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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Case Report

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review

Authors: Ying Yang, Yanmei Wang, Jinsong He, Guoqing Pan, Xiaoyu Tuo, Aimei Jiang, Li Bian

Published in: Diagnostic Pathology | Issue 1/2014

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Abstract

Background

Malignant adenomyoepithelioma and adenoid cystic carcinoma are both rare malignant epithelial-myoepithelial tumors of the breast. We report a very rare case with a malignant adenomyoepithelioma combining with adenoid cystic carcinoma in a single mass.

Case presentation

A 61-year-old female presented with a palpable painless mass in the right breast. Mammography revealed a large irregular dense shadow without obvious internal calcification. A simple lumpectomy was performed, and a 1.6cm well-circumscribed pale-tan nodule was presented. Histologically, the nodule was composed of two obscure lobules. One exhibited typical histological image of adenoid cystic carcinoma, the other one showed the image of epithelial-myoepithelial carcinoma of salivary gland, and support the diagnosis of biphasic malignant adenomyoepithelioma. Transition between the two lobules was gradual. Immunohistochemically, CK18 and P63 highlighted the epithelial and myoepithelial cells respectively in both lesions. CD117 was positive in the epithelial cells of adenoid cystic carcinoma, but was totally negative in malignant adenomyoepithelioma.

Conclusion

This report is, to our knowledge, the first case that combines these two tumors in a single mass. In addition, we present a review of the literature. The histogenesis of these tumors is also discussed.
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Metadata
Title
Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review
Authors
Ying Yang
Yanmei Wang
Jinsong He
Guoqing Pan
Xiaoyu Tuo
Aimei Jiang
Li Bian
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-148

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