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Head & Face Medicine
Published in: Head & Face Medicine 1/2007

Open Access 01-12-2007 | Research

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

Authors: Kivanc Akca, Ebru Sarac, Ugur Baysal, Mete Fanuscu, Ting-Ling Chang, Murat Cehreli

Published in: Head & Face Medicine | Issue 1/2007

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Abstract

Background

Osteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats.

Methods

Fifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed en bloc and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 μm wide peri-implant volume of interest (VOI).

Results

Mean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (P < .05). Differences in trabecular-thickness and -separation around implants in all groups were similar (P > .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (P < .05).

Conclusion

Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.
Appendix
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Metadata
Title
Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats
Authors
Kivanc Akca
Ebru Sarac
Ugur Baysal
Mete Fanuscu
Ting-Ling Chang
Murat Cehreli
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Head & Face Medicine / Issue 1/2007
Electronic ISSN: 1746-160X
DOI
https://doi.org/10.1186/1746-160X-3-28

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