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Head & Face Medicine
Published in: Head & Face Medicine 1/2012

Open Access 01-12-2012 | Research

Magnetic resonance imaging, computed tomography, and 68Ga-DOTATOC positron emission tomography for imaging skull base meningiomas with infracranial extension treated with stereotactic radiotherapy - a case series

Authors: Reinhold Graf, Michail Plotkin, Ingo G Steffen, Reinhard Wurm, Peter Wust, Winfried Brenner, Volker Budach, Harun Badakhshi

Published in: Head & Face Medicine | Issue 1/2012

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Abstract

Introduction

Magnetic resonance imaging (MRI) and computed tomography (CT) with 68Ga-DOTATOC positron emission tomography (68Ga-DOTATOC-PET) were compared retrospectively for their ability to delineate infracranial extension of skull base (SB) meningiomas treated with fractionated stereotactic radiotherapy.

Methods

Fifty patients with 56 meningiomas of the SB underwent MRI, CT, and 68Ga-DOTATOC PET/CT prior to fractionated stereotactic radiotherapy. The study group consisted of 16 patients who had infracranial meningioma extension, visible on MRI ± CT (MRI/CT) or PET, and were evaluated further. The respective findings were reviewed independently, analyzed with respect to correlations, and compared with each other.

Results

Within the study group, SB transgression was associated with bony changes visible by CT in 14 patients (81%). Tumorous changes of the foramen ovale and rotundum were evident in 13 and 8 cases, respectively, which were accompanied by skeletal muscular invasion in 8 lesions. We analysed six designated anatomical sites of the SB in each of the 16 patients. Of the 96 sites, 42 had infiltration that was delineable by MRI/CT and PET in 35 cases and by PET only in 7 cases. The mean infracranial volume that was delineable in PET was 10.1 ± 10.6 cm3, which was somewhat larger than the volume detectable in MRI/CT (8.4 ± 7.9 cm3).

Conclusions

68Ga-DOTATOC-PET allows detection and assessment of the extent of infracranial meningioma invasion. This method seems to be useful for planning fractionated stereotactic radiation when used in addition to conventional imaging modalities that are often inconclusive in the SB region.
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Metadata
Title
Magnetic resonance imaging, computed tomography, and 68Ga-DOTATOC positron emission tomography for imaging skull base meningiomas with infracranial extension treated with stereotactic radiotherapy - a case series
Authors
Reinhold Graf
Michail Plotkin
Ingo G Steffen
Reinhard Wurm
Peter Wust
Winfried Brenner
Volker Budach
Harun Badakhshi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Head & Face Medicine / Issue 1/2012
Electronic ISSN: 1746-160X
DOI
https://doi.org/10.1186/1746-160X-8-1

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