Skip to main content
Top
Published in: Diagnostic Pathology 1/2013

Open Access 01-09-2013 | Proceedings

Impact of tumor heterogeneity on disease-free survival in a series of 368 patients treated for a breast cancer

Authors: Myriam Oger, Mohamed Allaoui, Nicolas Elie, Jacques Marnay, Paulette Herlin, Benoît Plancoulaine, Jacques Chasle, Véronique Becette, Catherine Bor-Angelier

Published in: Diagnostic Pathology | Special Issue 1/2013

Login to get access

Excerpt

Tumor heterogeneity [14] is an old concept but its impact on the cancerogenesis process is poorly understood. Breast cancer is a noteworthy model for its frequency, and for the diversity of its phenotypes and of its evolution. This study examines the influence of the heterogeneity of tumor proliferation on disease-free survival of patients with a breast carcinoma. …
Literature
1.
go back to reference Dodd LG, Kerns B-J, Dodge RK, Layfield LJ: Intratumoral Heterogeneity in Primary Breast Carcinoma: Study of Concurrent Parameters. Journal of Surgical Oncology. 1997, 64: 280-288. 10.1002/(SICI)1096-9098(199704)64:4<280::AID-JSO6>3.0.CO;2-5.CrossRefPubMed Dodd LG, Kerns B-J, Dodge RK, Layfield LJ: Intratumoral Heterogeneity in Primary Breast Carcinoma: Study of Concurrent Parameters. Journal of Surgical Oncology. 1997, 64: 280-288. 10.1002/(SICI)1096-9098(199704)64:4<280::AID-JSO6>3.0.CO;2-5.CrossRefPubMed
2.
go back to reference Sharifi-Salamatian V, de Roquancourt A, Rigaut JP: Breast carcinoma, intratumour heterogeneity and histological grading, using geostatistics. Analytical Cellular Pathology. 2000, IOS Press, 20: 83-91. 0921-8912 Sharifi-Salamatian V, de Roquancourt A, Rigaut JP: Breast carcinoma, intratumour heterogeneity and histological grading, using geostatistics. Analytical Cellular Pathology. 2000, IOS Press, 20: 83-91. 0921-8912
4.
go back to reference Fisher B, Redmond CK: Evolution of Knowledge Related to Breast Cancer Heterogeneity: A 25-Year Retrospective. Journal of Clinical Oncology. 2008, 26 (13): 2068-2071. 10.1200/JCO.2007.14.1804.CrossRefPubMed Fisher B, Redmond CK: Evolution of Knowledge Related to Breast Cancer Heterogeneity: A 25-Year Retrospective. Journal of Clinical Oncology. 2008, 26 (13): 2068-2071. 10.1200/JCO.2007.14.1804.CrossRefPubMed
5.
go back to reference Hans F, Dimitrov S: Histone H3 phosphorylation and cell division. Oncogene. 2001, 20: 3021-3027. 10.1038/sj.onc.1204326.CrossRefPubMed Hans F, Dimitrov S: Histone H3 phosphorylation and cell division. Oncogene. 2001, 20: 3021-3027. 10.1038/sj.onc.1204326.CrossRefPubMed
6.
go back to reference Bossard C: Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index. J Clin Pathol. 2006, 59 (7): 706-10. 10.1136/jcp.2005.030452.PubMedCentralCrossRefPubMed Bossard C: Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index. J Clin Pathol. 2006, 59 (7): 706-10. 10.1136/jcp.2005.030452.PubMedCentralCrossRefPubMed
7.
go back to reference Gosme M: Modélisation du développement spatio-temporel des maladies d’origine tellurique, thèse de doctorat. 2007, Rennes: Université de Rennes I, 198- Gosme M: Modélisation du développement spatio-temporel des maladies d’origine tellurique, thèse de doctorat. 2007, Rennes: Université de Rennes I, 198-
8.
go back to reference Fisher RA: The use of multiple measurements in taxonomic problems. Ann. Eugenics. 1936, 7: 179-188. 10.1111/j.1469-1809.1936.tb02137.x.CrossRef Fisher RA: The use of multiple measurements in taxonomic problems. Ann. Eugenics. 1936, 7: 179-188. 10.1111/j.1469-1809.1936.tb02137.x.CrossRef
9.
go back to reference Marcelpoil R, Usson Y: Methods for the study of cellular sociology: Voronoi diagrams and parametrization of the spatial relationships. J. Theor. Biol. 1992, 154: 359-369. 10.1016/S0022-5193(05)80176-6.CrossRef Marcelpoil R, Usson Y: Methods for the study of cellular sociology: Voronoi diagrams and parametrization of the spatial relationships. J. Theor. Biol. 1992, 154: 359-369. 10.1016/S0022-5193(05)80176-6.CrossRef
10.
go back to reference Haralick RM, Shanmugam K, Dinstein I: Textural features for image classification. IEEE Transaction on Systems, Man and Cybernetics. 1973, 3 (6): 610-621.CrossRef Haralick RM, Shanmugam K, Dinstein I: Textural features for image classification. IEEE Transaction on Systems, Man and Cybernetics. 1973, 3 (6): 610-621.CrossRef
Metadata
Title
Impact of tumor heterogeneity on disease-free survival in a series of 368 patients treated for a breast cancer
Authors
Myriam Oger
Mohamed Allaoui
Nicolas Elie
Jacques Marnay
Paulette Herlin
Benoît Plancoulaine
Jacques Chasle
Véronique Becette
Catherine Bor-Angelier
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue Special Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-S1-S43

Other articles of this Special Issue 1/2013

Diagnostic Pathology 1/2013 Go to the issue