Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Review

XPC Lys939Gln polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis

Authors: Qiliu Peng, Xianjun Lao, Weizhong Tang, Zhiping Chen, Ruolin Li, Xue Qin, Shan Li

Published in: Diagnostic Pathology | Issue 1/2014

Login to get access

Abstract

Background

Published studies investigating the association between XPC Lys939Gln polymorphism and colorectal cancer (CRC) risk reported inconclusive results. We performed a meta-analysis to derive a precise estimation of the relationship.

Methods

A comprehensive literature search was done in databases PubMed, EMBASE, and Cochrane library up to December 2013. The association between XPC Lys939Gln polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).

Results

Eight studies with 3,301 cases and 4,177 controls were included in the meta-analysis. We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169–1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145–1.388, P = 0.000). In stratified analyses by ethnicity, smoking, and study quality, significant increased CRC risk was found in Asians (Gln/lys vs. Lys/Lys: OR = 1.345, 95% CI 1.187–1.523, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.317, 95% CI 1.170–1.484, P = 0.000), nonsmokers (Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.286, 95% CI 1.020–1.622, P = 0.033), and high quality studies. In subgroup analysis by source of control, significant increased CRC risk was found in both hospital-based studies and population-based studies. However, in subgroup analysis according to cancer location, no any significant association was detected.

Conclusions

This meta-analysis suggests that the XPC is a candidate gene for CRC susceptibility. The XPC Lys939Gln polymorphism may play an important role in CRC development among Asians and nonsmokers. Further large and well-designed studies are needed to confirm this association.

Virtual Slides

The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​1665902729125948​
Appendix
Available only for authorised users
Literature
1.
2.
Fan NJ, Kang R, Ge XY, Li M, Liu Y, Chen HM, Gao CF: Identification alpha-2-HS-glycoprotein precursor and tubulin beta chain as serology diagnosis biomarker of colorectal cancer. Diagn Pathol. 2014, 9: 53-PubMedPubMedCentralCrossRef
3.
Ferlay J, Parkin DM, Steliarova-Foucher E: Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer. 2010, 46: 765-781.PubMedCrossRef
4.
Sung JJ, Lau JY, Goh KL, Leung WK: Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 2005, 6: 871-876.PubMedCrossRef
5.
Liu Y, Tang W, Wang J, Xie L, Li T, He Y, Qin X, Li S: Clinicopathological and prognostic significance of S100A4 overexpression in colorectal cancer: a meta-analysis. Diagn Pathol. 2013, 8: 181-PubMedPubMedCentralCrossRef
6.
7.
Giovannucci E: An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001, 10: 725-731.PubMed
8.
Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L, Wolk A: Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst. 2001, 93: 525-533.PubMedCrossRef
9.
Qiu L, Wang Z, Shi X: Associations between XPC polymorphisms and risk of cancers: A meta-analysis. Eur J Cancer. 2008, 44: 2241-2253.PubMedCrossRef
10.
Thoma BS, Vasquez KM: Critical DNA damage recognition functions of XPC-hHR23B and XPA-RPA in nucleotide excision repair. Mol Carcinog. 2003, 38: 1-13.PubMedCrossRef
11.
Tapias A, Auriol J, Forget D, Enzlin JH, Scharer OD, Coin F, Coulombe B, Egly JM: Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors. J Biol Chem. 2004, 279: 19074-19083.PubMedPubMedCentralCrossRef
12.
Leibeling D, Laspe P, Emmert S: Nucleotide excision repair and cancer. J Mol Histol. 2006, 37: 225-238.PubMedCrossRef
13.
Khan SG, Muniz-Medina V, Shahlavi T, Baker CC, Inui H, Ueda T, Emmert S, Schneider TD, Kraemer KH: The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function. Nucleic Acids Res. 2002, 30: 3624-3631.PubMedPubMedCentralCrossRef
14.
Blankenburg S, Konig IR, Moessner R, Laspe P, Thoms KM, Krueger U, Khan SG, Westphal G, Berking C, Volkenandt M, Reich K, Neumann C, Ziegler A, Kraemer KH, Emmert S: Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study. Carcinogenesis. 2005, 26: 1085-1090.PubMedCrossRef
15.
Sanyal S, Festa F, Sakano S, Zhang Z, Steineck G, Norming U, Wijkstrom H, Larsson P, Kumar R, Hemminki K: Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis. 2004, 25: 729-734.PubMedCrossRef
16.
Zhang L, Zhang Z, Yan W: Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta. 2005, 359: 150-155.PubMedCrossRef
17.
Casas JP, Hingorani AD, Bautista LE, Sharma P: Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol. 2004, 61: 1652-1661.PubMedCrossRef
18.
Wangefjord S, Brandstedt J, Lindquist KE, Nodin B, Jirstrom K, Eberhard J: Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer. Diagn Pathol. 2013, 8: 10-PubMedPubMedCentralCrossRef
19.
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000, 283: 2008-2012.PubMedCrossRef
20.
Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, Thompson J, Hall I, Kaufman J, Leung TF, Helms PJ, Hakonarson H, Halpi E, Navon R, Attia J: Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol. 2005, 162: 201-211.PubMedCrossRef
21.
Lau J, Ioannidis JP, Schmid CH: Quantitative synthesis in systematic reviews. Ann Intern Med. 1997, 127: 820-826.PubMedCrossRef
22.
Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21: 1539-1558.PubMedCrossRef
23.
24.
Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959, 22: 719-748.PubMed
25.
26.
Duval S, Tweedie R: Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000, 56: 455-463.PubMedCrossRef
27.
Slyskova J, Naccarati A, Pardini B, Polakova V, Vodickova L, Smerhovsky Z, Levy M, Lipska L, Liska V, Vodicka P: Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls. Mutagenesis. 2012, 27: 225-232.PubMedCrossRef
28.
Berndt SI, Platz EA, Fallin MD, Thuita LW, Hoffman SC, Helzlsouer KJ: Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2006, 15: 2263-2269.PubMedCrossRef
29.
Pardini B, Naccarati A, Novotny J, Smerhovsky Z, Vodickova L, Polakova V, Hanova M, Slyskova J, Tulupova E, Kumar R, Bortlik M, Barale R, Hemminki K, Vodicka P: DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic. Mutat Res. 2008, 638: 146-153.PubMedCrossRef
30.
Gil J, Ramsey D, Stembalska A, Karpinski P, Pesz KA, Laczmanska I, Leszczynski P, Grzebieniak Z, Sasiadek MM: The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. Mol Biol Rep. 2012, 39: 527-534.PubMedCrossRef
31.
Yue AM, Xie ZB, Zhao HF, Guo SP, Shen YH, Wang HP: Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population. Asian Pac J Cancer Prev. 2013, 14: 3085-3091.PubMedCrossRef
32.
Ahmad Aizat AA, Siti Nurfatimah MS, Aminudin MM, Ankathil R: XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians. World J Gastroenterol. 2013, 19: 3623-3628.PubMedPubMedCentralCrossRef
33.
Engin AB, Karahalil B, Engin A, Karakaya AE: Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma. Genet Test Mol Biomarkers. 2010, 14: 559-564.PubMedCrossRef
34.
Wu Y, Jin M, Liu B, Liang X, Yu Y, Li Q, Ma X, Yao K, Chen K: The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population. Mol Carcinog. 2011, 50: 189-198.PubMedCrossRef
35.
Liu D, Wu HZ, Zhang YN, Kang H, Sun MJ, Wang EH, Yang XL, Lian MQ, Yu ZJ, Zhao L, Olopade OI, Wei MJ: DNA repair genes XPC, XPG polymorphisms: relation to the risk of colorectal carcinoma and therapeutic outcome with Oxaliplatin-based adjuvant chemotherapy. Mol Carcinog. 2012, 51 (Suppl 1): E83-E93.PubMedCrossRef
36.
Hansen RD, Sorensen M, Tjonneland A, Overvad K, Wallin H, Raaschou-Nielsen O, Vogel U: XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer. Mutat Res. 2007, 619: 68-80.PubMedCrossRef
37.
38.
39.
Garcia-Closas M, Malats N, Real FX, Welch R, Kogevinas M, Chatterjee N, Pfeiffer R, Silverman D, Dosemeci M, Tardon A, Serra C, Carrato A, Garcia-Closas R, Castano-Vinyals G, Chanock S, Yeager M, Rothman N: Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2006, 15: 536-542.PubMedCrossRef
40.
Cheng D, Shi H, Zhang K, Yi L, Zhen G: RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis. Diagn Pathol. 2014, 9: 18-PubMedPubMedCentralCrossRef
41.
42.
Sugasawa K, Ng JM, Masutani C, Iwai S, van der Spek PJ, Eker AP, Hanaoka F, Bootsma D, Hoeijmakers JH: Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell. 1998, 2: 223-232.PubMedCrossRef
43.
Goode EL, Ulrich CM, Potter JD: Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev. 2002, 11: 1513-1530.PubMed
44.
Wang L, Cai S, Teng Z, Zhao X, Chen X, Bai X: Insulin therapy contributes to the increased risk of colorectal cancer in diabetes patients: a meta-analysis. Diagn Pathol. 2013, 8: 180-PubMedPubMedCentralCrossRef
45.
Benhamou S, Sarasin A: ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review. Am J Epidemiol. 2005, 161: 1-14.PubMedCrossRef
46.
Metadata
Title
XPC Lys939Gln polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis
Authors
Qiliu Peng
Xianjun Lao
Weizhong Tang
Zhiping Chen
Ruolin Li
Xue Qin
Shan Li
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-120

Other articles of this Issue 1/2014

Diagnostic Pathology 1/2014 Go to the issue

Letter to the Editor

Intraductal fibroadenoma under the nipple in an 11-year-old female

Research

Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells

Research

Diagnosis of secondary amyloidosis in alkaptonuria

Research

Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis

Research

Silencing BMP-2 expression inhibits A549 and H460 cell proliferation and migration

Research

Follow-up of breast papillary lesion on core needle biopsy: experience in African-American population