Skip to main content
Top
Published in: Substance Abuse Treatment, Prevention, and Policy 1/2008

Open Access 01-12-2008 | Research

Experience of road and other trauma by the opiate dependent patient: a survey report

Author: Albert S Reece

Published in: Substance Abuse Treatment, Prevention, and Policy | Issue 1/2008

Login to get access

Abstract

Background

Trauma plays an important role in the experience of many patients with substance use disorder, but is relatively under-studied particularly in Australia. The present survey examined the lifetime prevalence of various forms of trauma including driving careers in the context of relevant medical conditions.

Methods

A survey was undertaken in a family medicine practice with a special interest in addiction medicine in Brisbane, Australia.

Results

Of 350 patients surveyed, 220 were substance dependent, and 130 were general medical patients. Addicted patients were younger (mean ± S.D. 33.72 ± 8.14 vs. 44.24 ± 16.91 years, P < 0.0001) and had shorter driving histories (15.96 ± 8.50 vs. 25.54 ± 15.03 years, P < 0.0001). They had less driving related medical problems (vision, spectacle use, diabetes) but more fractures, surgical operations, dental trauma and assaults. Addicted patients also had significantly worse driving histories on most parameters measured including percent with driving suspensions (O.R. = 7.70, C.I. 4.38–13.63), duration of suspensions (1.71 ± 3.60 vs. 0.11 ± 0.31 years, P < 0.0001), number of motor vehicle collisions (2.00 ± 3.30 vs. 1.10 ± 1.32, P = 0.01), numbers of cars repaired (1.73 ± 3.59 vs. 1.08 ± 1.60, P = 0.042), rear end collisions (O.R. = 1.90, CI 1.13–3.25), running away after car crashes (O.R. = 26.37, CI 4.31–1077.48), other people hospitalized (O.R. = 2.00, C.I. 0.93–4.37, P = 0.037) and people killed (17 vs. 0 P = 0.0005). Upon multivariate analysis group membership was shown to be a significant determinant of both cars repaired and cars hit when controlled for length of driving history. Hence use of all types of drugs (O.R. = 10.07, C.I. 8.80–14.72) was more common in addicted patients as were general (O.R. = 3.64, C.I. 2.99–4.80) and road (O.R.= 2.73, C.I. 2.36–3.15) trauma.

Conclusion

This study shows that despite shorter driving histories, addicted patients have worse driving careers and general trauma experience than the comparison group which is not explained by associated medical conditions. Trauma is relevant to addiction management at both the patient and policy levels. Substance dependence policies which focus largely on prevention of virus transmission likely have too narrow a public health focus, and tend to engender an unrealistically simplistic and trivialized view of the addiction syndrome. Reduction of drug driving and drug related trauma likely require policies which reduce drug use per se, and are not limited to harm reduction measures alone.
Appendix
Available only for authorised users
Literature
1.
go back to reference Hall W, Homel R: [Commentary] Reducing cannabis-impaired driving: is there sufficient evidence for drug testing of drivers?. Addiction. 2007, 102 (12): 1918-1919. 10.1111/j.1360-0443.2007.02042.x.CrossRefPubMed Hall W, Homel R: [Commentary] Reducing cannabis-impaired driving: is there sufficient evidence for drug testing of drivers?. Addiction. 2007, 102 (12): 1918-1919. 10.1111/j.1360-0443.2007.02042.x.CrossRefPubMed
4.
go back to reference Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR, Sacco RL, Papapanou PN: Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation. 2005, 111: 576-582. 10.1161/01.CIR.0000154582.37101.15.PubMedCentralCrossRefPubMed Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR, Sacco RL, Papapanou PN: Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation. 2005, 111: 576-582. 10.1161/01.CIR.0000154582.37101.15.PubMedCentralCrossRefPubMed
5.
go back to reference Beck JD, Eke P, Heiss G, Madianos P, Couper D, Lin D, Moss K, Elter J, Offenbacher S: Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation. 2005, 112: 19-24. 10.1161/CIRCULATIONAHA.104.511998.CrossRefPubMed Beck JD, Eke P, Heiss G, Madianos P, Couper D, Lin D, Moss K, Elter J, Offenbacher S: Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation. 2005, 112: 19-24. 10.1161/CIRCULATIONAHA.104.511998.CrossRefPubMed
6.
go back to reference Reece AS: Dentition of addiction in Queensland: poor dental status and major contributing drugs. Aust Dent J. 2007, 52: 144-149. 10.1111/j.1834-7819.2007.tb00480.x.CrossRefPubMed Reece AS: Dentition of addiction in Queensland: poor dental status and major contributing drugs. Aust Dent J. 2007, 52: 144-149. 10.1111/j.1834-7819.2007.tb00480.x.CrossRefPubMed
7.
go back to reference Kelly E, Darke S, Ross J: A review of drug use and driving: epidemiology, impairment, risk factors and risk perceptions. Drug Alcohol Rev. 2004, 23: 319-344. 10.1080/09595230412331289482.CrossRefPubMed Kelly E, Darke S, Ross J: A review of drug use and driving: epidemiology, impairment, risk factors and risk perceptions. Drug Alcohol Rev. 2004, 23: 319-344. 10.1080/09595230412331289482.CrossRefPubMed
8.
go back to reference Holmgren A, Holmgren P, Kugelberg FC, Jones AW, Ahlner J: Predominance of illicit drugs and poly-drug use among drug-impaired drivers in sweden. Traffic Inj Prev. 2007, 8: 361-367. 10.1080/15389580701329344.CrossRefPubMed Holmgren A, Holmgren P, Kugelberg FC, Jones AW, Ahlner J: Predominance of illicit drugs and poly-drug use among drug-impaired drivers in sweden. Traffic Inj Prev. 2007, 8: 361-367. 10.1080/15389580701329344.CrossRefPubMed
9.
go back to reference Alvarez FJ, Fierro I, Del Rio MC: Cannabis and driving: results from a general population survey. Forensic Sci Int. 2007, 170: 111-116. 10.1016/j.forsciint.2007.03.024.CrossRefPubMed Alvarez FJ, Fierro I, Del Rio MC: Cannabis and driving: results from a general population survey. Forensic Sci Int. 2007, 170: 111-116. 10.1016/j.forsciint.2007.03.024.CrossRefPubMed
10.
go back to reference Giovanardi D, Castellana CN, Pisa S, Poppi B, Pinetti D, Bertolini A, Ferrari A: Prevalence of abuse of alcohol and other drugs among injured drivers presenting to the emergency department of the University Hospital of Modena, Italy. Drug Alcohol Depend. 2005, 80: 135-138. 10.1016/j.drugalcdep.2005.04.010.CrossRefPubMed Giovanardi D, Castellana CN, Pisa S, Poppi B, Pinetti D, Bertolini A, Ferrari A: Prevalence of abuse of alcohol and other drugs among injured drivers presenting to the emergency department of the University Hospital of Modena, Italy. Drug Alcohol Depend. 2005, 80: 135-138. 10.1016/j.drugalcdep.2005.04.010.CrossRefPubMed
11.
go back to reference Ramaekers JG, Moeller MR, van Ruitenbeek P, Theunissen EL, Schneider E, Kauert G: Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairment. Drug Alcohol Depend. 2006, 85: 114-122. 10.1016/j.drugalcdep.2006.03.015.CrossRefPubMed Ramaekers JG, Moeller MR, van Ruitenbeek P, Theunissen EL, Schneider E, Kauert G: Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairment. Drug Alcohol Depend. 2006, 85: 114-122. 10.1016/j.drugalcdep.2006.03.015.CrossRefPubMed
12.
go back to reference Laumon B, Gadegbeku B, Martin JL, Biecheler MB: Cannabis intoxication and fatal road crashes in France: population based case-control study. Bmj. 2005, 331: 1371-10.1136/bmj.38648.617986.1F.PubMedCentralCrossRefPubMed Laumon B, Gadegbeku B, Martin JL, Biecheler MB: Cannabis intoxication and fatal road crashes in France: population based case-control study. Bmj. 2005, 331: 1371-10.1136/bmj.38648.617986.1F.PubMedCentralCrossRefPubMed
13.
go back to reference Giroud C, Augsburger M, Favrat B, Menetrey A, Pin MA, Rothuizen LE, Appenzeller M, Buclin T, Mathieu S, Castella V: [Effects of oral cannabis and dronabinol on driving capacity]. Ann Pharm Fr. 2006, 64: 161-172.CrossRefPubMed Giroud C, Augsburger M, Favrat B, Menetrey A, Pin MA, Rothuizen LE, Appenzeller M, Buclin T, Mathieu S, Castella V: [Effects of oral cannabis and dronabinol on driving capacity]. Ann Pharm Fr. 2006, 64: 161-172.CrossRefPubMed
14.
go back to reference Mura P, Kintz P, Ludes B, Gaulier JM, Marquet P, Martin-Dupont S, Vincent F, Kaddour A, Goulle JP, Nouveau J: Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Sci Int. 2003, 133: 79-85. 10.1016/S0379-0738(03)00052-5.CrossRefPubMed Mura P, Kintz P, Ludes B, Gaulier JM, Marquet P, Martin-Dupont S, Vincent F, Kaddour A, Goulle JP, Nouveau J: Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Sci Int. 2003, 133: 79-85. 10.1016/S0379-0738(03)00052-5.CrossRefPubMed
15.
go back to reference Lowenstein SR, Koziol-McLain J: Drugs and traffic crash responsibility: a study of injured motorists in Colorado. J Trauma. 2001, 50: 313-320.CrossRefPubMed Lowenstein SR, Koziol-McLain J: Drugs and traffic crash responsibility: a study of injured motorists in Colorado. J Trauma. 2001, 50: 313-320.CrossRefPubMed
16.
go back to reference Michael Walsh J, Flegel R, Atkins R, Cangianelli LA, Cooper C, Welsh C, Kerns TJ: Drug and alcohol use among drivers admitted to a Level-1 trauma center. Accid Anal Prev. 2005, 37: 894-901. 10.1016/j.aap.2005.04.013.CrossRefPubMed Michael Walsh J, Flegel R, Atkins R, Cangianelli LA, Cooper C, Welsh C, Kerns TJ: Drug and alcohol use among drivers admitted to a Level-1 trauma center. Accid Anal Prev. 2005, 37: 894-901. 10.1016/j.aap.2005.04.013.CrossRefPubMed
17.
go back to reference McCarthy DM, Lynch AM, Pederson SL: Driving after use of alcohol and marijuana in college students. Psychol Addict Behav. 2007, 21: 425-430. 10.1037/0893-164X.21.3.425.CrossRefPubMed McCarthy DM, Lynch AM, Pederson SL: Driving after use of alcohol and marijuana in college students. Psychol Addict Behav. 2007, 21: 425-430. 10.1037/0893-164X.21.3.425.CrossRefPubMed
18.
go back to reference Ch'ng CW, Fitzgerald M, Gerostamoulos J, Cameron P, Bui D, Drummer OH, Potter J, Odell M: Drug use in motor vehicle drivers presenting to an Australian, adult major trauma centre. Emerg Med Australas. 2007, 19: 359-365. 10.1111/j.1742-6723.2007.00958.x.CrossRefPubMed Ch'ng CW, Fitzgerald M, Gerostamoulos J, Cameron P, Bui D, Drummer OH, Potter J, Odell M: Drug use in motor vehicle drivers presenting to an Australian, adult major trauma centre. Emerg Med Australas. 2007, 19: 359-365. 10.1111/j.1742-6723.2007.00958.x.CrossRefPubMed
19.
go back to reference Grotenhermen F, Leson G, Berghaus G, Drummer OH, Kruger HP, Longo M, Moskowitz H, Perrine B, Ramaekers JG, Smiley A, Tunbridge R: Developing limits for driving under cannabis. Addiction. 2007, 102: 1910-1917. 10.1111/j.1360-0443.2007.02009.x.CrossRefPubMed Grotenhermen F, Leson G, Berghaus G, Drummer OH, Kruger HP, Longo M, Moskowitz H, Perrine B, Ramaekers JG, Smiley A, Tunbridge R: Developing limits for driving under cannabis. Addiction. 2007, 102: 1910-1917. 10.1111/j.1360-0443.2007.02009.x.CrossRefPubMed
20.
go back to reference Drummer OH, Gerostamoulos D, Chu M, Swann P, Boorman M, Cairns I: Drugs in oral fluid in randomly selected drivers. Forensic Sci Int. 2007, 170: 105-110. 10.1016/j.forsciint.2007.03.028.CrossRefPubMed Drummer OH, Gerostamoulos D, Chu M, Swann P, Boorman M, Cairns I: Drugs in oral fluid in randomly selected drivers. Forensic Sci Int. 2007, 170: 105-110. 10.1016/j.forsciint.2007.03.028.CrossRefPubMed
21.
go back to reference Darke S, Kelly E, Ross J: Drug driving among injecting drug users in Sydney, Australia: prevalence, risk factors and risk perceptions. Addiction. 2004, 99: 175-185. 10.1046/j.1360-0443.2003.00604.x.CrossRefPubMed Darke S, Kelly E, Ross J: Drug driving among injecting drug users in Sydney, Australia: prevalence, risk factors and risk perceptions. Addiction. 2004, 99: 175-185. 10.1046/j.1360-0443.2003.00604.x.CrossRefPubMed
22.
go back to reference Mann RE, Smart RG, Stoduto G, Adlaf EM, Ialomiteanu A: Alcohol consumption and problems among road rage victims and perpetrators. J Stud Alcohol. 2004, 65: 161-168.CrossRefPubMed Mann RE, Smart RG, Stoduto G, Adlaf EM, Ialomiteanu A: Alcohol consumption and problems among road rage victims and perpetrators. J Stud Alcohol. 2004, 65: 161-168.CrossRefPubMed
23.
go back to reference Galanti MR, Wickholm S, Gilljam H: Between harm and dangers. Oral snuff use, cigarette smoking and problem behaviours in a survey of Swedish male adolescents. Eur J Public Health. 2001, 11: 340-345. 10.1093/eurpub/11.3.340.CrossRefPubMed Galanti MR, Wickholm S, Gilljam H: Between harm and dangers. Oral snuff use, cigarette smoking and problem behaviours in a survey of Swedish male adolescents. Eur J Public Health. 2001, 11: 340-345. 10.1093/eurpub/11.3.340.CrossRefPubMed
24.
go back to reference Butters JE, Smart RG, Mann RE, Asbridge M: Illicit drug use, alcohol use and problem drinking among infrequent and frequent road ragers. Drug Alcohol Depend. 2005, 80: 169-175. 10.1016/j.drugalcdep.2005.03.018.CrossRefPubMed Butters JE, Smart RG, Mann RE, Asbridge M: Illicit drug use, alcohol use and problem drinking among infrequent and frequent road ragers. Drug Alcohol Depend. 2005, 80: 169-175. 10.1016/j.drugalcdep.2005.03.018.CrossRefPubMed
25.
go back to reference Albery IP, Strang J, Gossop M, Griffiths P: Illicit drugs and driving: prevalence, beliefs and accident involvement among a cohort of current out-of-treatment drug users. Drug Alcohol Depend. 2000, 58: 197-204. 10.1016/S0376-8716(99)00101-5.CrossRefPubMed Albery IP, Strang J, Gossop M, Griffiths P: Illicit drugs and driving: prevalence, beliefs and accident involvement among a cohort of current out-of-treatment drug users. Drug Alcohol Depend. 2000, 58: 197-204. 10.1016/S0376-8716(99)00101-5.CrossRefPubMed
26.
go back to reference Jones CG, Swift W, Donnelly NJ, Weatherburn DJ: Correlates of driving under the influence of cannabis. Drug Alcohol Depend. 2007, 88: 83-86. 10.1016/j.drugalcdep.2006.09.005.CrossRefPubMed Jones CG, Swift W, Donnelly NJ, Weatherburn DJ: Correlates of driving under the influence of cannabis. Drug Alcohol Depend. 2007, 88: 83-86. 10.1016/j.drugalcdep.2006.09.005.CrossRefPubMed
27.
go back to reference Darke S, Ross J, Williamson A, Mills KL, Havard A, Teesson M: Patterns and correlates of attempted suicide by heroin users over a 3-year period: findings from the Australian treatment outcome study. Drug Alcohol Depend. 2007, 87: 146-152. 10.1016/j.drugalcdep.2006.08.010.CrossRefPubMed Darke S, Ross J, Williamson A, Mills KL, Havard A, Teesson M: Patterns and correlates of attempted suicide by heroin users over a 3-year period: findings from the Australian treatment outcome study. Drug Alcohol Depend. 2007, 87: 146-152. 10.1016/j.drugalcdep.2006.08.010.CrossRefPubMed
28.
go back to reference Baewert A, Gombas W, Schindler SD, Peternell-Moelzer A, Eder H, Jagsch R, Fischer G: Influence of peak and trough levels of opioid maintenance therapy on driving aptitude. Eur Addict Res. 2007, 13: 127-135. 10.1159/000101548.CrossRefPubMed Baewert A, Gombas W, Schindler SD, Peternell-Moelzer A, Eder H, Jagsch R, Fischer G: Influence of peak and trough levels of opioid maintenance therapy on driving aptitude. Eur Addict Res. 2007, 13: 127-135. 10.1159/000101548.CrossRefPubMed
29.
go back to reference Maddux JF, Williams TR, Ziegler JA: Driving records before and during methadone maintenance. Am J Drug Alcohol Abuse. 1977, 4: 91-100. 10.3109/00952997709002750.CrossRefPubMed Maddux JF, Williams TR, Ziegler JA: Driving records before and during methadone maintenance. Am J Drug Alcohol Abuse. 1977, 4: 91-100. 10.3109/00952997709002750.CrossRefPubMed
30.
go back to reference Engeland A, Skurtveit S, Morland J: Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. Ann Epidemiol. 2007, 17: 597-602. 10.1016/j.annepidem.2007.03.009.CrossRefPubMed Engeland A, Skurtveit S, Morland J: Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. Ann Epidemiol. 2007, 17: 597-602. 10.1016/j.annepidem.2007.03.009.CrossRefPubMed
31.
go back to reference Wilson D: Experience with drugs and driving in Queensland, Australia. Med Sci Law. 1985, 25: 2-10.PubMed Wilson D: Experience with drugs and driving in Queensland, Australia. Med Sci Law. 1985, 25: 2-10.PubMed
32.
go back to reference Speedy T, Baldwin D, Jowett G, Gallina M, Jehanli A: Development and validation of the Cozart DDS oral fluid collection device. Forensic Sci Int. 2007, 170: 117-120. 10.1016/j.forsciint.2007.03.038.CrossRefPubMed Speedy T, Baldwin D, Jowett G, Gallina M, Jehanli A: Development and validation of the Cozart DDS oral fluid collection device. Forensic Sci Int. 2007, 170: 117-120. 10.1016/j.forsciint.2007.03.038.CrossRefPubMed
33.
go back to reference Davey J, Leal N, Freeman J: Screening for drugs in oral fluid: illicit drug use and drug driving in a sample of Queensland motorists. Drug Alcohol Rev. 2007, 26: 301-307. 10.1080/09595230701247764.CrossRefPubMed Davey J, Leal N, Freeman J: Screening for drugs in oral fluid: illicit drug use and drug driving in a sample of Queensland motorists. Drug Alcohol Rev. 2007, 26: 301-307. 10.1080/09595230701247764.CrossRefPubMed
34.
go back to reference Crouch DJ, Walsh JM, Flegel R, Cangianelli L, Baudys J, Atkins R: An evaluation of selected oral fluid point-of-collection drug-testing devices. J Anal Toxicol. 2005, 29: 244-248.CrossRefPubMed Crouch DJ, Walsh JM, Flegel R, Cangianelli L, Baudys J, Atkins R: An evaluation of selected oral fluid point-of-collection drug-testing devices. J Anal Toxicol. 2005, 29: 244-248.CrossRefPubMed
35.
go back to reference Cone EJ, Clarke J, Tsanaclis L: Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid. J Anal Toxicol. 2007, 31: 424-433.CrossRefPubMed Cone EJ, Clarke J, Tsanaclis L: Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid. J Anal Toxicol. 2007, 31: 424-433.CrossRefPubMed
36.
go back to reference Wodak A, Saunders B: Harm reduction means what I choose it to mean. Drug Alcohol Rev. 1995, 14: 269-271. 10.1080/09595239500185341.CrossRefPubMed Wodak A, Saunders B: Harm reduction means what I choose it to mean. Drug Alcohol Rev. 1995, 14: 269-271. 10.1080/09595239500185341.CrossRefPubMed
37.
go back to reference UNAIDS: At risk and neglected: Four key populations. In: 2006 Report on the global AIDS epidemic. 2007, UNAIDS: UNAIDS, 1: 104-122. UNAIDS: At risk and neglected: Four key populations. In: 2006 Report on the global AIDS epidemic. 2007, UNAIDS: UNAIDS, 1: 104-122.
38.
go back to reference Digiusto E, Shakeshaft A, Ritter A, O'Brien S, Mattick RP: Serious adverse events in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). Addiction. 2004, 99: 450-460. 10.1111/j.1360-0443.2004.00654.x.CrossRefPubMed Digiusto E, Shakeshaft A, Ritter A, O'Brien S, Mattick RP: Serious adverse events in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). Addiction. 2004, 99: 450-460. 10.1111/j.1360-0443.2004.00654.x.CrossRefPubMed
39.
go back to reference Soyka M, Hock B, Kagerer S, Lehnert R, Limmer C, Kuefner H: Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial. J Clin Psychopharmacol. 2005, 25: 490-493. 10.1097/01.jcp.0000178417.60426.60.CrossRefPubMed Soyka M, Hock B, Kagerer S, Lehnert R, Limmer C, Kuefner H: Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial. J Clin Psychopharmacol. 2005, 25: 490-493. 10.1097/01.jcp.0000178417.60426.60.CrossRefPubMed
40.
go back to reference Schindler SD, Ortner R, Peternell A, Eder H, Opgenoorth E, Fischer G: Maintenance therapy with synthetic opioids and driving aptitude. Eur Addict Res. 2004, 10: 80-87. 10.1159/000076118.CrossRefPubMed Schindler SD, Ortner R, Peternell A, Eder H, Opgenoorth E, Fischer G: Maintenance therapy with synthetic opioids and driving aptitude. Eur Addict Res. 2004, 10: 80-87. 10.1159/000076118.CrossRefPubMed
41.
go back to reference Rapeli P, Fabritius C, Alho H, Salaspuro M, Wahlbeck K, Kalska H: Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. BMC Clin Pharmacol. 2007, 7: 5-10.1186/1472-6904-7-5.PubMedCentralCrossRefPubMed Rapeli P, Fabritius C, Alho H, Salaspuro M, Wahlbeck K, Kalska H: Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. BMC Clin Pharmacol. 2007, 7: 5-10.1186/1472-6904-7-5.PubMedCentralCrossRefPubMed
42.
go back to reference Darke S, Hall W, Kaye S, Ross J, Duflou J: Hair morphine concentrations of fatal heroin overdose cases and living heroin users. Addiction. 2002, 97: 977-984. 10.1046/j.1360-0443.2002.00148.x.CrossRefPubMed Darke S, Hall W, Kaye S, Ross J, Duflou J: Hair morphine concentrations of fatal heroin overdose cases and living heroin users. Addiction. 2002, 97: 977-984. 10.1046/j.1360-0443.2002.00148.x.CrossRefPubMed
44.
go back to reference Yamashita T, Ninomiya M, Hernandez Acosta P, Garcia-Verdugo JM, Sunabori T, Sakaguchi M, Adachi K, Kojima T, Hirota Y, Kawase T: Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci. 2006, 26: 6627-6636. 10.1523/JNEUROSCI.0149-06.2006.CrossRefPubMed Yamashita T, Ninomiya M, Hernandez Acosta P, Garcia-Verdugo JM, Sunabori T, Sakaguchi M, Adachi K, Kojima T, Hirota Y, Kawase T: Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci. 2006, 26: 6627-6636. 10.1523/JNEUROSCI.0149-06.2006.CrossRefPubMed
45.
go back to reference Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O: Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med. 2002, 8: 963-970. 10.1038/nm747.CrossRefPubMed Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O: Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med. 2002, 8: 963-970. 10.1038/nm747.CrossRefPubMed
46.
go back to reference Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH: Quantitative morphology of the caudate and putamen in patients with cocaine dependence. Am J Psychiatry. 2001, 158: 486-489. 10.1176/appi.ajp.158.3.486.CrossRefPubMed Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH: Quantitative morphology of the caudate and putamen in patients with cocaine dependence. Am J Psychiatry. 2001, 158: 486-489. 10.1176/appi.ajp.158.3.486.CrossRefPubMed
47.
go back to reference Chang L, Alicata D, Ernst T, Volkow N: Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction. 2007, 102 (Suppl 1): 16-32. 10.1111/j.1360-0443.2006.01782.x.CrossRefPubMed Chang L, Alicata D, Ernst T, Volkow N: Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction. 2007, 102 (Suppl 1): 16-32. 10.1111/j.1360-0443.2006.01782.x.CrossRefPubMed
48.
go back to reference Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T: Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry. 2005, 57: 967-974. 10.1016/j.biopsych.2005.01.039.CrossRefPubMed Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T: Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry. 2005, 57: 967-974. 10.1016/j.biopsych.2005.01.039.CrossRefPubMed
49.
go back to reference Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA: An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA. 2007, 104: 5638-5643. 10.1073/pnas.0611721104.PubMedCentralCrossRefPubMed Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA: An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA. 2007, 104: 5638-5643. 10.1073/pnas.0611721104.PubMedCentralCrossRefPubMed
50.
go back to reference Driscoll I, Howard SR, Stone JC, Monfils MH, Tomanek B, Brooks WM, Sutherland RJ: The aging hippocampus: a multi-level analysis in the rat. Neuroscience. 2006, 139: 1173-1185. 10.1016/j.neuroscience.2006.01.040.CrossRefPubMed Driscoll I, Howard SR, Stone JC, Monfils MH, Tomanek B, Brooks WM, Sutherland RJ: The aging hippocampus: a multi-level analysis in the rat. Neuroscience. 2006, 139: 1173-1185. 10.1016/j.neuroscience.2006.01.040.CrossRefPubMed
51.
go back to reference Darke S, Kaye S, Duflou J: Systemic disease among cases of fatal opioid toxicity. Addiction. 2006, 101: 1299-1305. 10.1111/j.1360-0443.2006.01495.x.CrossRefPubMed Darke S, Kaye S, Duflou J: Systemic disease among cases of fatal opioid toxicity. Addiction. 2006, 101: 1299-1305. 10.1111/j.1360-0443.2006.01495.x.CrossRefPubMed
52.
go back to reference Reece AS: Evidence of Accelerated Ageing in Clinical Drug Addiction from Immune, Hepatic and Metabolic Biomarkers. Immun Ageing. 2007, 4: 6-10.1186/1742-4933-4-6.PubMedCentralCrossRefPubMed Reece AS: Evidence of Accelerated Ageing in Clinical Drug Addiction from Immune, Hepatic and Metabolic Biomarkers. Immun Ageing. 2007, 4: 6-10.1186/1742-4933-4-6.PubMedCentralCrossRefPubMed
53.
go back to reference Kim TW, Alford DP, Malabanan A, Holick MF, Samet JH: Low bone density in patients receiving methadone maintenance treatment. Drug Alcohol Depend. 2006, 85: 258-262. 10.1016/j.drugalcdep.2006.05.027.CrossRefPubMed Kim TW, Alford DP, Malabanan A, Holick MF, Samet JH: Low bone density in patients receiving methadone maintenance treatment. Drug Alcohol Depend. 2006, 85: 258-262. 10.1016/j.drugalcdep.2006.05.027.CrossRefPubMed
54.
go back to reference Reece AS: Hair graying in substance addiction. Arch Dermatol. 2007, 143: 116-118. 10.1001/archderm.143.1.116.CrossRefPubMed Reece AS: Hair graying in substance addiction. Arch Dermatol. 2007, 143: 116-118. 10.1001/archderm.143.1.116.CrossRefPubMed
55.
go back to reference Reece AS, Davidson P: Deficit of circulating stem – progenitor cells in opiate addiction: a pilot study. Subst Abuse Treat Prev Policy. 2007, 2: 19-10.1186/1747-597X-2-19.PubMedCentralCrossRefPubMed Reece AS, Davidson P: Deficit of circulating stem – progenitor cells in opiate addiction: a pilot study. Subst Abuse Treat Prev Policy. 2007, 2: 19-10.1186/1747-597X-2-19.PubMedCentralCrossRefPubMed
56.
go back to reference Pillai R, Nair BS, Watson RR: AIDS, drugs of abuse and the immune system: a complex immunotoxicological network. Arch Toxicol. 1991, 65: 609-617. 10.1007/BF02098025.CrossRefPubMed Pillai R, Nair BS, Watson RR: AIDS, drugs of abuse and the immune system: a complex immunotoxicological network. Arch Toxicol. 1991, 65: 609-617. 10.1007/BF02098025.CrossRefPubMed
57.
go back to reference Cabral GA: Drugs of abuse, immune modulation, and AIDS. J Neuroimmune Pharmacol. 2006, 1: 280-295. 10.1007/s11481-006-9023-5.CrossRefPubMed Cabral GA: Drugs of abuse, immune modulation, and AIDS. J Neuroimmune Pharmacol. 2006, 1: 280-295. 10.1007/s11481-006-9023-5.CrossRefPubMed
58.
go back to reference Haffajee AD, Bogren A, Hasturk H, Feres M, Lopez NJ, Socransky SS: Subgingival microbiota of chronic periodontitis subjects from different geographic locations. J Clin Periodontol. 2004, 31: 996-1002. 10.1111/j.1600-051X.2004.00597.x.CrossRefPubMed Haffajee AD, Bogren A, Hasturk H, Feres M, Lopez NJ, Socransky SS: Subgingival microbiota of chronic periodontitis subjects from different geographic locations. J Clin Periodontol. 2004, 31: 996-1002. 10.1111/j.1600-051X.2004.00597.x.CrossRefPubMed
59.
go back to reference Newman MGTHH, Carranza FA: Carranza's Clinical Periodontology. 2002, London: W.B. Saunders & Co Newman MGTHH, Carranza FA: Carranza's Clinical Periodontology. 2002, London: W.B. Saunders & Co
60.
go back to reference Cheze M, Deveaux M, Martin C, Lhermitte M, Pepin G: Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake. Forensic Sci Int. 2007, 170: 100-104. 10.1016/j.forsciint.2007.02.033.CrossRefPubMed Cheze M, Deveaux M, Martin C, Lhermitte M, Pepin G: Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake. Forensic Sci Int. 2007, 170: 100-104. 10.1016/j.forsciint.2007.02.033.CrossRefPubMed
61.
go back to reference Tsanaclis L, Wicks JF: Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample. Forensic Sci Int. 2007, 170 (2-3): 121-128. 10.1016/j.forsciint.2007.03.033.CrossRefPubMed Tsanaclis L, Wicks JF: Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample. Forensic Sci Int. 2007, 170 (2-3): 121-128. 10.1016/j.forsciint.2007.03.033.CrossRefPubMed
Metadata
Title
Experience of road and other trauma by the opiate dependent patient: a survey report
Author
Albert S Reece
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Substance Abuse Treatment, Prevention, and Policy / Issue 1/2008
Electronic ISSN: 1747-597X
DOI
https://doi.org/10.1186/1747-597X-3-10

Other articles of this Issue 1/2008

Substance Abuse Treatment, Prevention, and Policy 1/2008 Go to the issue