Chapter 14: 259-28. Second
403.
Wynne-Davies R: Causative factors, particularly in the first six months of life. J Bone Joint Surg Br. 1975, 57 (2): 138-41.PubMed
404.
McMaster MJ: Infantile idiopathic scoliosis: can it be prevented?. J Bone Joint Surg Br. 1983, 65 (5): 612-7.PubMed
405.
406.
Frühbeck G, Becerril S, Sáinz N, Garrastachu P, García-Velloso MJ: BAT: a new target for human obesity?. Trends Pharmacol Sci. 2009, 30 (8): 387-96.PubMed
407.
Mehta MH: The natural history of infantile idiopathic scoliosis. Scoliosis, Proceedings of a Fifth Symposium. Edited by: Zorab PA. 1977, London: Academic Press, 103-122.
408.
Kirkwood TB: A systematic look at an old problem. Nature. 2008, 451 (7179): 644-7.PubMed
Metadata
Title
Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy
Authors
R Geoffrey Burwell
Ranjit K Aujla
Michael P Grevitt
Peter H Dangerfield
Alan Moulton
Tabitha L Randell
Susan I Anderson
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Scoliosis and Spinal Disorders / Issue 1/2009
Electronic ISSN: 2397-1789
DOI
https://doi.org/10.1186/1748-7161-4-24

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