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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-09-2013 | Proceedings

Highlighting peritumoral areas in human skin cancer biopsies by infrared micro-spectroscopy

Authors: David Sebiskveradze, Cyril Gobinet, Valeriu Vrabie, Pierre Jeannesson, Olivier Piot, Michel Manfait

Published in: Diagnostic Pathology | Special Issue 1/2013

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Excerpt

Fourier transform mid-infrared (FT–IR) microspectroscopy is a label-free optical method based on the interaction between an incident light beam and matter. This vibrational spectroscopy permits to probe the biochemical composition of the analyzed sample and thus gives information about the structure of this sample. Associated with an imaging system, FT–IR microspectroscopy of human tissues can be used as a very sensitive, non-destructive and non-subjective tool for the detection and localization of tumoral areas independently of visual morphology. Thus, FT–IR microimaging has demonstrated potential to provide clinically relevant diagnostic information in oncology [1‐3]. …
Literature
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Wolthuis R, Travo A, Nicolet C, Neuville A, Gaub M-P, Guenot D, Ly E, Manfait M, Jeannesson P, Piot O: IR spectral imaging for histopathological characterization of xenografted human colon carcinomas. Anal Chem. 2008, 80: 8461-8469. 10.1021/ac801191x.CrossRefPubMed
2.
Ly E, Piot O, Durlach A, Bernard P, Manfait M: Differential diagnosis of cutaneous carcinomas by infrared spectral micro-imaging combined with pattern recognition. Analyst. 2009, 134: 1208-1214. 10.1039/b820998g.CrossRefPubMed
3.
Travo A, Piot O, Wolthuis R, Gobinet C, Manfait M, Bara J, Forgue-Lafitte M-E, Jeannesson P: IR spectral imaging of secreted mucus: a promising new tool for the histopathological recognition of human colonic adenocarcinomas. Histopathology. 2010, 56: 921-931. 10.1111/j.1365-2559.2010.03563.x.CrossRefPubMed
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Beljebbar A, Dukic S, Amharref N, Bellefqih S, Manfait M: Monitoring of biochemical changes through the C6 gliomas progression and invasion by Fourier transform infrared (FTIR) imaging. Anal Chem. 2009, 81: 9247-9256. 10.1021/ac901464v.CrossRefPubMed
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Untereiner V, Piot O, Diebold MD, Bouché O, Scaglia E, Manfait M: Optical diagnosis of peritoneal metastases by infrared microscopic imaging. Anal Bioanal Chem. 2009, 393: 1619-1627. 10.1007/s00216-009-2630-2.CrossRefPubMed
6.
Sebiskveradze D, Vrabie V, Gobinet C, Durlach A, Bernard P, Ly E, Manfait M, Jeannesson P, Piot O: Automation of an algorithm based on fuzzy clustering for analyzing tumoral heterogeneity in human skin carcinoma tissue sections. Lab Invest. 2011, 91: 799-811. 10.1038/labinvest.2011.13.CrossRefPubMed
7.
Ly E, Piot O, Wolthuis R, Durlach A, Bernard P, Manfait M: Combination of FTIR spectral imaging and chemometrics for tumour detection from paraffin-embedded biopsies. Analyst. 2008, 133: 197-205. 10.1039/b715924b.CrossRefPubMed
Metadata
Title
Highlighting peritumoral areas in human skin cancer biopsies by infrared micro-spectroscopy
Authors
David Sebiskveradze
Cyril Gobinet
Valeriu Vrabie
Pierre Jeannesson
Olivier Piot
Michel Manfait
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue Special Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-S1-S33

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