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Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Case Report

A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review

Authors: Bennani Amal, Hinde El Fatemi, Ihsane Souaf, Kaouthar Moumna, Amarti Affaf

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

Primary leiomyosarcomas of the thyroid gland are extremely rare. we report a case of a 72 year-old women with a painful growing mass of the left neck with skin fistula. The patient underwent a lobectomy. The tumor histology showed spindle-shaped cells arranged in interlacing fascicles that expressed desmine and Hcaldesmone, but were negative for cytokeratins and thyroglobulin. Total body CT scan didnt show any other tumor. The patient died two months after surgery. Primary thyroid leiomyosarcoma may be mistaken for other tumors, such as anaplastic or medullary carcinomas. Therefore, the diagnosis is difficult and requires numerous clinical, radiological, and pathological investigations.

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Literature
1.
go back to reference Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG: Sarcomas of the head and neck: prognostic factors and treatment strategies. Cancer. 1992, 70: 169-177. 10.1002/1097-0142(19920701)70:1<169::AID-CNCR2820700127>3.0.CO;2-F.CrossRefPubMed Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG: Sarcomas of the head and neck: prognostic factors and treatment strategies. Cancer. 1992, 70: 169-177. 10.1002/1097-0142(19920701)70:1<169::AID-CNCR2820700127>3.0.CO;2-F.CrossRefPubMed
2.
go back to reference Saleh HA, Bo J, John B, Opada A: Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules. Diagn Pathol. 2010, 5: 9-10.1186/1746-1596-5-9. (26 January 2010)PubMedCentralCrossRefPubMed Saleh HA, Bo J, John B, Opada A: Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules. Diagn Pathol. 2010, 5: 9-10.1186/1746-1596-5-9. (26 January 2010)PubMedCentralCrossRefPubMed
3.
go back to reference Qingbin S, Deguang W, Yi L, Changsi L, Changqing F, Xiangmin H, Jianhua L: Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China. Diagn Pathol. 2011, 6: 126-10.1186/1746-1596-6-126. (21 December 2011)CrossRef Qingbin S, Deguang W, Yi L, Changsi L, Changqing F, Xiangmin H, Jianhua L: Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China. Diagn Pathol. 2011, 6: 126-10.1186/1746-1596-6-126. (21 December 2011)CrossRef
4.
go back to reference Dina El D, Ahmed N, Salem A: Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. Diagn Pathol. 2008, 3: 5-10.1186/1746-1596-3-5. (6 February 2008)CrossRef Dina El D, Ahmed N, Salem A: Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. Diagn Pathol. 2008, 3: 5-10.1186/1746-1596-3-5. (6 February 2008)CrossRef
5.
go back to reference Xiaoqi L, Bing Z, Yulin L, Silverman JF: Follicular thyroid carcinoma invades venous rather than lymphatic vessels. Diagn Pathol. 2010, 5: 8-10.1186/1746-1596-5-8. (22 January 2010)CrossRef Xiaoqi L, Bing Z, Yulin L, Silverman JF: Follicular thyroid carcinoma invades venous rather than lymphatic vessels. Diagn Pathol. 2010, 5: 8-10.1186/1746-1596-5-8. (22 January 2010)CrossRef
6.
go back to reference Thompson LD, Wenig BM, Adair CF, Shmookler BM, Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer. 1997, 79: 579-587. 10.1002/(SICI)1097-0142(19970201)79:3<579::AID-CNCR22>3.0.CO;2-#.CrossRefPubMed Thompson LD, Wenig BM, Adair CF, Shmookler BM, Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer. 1997, 79: 579-587. 10.1002/(SICI)1097-0142(19970201)79:3<579::AID-CNCR22>3.0.CO;2-#.CrossRefPubMed
7.
go back to reference Andrion A, Bellis D, Delsedime L: Leiomyoma and neurilemoma: report of two unusual non-epithelial tumours of the thyroid gland. Virchows Archiv Pathol Anat. 1988, 413: 367-372. 10.1007/BF00783030.CrossRef Andrion A, Bellis D, Delsedime L: Leiomyoma and neurilemoma: report of two unusual non-epithelial tumours of the thyroid gland. Virchows Archiv Pathol Anat. 1988, 413: 367-372. 10.1007/BF00783030.CrossRef
8.
go back to reference Akcam T, Oysul K, Birkent H: Leiomyosarcoma of the head and neck: report of two cases and review of the literature. Auris Nasus Larynx. 2005, 32: 209-212. 10.1016/j.anl.2005.01.012.CrossRefPubMed Akcam T, Oysul K, Birkent H: Leiomyosarcoma of the head and neck: report of two cases and review of the literature. Auris Nasus Larynx. 2005, 32: 209-212. 10.1016/j.anl.2005.01.012.CrossRefPubMed
9.
go back to reference Lin JD, Weng HF, Ho YS: Clinical and pathological characteristics of secondary thyroid cancer. Thyroid. 1998, 8: 149-153. 10.1089/thy.1998.8.149.CrossRefPubMed Lin JD, Weng HF, Ho YS: Clinical and pathological characteristics of secondary thyroid cancer. Thyroid. 1998, 8: 149-153. 10.1089/thy.1998.8.149.CrossRefPubMed
10.
go back to reference Ordonez NG, El-Naggar AK, Hickey RC: Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am J Clin Pathol. 1991, 96: 15-24.PubMed Ordonez NG, El-Naggar AK, Hickey RC: Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am J Clin Pathol. 1991, 96: 15-24.PubMed
11.
go back to reference Just PA, Guillevin R, Capron F: An unusual clinical presentation of a rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature. An of Diag Path. 2008, 12: 50-56. 10.1016/j.anndiagpath.2006.06.006.CrossRef Just PA, Guillevin R, Capron F: An unusual clinical presentation of a rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature. An of Diag Path. 2008, 12: 50-56. 10.1016/j.anndiagpath.2006.06.006.CrossRef
12.
go back to reference Kamaljeet S, Sharma MC, Deepali J, Rajinder K: Melanotic medullary carcinoma of thyroid – report of a rare case with brief review of literature. Diagn Pathol. 2008, 3: 2-10.1186/1746-1596-3-2. (11 January 2008)CrossRef Kamaljeet S, Sharma MC, Deepali J, Rajinder K: Melanotic medullary carcinoma of thyroid – report of a rare case with brief review of literature. Diagn Pathol. 2008, 3: 2-10.1186/1746-1596-3-2. (11 January 2008)CrossRef
13.
go back to reference Thompson LD, Wenig BM, Adair CF: Primary smooth muscle tumors of the thyroid gland. Cancer. 1997, 79: 579-587. 10.1002/(SICI)1097-0142(19970201)79:3<579::AID-CNCR22>3.0.CO;2-#.CrossRefPubMed Thompson LD, Wenig BM, Adair CF: Primary smooth muscle tumors of the thyroid gland. Cancer. 1997, 79: 579-587. 10.1002/(SICI)1097-0142(19970201)79:3<579::AID-CNCR22>3.0.CO;2-#.CrossRefPubMed
14.
go back to reference Adachi M, Wellmann KF, Garcia R: Metastatic leiomyosarcoma in brain and heart. J Pathol. 1969, 98: 294-296. 10.1002/path.1710980411.CrossRefPubMed Adachi M, Wellmann KF, Garcia R: Metastatic leiomyosarcoma in brain and heart. J Pathol. 1969, 98: 294-296. 10.1002/path.1710980411.CrossRefPubMed
15.
go back to reference Ozaki O, Sugino K, Mimura T: Primary leiomyosarcoma of the thyroid gland. Surg Today. 1997, 27: 177-180. 10.1007/BF02385912.CrossRefPubMed Ozaki O, Sugino K, Mimura T: Primary leiomyosarcoma of the thyroid gland. Surg Today. 1997, 27: 177-180. 10.1007/BF02385912.CrossRefPubMed
Metadata
Title
A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review
Authors
Bennani Amal
Hinde El Fatemi
Ihsane Souaf
Kaouthar Moumna
Amarti Affaf
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-36

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