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Diagnostic Pathology

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Open Access 01-12-2014 | Research

Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma

Authors: Xing Hua, Xiaoxiao Huang, Zexiao Liao, Qi Xian, Lina Yu

Published in: Diagnostic Pathology | Issue 1/2014

Abstract

Background

To investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV).

Methods

Clinicopathological data of 53 cases of REAH were retrospectively analyzed. The immunoreactivity for CK 7, CK20, CEA, p53, and Ki-67, Alcian blue–periodic acid-Schiff (AB-PAS) staining and in situ hybridization for EBV-encoded RNA (EBER) were carried out.

Results

REAH lesions were covered with ciliated columnar epithelium and proliferation of subepithelial glands, which were positive for CK7, and negative for CK20, CEA, and p53. Goblet cell metaplasia was stained blue by AB-PAS. The frequency of EBER positive cases in REAH located in nasopharynx was 27.78%, compared with that in the nasal cavity (15.79%) and paranasal sinuses (12.50%), there were no statistical differences.

Conclusions

REAH is an uncommon entity with distinctive morphologic features and EBV may have nothing to do with REAH.

Virtual slides

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http://www.diagnosticpathology.diagnomx.eu/vs/5875687401178748

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Title: Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma
Authors: Xing Hua
Xiaoxiao Huang
Zexiao Liao
Qi Xian
Lina Yu
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-9-70

ACC 2024 Congress

Springer Medicine

Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma

Abstract

Background

Methods

Results

Conclusions

Virtual slides

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Virtual slides

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