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Published in: Implementation Science 1/2011

Open Access 01-12-2011 | Research

Task shifting and integration of HIV care into primary care in South Africa: The development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention

Authors: Kerry E Uebel, Lara R Fairall, Dingie HCJ van Rensburg, Willie F Mollentze, Max O Bachmann, Simon Lewin, Merrick Zwarenstein, Christopher J Colvin, Daniella Georgeu, Pat Mayers, Gill M Faris, Carl Lombard, Eric D Bateman

Published in: Implementation Science | Issue 1/2011

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Abstract

Background

Task shifting and the integration of human immunodeficiency virus (HIV) care into primary care services have been identified as possible strategies for improving access to antiretroviral treatment (ART). This paper describes the development and content of an intervention involving these two strategies, as part of the Streamlining Tasks and Roles to Expand Treatment and Care for HIV (STRETCH) pragmatic randomised controlled trial.

Methods: Developing the intervention

The intervention was developed following discussions with senior management, clinicians, and clinic staff. These discussions revealed that the establishment of separate antiretroviral treatment services for HIV had resulted in problems in accessing care due to the large number of patients at ART clinics. The intervention developed therefore combined the shifting from doctors to nurses of prescriptions of antiretrovirals (ARVs) for uncomplicated patients and the stepwise integration of HIV care into primary care services.

Results: Components of the intervention

The intervention consisted of regulatory changes, training, and guidelines to support nurse ART prescription, local management teams, an implementation toolkit, and a flexible, phased introduction. Nurse supervisors were equipped to train intervention clinic nurses in ART prescription using outreach education and an integrated primary care guideline. Management teams were set up and a STRETCH coordinator was appointed to oversee the implementation process.

Discussion

Three important processes were used in developing and implementing this intervention: active participation of clinic staff and local and provincial management, educational outreach to train nurses in intervention sites, and an external facilitator to support all stages of the intervention rollout.
The STRETCH trial is registered with Current Control Trials ISRCTN46836853.
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Literature
2.
go back to reference World Health Organization: Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector. Progress report 2009. 2009, Geneva: WHO Press World Health Organization: Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector. Progress report 2009. 2009, Geneva: WHO Press
3.
go back to reference Adam M, Johnson L: Estimation of adult antiretroviral coverage in South Africa. SAMJ. 2009, 99: 661-667.PubMed Adam M, Johnson L: Estimation of adult antiretroviral coverage in South Africa. SAMJ. 2009, 99: 661-667.PubMed
4.
go back to reference Department of Health: Operational Plan for Comprehensive HIV and AIDS Care, Management and Treatment for South Africa 2003. 2003, Pretoria: South African Department of Health Department of Health: Operational Plan for Comprehensive HIV and AIDS Care, Management and Treatment for South Africa 2003. 2003, Pretoria: South African Department of Health
5.
go back to reference Van Rensburg D: The Free State's approach to implementing the comprehensive plan: notes by a participant outsider. Acta Academica Supplementum 2006. 2006, Bloemfontein: UFS-SASOL library, 1: 44-93. Van Rensburg D: The Free State's approach to implementing the comprehensive plan: notes by a participant outsider. Acta Academica Supplementum 2006. 2006, Bloemfontein: UFS-SASOL library, 1: 44-93.
6.
go back to reference Victora C, Hanson K, Bryce J, Vaughan J: Achieving universal coverage with health interventions. Lancet. 2004, 364: 1541-1548.CrossRefPubMed Victora C, Hanson K, Bryce J, Vaughan J: Achieving universal coverage with health interventions. Lancet. 2004, 364: 1541-1548.CrossRefPubMed
7.
go back to reference Atun RA, Bennett S, Duran A: When do vertical (stand alone) programmes have a place in health systems?. 2008, Denmark: World Health Organization Atun RA, Bennett S, Duran A: When do vertical (stand alone) programmes have a place in health systems?. 2008, Denmark: World Health Organization
8.
go back to reference McCoy D, Chopra M, Loewenson R, Aitken J, Ngulube T, Muula A, Ray S, Kureyi T, Ijumba P, Rowson M: Expanding access to antiretroviral therapy in Sub-Saharan Africa: avoiding the pitfalls and dangers, capitalizing on the opportunities. American Journal of Public Health. 2005, 95: 18-22.CrossRefPubMedPubMedCentral McCoy D, Chopra M, Loewenson R, Aitken J, Ngulube T, Muula A, Ray S, Kureyi T, Ijumba P, Rowson M: Expanding access to antiretroviral therapy in Sub-Saharan Africa: avoiding the pitfalls and dangers, capitalizing on the opportunities. American Journal of Public Health. 2005, 95: 18-22.CrossRefPubMedPubMedCentral
9.
go back to reference Schneider H, Blaauw D, Gilson L, Chabiguli N, Goudge J: Health systems and access to antiretroviral drugs for HIV in Southern Africa: service delivery and human resource challenges. Reproductive Health Matters. 2006, 14: 12-23.CrossRefPubMed Schneider H, Blaauw D, Gilson L, Chabiguli N, Goudge J: Health systems and access to antiretroviral drugs for HIV in Southern Africa: service delivery and human resource challenges. Reproductive Health Matters. 2006, 14: 12-23.CrossRefPubMed
10.
go back to reference El Sadr WM, Abrams EJ: Scale up of HIV care and treatment: can it transform health care services in resource-limited settings?. AIDS. 2007, 21: S65-S70.CrossRefPubMed El Sadr WM, Abrams EJ: Scale up of HIV care and treatment: can it transform health care services in resource-limited settings?. AIDS. 2007, 21: S65-S70.CrossRefPubMed
11.
go back to reference Ooms G, Van Damme W, Baker B, Zeitz P, Schrecker T: The diagonal approach to Global Fund financing: a cure for the broader malaise of health systems?. Globalisation and Health. 2008, 4: 6-CrossRef Ooms G, Van Damme W, Baker B, Zeitz P, Schrecker T: The diagonal approach to Global Fund financing: a cure for the broader malaise of health systems?. Globalisation and Health. 2008, 4: 6-CrossRef
12.
go back to reference Variava E: Profile: HIV in North West Province South Africa. Southern African Journal of HIV Medicine. 2006, 23: 35-37. Variava E: Profile: HIV in North West Province South Africa. Southern African Journal of HIV Medicine. 2006, 23: 35-37.
14.
go back to reference World Health Organization: Antiretroviral therapy in primary health care: experience of the Chiradzulu programme in Malawi. Case study. MSF Malawi, and the Ministry of Health and Population, Chiradzulu district Malawi. 2004, Geneva: WHO Press World Health Organization: Antiretroviral therapy in primary health care: experience of the Chiradzulu programme in Malawi. Case study. MSF Malawi, and the Ministry of Health and Population, Chiradzulu district Malawi. 2004, Geneva: WHO Press
15.
go back to reference Jaffar S, Amuron B, Foster S, Birungi J, Levin J, Namara G, Nabiryo C, Ndembi N, Kyomuhangi K, Opio A: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial. Lancet. 2009, 374: 2080-2089.CrossRefPubMedPubMedCentral Jaffar S, Amuron B, Foster S, Birungi J, Levin J, Namara G, Nabiryo C, Ndembi N, Kyomuhangi K, Opio A: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial. Lancet. 2009, 374: 2080-2089.CrossRefPubMedPubMedCentral
16.
go back to reference Cohen R, Lynch S, Bygrave H, Eggers E, Vlahakis N, Hilderbrand K, Knight L, Pillay P, Saranchuk P, Goemaere E: Antiretroviral treatment outcomes from a nurse-driven community supported HIV/AIDS treatment programme in rural Lesotho: observational cohort assessment at two years. Journal of the International AIDS Society. 2009, 12: 23-CrossRefPubMedPubMedCentral Cohen R, Lynch S, Bygrave H, Eggers E, Vlahakis N, Hilderbrand K, Knight L, Pillay P, Saranchuk P, Goemaere E: Antiretroviral treatment outcomes from a nurse-driven community supported HIV/AIDS treatment programme in rural Lesotho: observational cohort assessment at two years. Journal of the International AIDS Society. 2009, 12: 23-CrossRefPubMedPubMedCentral
17.
go back to reference Gaede B: Rural ARV Provision: policy implications for accelerated ARV rollout. Reflections on a national dialogue on rural ARV programmes. Southern African Journal of HIV Medicine. 2006, 23-25. December Gaede B: Rural ARV Provision: policy implications for accelerated ARV rollout. Reflections on a national dialogue on rural ARV programmes. Southern African Journal of HIV Medicine. 2006, 23-25. December
18.
go back to reference Fredlund V, Nash J: How far should they walk? Antiretroviral therapy access in a rural community in northern KwaZulu-Natal, South Africa. JID. 2007, 196 (Suppl 3): S469-S473.CrossRefPubMed Fredlund V, Nash J: How far should they walk? Antiretroviral therapy access in a rural community in northern KwaZulu-Natal, South Africa. JID. 2007, 196 (Suppl 3): S469-S473.CrossRefPubMed
20.
go back to reference Hirschborn L, Ojikutu B, Rodriguez W: Research for change: using implementation research to strengthen HIV care and treatment scale-up in resource limited settings. JID. 2007, 196 (Suppl 3): S516-522.CrossRef Hirschborn L, Ojikutu B, Rodriguez W: Research for change: using implementation research to strengthen HIV care and treatment scale-up in resource limited settings. JID. 2007, 196 (Suppl 3): S516-522.CrossRef
21.
go back to reference Campbell N, Murray E, Darbyshire J, Emery J, Farmer A, Griffiths F, Guthrie B, Lester H, Wilson P, Kinmoth A: Designing and evaluating complex interventions to improve health care. BMJ. 2007, 334: 455-459.CrossRefPubMedPubMedCentral Campbell N, Murray E, Darbyshire J, Emery J, Farmer A, Griffiths F, Guthrie B, Lester H, Wilson P, Kinmoth A: Designing and evaluating complex interventions to improve health care. BMJ. 2007, 334: 455-459.CrossRefPubMedPubMedCentral
22.
go back to reference Michie S, Fixsen D, Grimshaw J, Eccles M: Specifying and reporting complex behaviour change interventions: the need for a scientific method. Implementation Science. 2009, 4: 40-CrossRefPubMedPubMedCentral Michie S, Fixsen D, Grimshaw J, Eccles M: Specifying and reporting complex behaviour change interventions: the need for a scientific method. Implementation Science. 2009, 4: 40-CrossRefPubMedPubMedCentral
23.
go back to reference Glasziou P, Chalmers I, Altman D, Bastian H, Boutron I, Brice A, Jamtvedt G, Farmer A, Ghersi D, Groves T: Taking health care interventions from trial to practice. BMJ. 2010, 341: c3852-CrossRefPubMed Glasziou P, Chalmers I, Altman D, Bastian H, Boutron I, Brice A, Jamtvedt G, Farmer A, Ghersi D, Groves T: Taking health care interventions from trial to practice. BMJ. 2010, 341: c3852-CrossRefPubMed
25.
go back to reference Bheekie A, Buskens I, Allen S, English R, Mayers P, Fairall L, Majara B, Bateman E, Zwarenstein M, Bachman M: The practical approach to lung health in South Africa (PALSA) intervention:respiratory guideline implementation for nurse trainers. International Nursing Review. 2006, 53: 261-268.CrossRefPubMed Bheekie A, Buskens I, Allen S, English R, Mayers P, Fairall L, Majara B, Bateman E, Zwarenstein M, Bachman M: The practical approach to lung health in South Africa (PALSA) intervention:respiratory guideline implementation for nurse trainers. International Nursing Review. 2006, 53: 261-268.CrossRefPubMed
26.
go back to reference Fairall L, Zwarenstein M, Bateman E, Bachman M, Lombard C, Majara B, Joubert G, English R, Bheekie A, van Rensburg D: Effect of educational outreach to nurses on tuberculosis case detection and primary care of respiratory illness: pragmatic cluster randomized controlled trial. BMJ. 2005, 331: 750-754.CrossRefPubMedPubMedCentral Fairall L, Zwarenstein M, Bateman E, Bachman M, Lombard C, Majara B, Joubert G, English R, Bheekie A, van Rensburg D: Effect of educational outreach to nurses on tuberculosis case detection and primary care of respiratory illness: pragmatic cluster randomized controlled trial. BMJ. 2005, 331: 750-754.CrossRefPubMedPubMedCentral
27.
go back to reference Zwarenstein M, Fairall L, Lombard C, Mayers P, Bheekie A, English R, Lewin S, Bachmann M, Bateman E: Outreach education integrates HIV/AIDS/ART and Tuberculosis care in South African primary care clinics: a pragmatic randomised trial. BMJ. 2011, 342: d2022-CrossRefPubMedPubMedCentral Zwarenstein M, Fairall L, Lombard C, Mayers P, Bheekie A, English R, Lewin S, Bachmann M, Bateman E: Outreach education integrates HIV/AIDS/ART and Tuberculosis care in South African primary care clinics: a pragmatic randomised trial. BMJ. 2011, 342: d2022-CrossRefPubMedPubMedCentral
28.
go back to reference Fairall L, Bachmann M, Zwarenstein M, Lombard C, Uebel K, Van Vuuren C, Steyn D, Boulle A, Bateman E: Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol. Trials. 2008, 9: 21-26.CrossRefPubMedPubMedCentral Fairall L, Bachmann M, Zwarenstein M, Lombard C, Uebel K, Van Vuuren C, Steyn D, Boulle A, Bateman E: Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol. Trials. 2008, 9: 21-26.CrossRefPubMedPubMedCentral
30.
go back to reference Shisana O, Rehle T, Simbayi L, Zuma K, Jooste S, Pillay-van-Wyk V, Mbele N, Van Zyl J, Parker W, Zungu P: South African national HIV prevalence, incidence, behaviour and communication survey 2008: a turning point among teenagers?. 2009, Cape Town: HSRC Press Shisana O, Rehle T, Simbayi L, Zuma K, Jooste S, Pillay-van-Wyk V, Mbele N, Van Zyl J, Parker W, Zungu P: South African national HIV prevalence, incidence, behaviour and communication survey 2008: a turning point among teenagers?. 2009, Cape Town: HSRC Press
31.
go back to reference Fairall L, Bachmann M, Louwagie G, van Vuuren C, Chikobvu P, Steyn D, Staniland G, Timmerman V, Msimanga M, Seebregts C: Effectiveness of antiretroviral treatment in a South African program: a cohort study. Arch Int Med. 2008, 168: 86-93.CrossRef Fairall L, Bachmann M, Louwagie G, van Vuuren C, Chikobvu P, Steyn D, Staniland G, Timmerman V, Msimanga M, Seebregts C: Effectiveness of antiretroviral treatment in a South African program: a cohort study. Arch Int Med. 2008, 168: 86-93.CrossRef
32.
go back to reference Wouters E, Heunis C, Van Rensburg D, Meulemans H: Physical and emotional health outcomes after 12 months of public sector ART in the Free State province of South African: a longitudinal study using structural equation modelling. BMC Public Health. 2009, 9: 103-CrossRefPubMedPubMedCentral Wouters E, Heunis C, Van Rensburg D, Meulemans H: Physical and emotional health outcomes after 12 months of public sector ART in the Free State province of South African: a longitudinal study using structural equation modelling. BMC Public Health. 2009, 9: 103-CrossRefPubMedPubMedCentral
33.
go back to reference Janse van Rensburg-Bonthuyzen E, Engelbrecht M, Steyn F, Jacobs N, HH S, Van Rensburg D: Resources and infrastructure for the delivery of antiretroviral therapy at primary health care facilities in the Free State province, South Africa. SAHARA J. 2008, 5: 106-112.CrossRefPubMed Janse van Rensburg-Bonthuyzen E, Engelbrecht M, Steyn F, Jacobs N, HH S, Van Rensburg D: Resources and infrastructure for the delivery of antiretroviral therapy at primary health care facilities in the Free State province, South Africa. SAHARA J. 2008, 5: 106-112.CrossRefPubMed
34.
go back to reference Van Rensburg H, Steyn F, Schneider H, Loffstadt L: Human resource development and antiretroviral treatment in Free State province South Africa. Human Resources for Health. 2008, 6: 15-CrossRefPubMedPubMedCentral Van Rensburg H, Steyn F, Schneider H, Loffstadt L: Human resource development and antiretroviral treatment in Free State province South Africa. Human Resources for Health. 2008, 6: 15-CrossRefPubMedPubMedCentral
35.
go back to reference Engelbrecht M, Bester C, Van den Berg H, Van Rensburg H: A study of predictors and levels of burnout: the case of professional nurses in primary health care facilities in the Free State. South African Journal of Economics. 2008, 76: S15-S27.CrossRef Engelbrecht M, Bester C, Van den Berg H, Van Rensburg H: A study of predictors and levels of burnout: the case of professional nurses in primary health care facilities in the Free State. South African Journal of Economics. 2008, 76: S15-S27.CrossRef
36.
go back to reference Uebel K, Timmermans V, Ingle S, Van Rensburg D, Mollentze W: Towards universal ARV access: achievements and challenges in the Free State, South Africa: a retrospective study. SAMJ. 2010, 100: 589-593.CrossRefPubMed Uebel K, Timmermans V, Ingle S, Van Rensburg D, Mollentze W: Towards universal ARV access: achievements and challenges in the Free State, South Africa: a retrospective study. SAMJ. 2010, 100: 589-593.CrossRefPubMed
37.
go back to reference Colvin C, Fairall L, Lewin S, Goergeu D, Zwarenstein M, Bachmann M, Uebel K, Bachman M: Expanding access to ART in South Africa: The role of nurse-initiated treatment. SAMJ. 2010, 100: 210-212.CrossRefPubMed Colvin C, Fairall L, Lewin S, Goergeu D, Zwarenstein M, Bachmann M, Uebel K, Bachman M: Expanding access to ART in South Africa: The role of nurse-initiated treatment. SAMJ. 2010, 100: 210-212.CrossRefPubMed
38.
go back to reference English R, Bateman E, Zwarenstein M, Fairall L, Bheekie A, Bachman M, Majara B, Ottmani S, Scherpbier R: Development of a South African integrated syndromic respiratory disease guideline for primary care. Primary Care Respiratory Journal. 2008, 17: 156-163.CrossRefPubMed English R, Bateman E, Zwarenstein M, Fairall L, Bheekie A, Bachman M, Majara B, Ottmani S, Scherpbier R: Development of a South African integrated syndromic respiratory disease guideline for primary care. Primary Care Respiratory Journal. 2008, 17: 156-163.CrossRefPubMed
39.
go back to reference Stein J, Lewin S, Fairall L, Mayers P, English R, Bheekie A, Bateman E, Zwarenstein M: Building capacity for antiretroviral delivery in South Africa: A qualitative evaluation of the PALSA PLUS nurse training programme. BMC Health Services Research. 2008, 8: 240-CrossRefPubMedPubMedCentral Stein J, Lewin S, Fairall L, Mayers P, English R, Bheekie A, Bateman E, Zwarenstein M: Building capacity for antiretroviral delivery in South Africa: A qualitative evaluation of the PALSA PLUS nurse training programme. BMC Health Services Research. 2008, 8: 240-CrossRefPubMedPubMedCentral
40.
go back to reference The Medicine and Related Substances Act (Act 101 of 1965) Section 22(A) (5) (f). The Medicine and Related Substances Act (Act 101 of 1965) Section 22(A) (5) (f).
41.
go back to reference The Nursing Act (Act 33 of 2005) Section 56. The Nursing Act (Act 33 of 2005) Section 56.
42.
go back to reference World Health Organization: Chronic HIV care with ARV therapy and prevention: Integrated Management of Adolescent and Adult Illnesses. 2007, Geneva: WHO Press World Health Organization: Chronic HIV care with ARV therapy and prevention: Integrated Management of Adolescent and Adult Illnesses. 2007, Geneva: WHO Press
43.
go back to reference Leykum L, Pugh J, Lanham H, Harmon J, McDaniel R: Implementing research design: integrating participatory action research into randomised controlled trials. Implementation Science. 2009, 4: 69-CrossRefPubMedPubMedCentral Leykum L, Pugh J, Lanham H, Harmon J, McDaniel R: Implementing research design: integrating participatory action research into randomised controlled trials. Implementation Science. 2009, 4: 69-CrossRefPubMedPubMedCentral
44.
go back to reference Baker R, Camosso-Stefinovic J, Gillies C, Shaw E, Cheater F, Flottorp S, Robertson N: Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database of Systematic Reviews. 2010, Art. No.:CD005470-3 Baker R, Camosso-Stefinovic J, Gillies C, Shaw E, Cheater F, Flottorp S, Robertson N: Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database of Systematic Reviews. 2010, Art. No.:CD005470-3
45.
go back to reference McIntyre D, Klugman B: The human face of decentralization and integration of health services: experience from South Africa. Reproductive Health Matters. 2003, 11: 108-119.CrossRefPubMed McIntyre D, Klugman B: The human face of decentralization and integration of health services: experience from South Africa. Reproductive Health Matters. 2003, 11: 108-119.CrossRefPubMed
46.
go back to reference O'Brien M, Rogers S, Jamtvedt G, Oxman A, Odgaard-Jensen J, Kristofferson D, Forsetlund L, Bainbridge D, Freemantle N, Davis D: Educational outreach visits: effects on professional practice and health care outcomes (Review). Cochrane Database of Systematic Reviews. 2008, 4: Art.Nr.: CD000409- O'Brien M, Rogers S, Jamtvedt G, Oxman A, Odgaard-Jensen J, Kristofferson D, Forsetlund L, Bainbridge D, Freemantle N, Davis D: Educational outreach visits: effects on professional practice and health care outcomes (Review). Cochrane Database of Systematic Reviews. 2008, 4: Art.Nr.: CD000409-
47.
go back to reference Stetler C, Legro M, Rycroft-Malone J, Bowman C, Curran G, Guihan M, Hagedorn H, Pineros S, Wallace C: Role of external facilitation in implementation of research findings: a qualitative evaluation of facilitation experiences in the Veterans Health Administration. Implementation Science. 2006, 1: 23-CrossRefPubMedPubMedCentral Stetler C, Legro M, Rycroft-Malone J, Bowman C, Curran G, Guihan M, Hagedorn H, Pineros S, Wallace C: Role of external facilitation in implementation of research findings: a qualitative evaluation of facilitation experiences in the Veterans Health Administration. Implementation Science. 2006, 1: 23-CrossRefPubMedPubMedCentral
48.
go back to reference Harvey G, Loftus Hills A, Rycroft-Malone J, Titchen A, Kitson A, McCormack B, Seers K: Getting evidence into practice: the role and function of facilitation. Journal of Advanced Nursing. 2002, 37: 577-588.CrossRefPubMed Harvey G, Loftus Hills A, Rycroft-Malone J, Titchen A, Kitson A, McCormack B, Seers K: Getting evidence into practice: the role and function of facilitation. Journal of Advanced Nursing. 2002, 37: 577-588.CrossRefPubMed
49.
go back to reference Oakley A, Strange V, Bonell C, Allen E, Stephenson J, RIPPLE study team: Process evaluation in randomized controlled trials of complex interventions. BMJ. 2006, 332: 413-416.CrossRefPubMedPubMedCentral Oakley A, Strange V, Bonell C, Allen E, Stephenson J, RIPPLE study team: Process evaluation in randomized controlled trials of complex interventions. BMJ. 2006, 332: 413-416.CrossRefPubMedPubMedCentral
Metadata
Title
Task shifting and integration of HIV care into primary care in South Africa: The development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention
Authors
Kerry E Uebel
Lara R Fairall
Dingie HCJ van Rensburg
Willie F Mollentze
Max O Bachmann
Simon Lewin
Merrick Zwarenstein
Christopher J Colvin
Daniella Georgeu
Pat Mayers
Gill M Faris
Carl Lombard
Eric D Bateman
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Implementation Science / Issue 1/2011
Electronic ISSN: 1748-5908
DOI
https://doi.org/10.1186/1748-5908-6-86

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