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Open Access 01-12-2013 | Case Report

Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature

Authors: Liang Wang, Yang Liu, Xuyong Lin, Di Zhang, Qingchang Li, Xueshan Qiu, En-Hua Wang

Published in: Diagnostic Pathology | Issue 1/2013

Abstract

Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior. This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern. Considering the histological features of LGCCC, it should be distinguished with papillocystic variant of acinic cell carcinoma, conventional salivary duct carcinoma, cystadenocarcinoma, polymorphous low-grade adenocarcinoma, carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma. Herein, we presented two cases of LGCCC. One arose in the left parotid region in a 48-year-old male, and the other one arose in the right parotid gland in a 59-year-old female. For both cases, immunohistochemically, the luminal tumor cells showed diffuse expression of CK and S100; p63 and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells. Both patients were alive with no tumor recurrence or metastasis at follow-up.

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Title: Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature
Authors: Liang Wang
Yang Liu
Xuyong Lin
Di Zhang
Qingchang Li
Xueshan Qiu
En-Hua Wang
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-8-28

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Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature

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