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Open Access 01-12-2013 | Case Report

Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location

Authors: Liyan Xue, Zhonghua Luan, Ying Liu, Shuangmei Zou, Jun Jiang, Ning Wu, Ning Lu, Dongmei Lin

Published in: Diagnostic Pathology | Issue 1/2013

Abstract

Tumor-to-tumor metastasis is a fairly rare phenomenon. The lung cancers are the most common donors, but are exceedingly rare as recipients. Here we report a case of a lung adenocarcinoma acting as the recipient of papillary thyroid carcinoma, with multiple spreading foci of the two cancers in the lung simultaneously. The morphology and immunohistochemisty (Napsin-A, Thyroglobulin) are very important in differential diagnosis of lung primary adenocarcinoma and metastatic papillary thyroid carcinoma.

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Petraki C, Vaslamatzis M, Argyrakos T, Petraki K, Strataki M, Alexopoulos C, Sotsiou F: Tumor to tumor metastasis: report of two cases and review of the literature. Int J Surg Pathol. 2003, 11: 127-135. 10.1177/106689690301100214.CrossRefPubMed

Campbell LV, Gilbert E, Chamberlain CR, Watne AL: Metastases of cancer to cancer. Cancer. 1968, 22: 635-643. 10.1002/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O.CrossRefPubMed

Roscoe KJ, Raja S, Tronic B, Dou Y: Single F-18 fluorodeoxyglucose positron emission tomography hypermetabolic focus containing metastatic papillary thyroid cancer within a primary scarring adenocarcinoma lung cancer. Clin Nucl Med. 2006, 31: 359-360. 10.1097/01.rlu.0000219081.67943.90.CrossRefPubMed

Nonomura A, Mizukami Y, Shimizu J, Watanabe Y, Kamimura R, Takashima T: Two patients with metastasis of cancer to other neoplasm: a thyroid carcinoma metastatic to a lung carcinoma and a gastric carcinoma metastatic to a thyroid adenoma. Endocr Pathol. 1994, 5: 233-239. 10.1007/BF02921492.CrossRef

Kim KM, Kim YN, Chu HH, Jin HY, Kim MH, Chung MJ: Papillary carcinoma of thyroid metastatic to adenocarcinoma in situ of lung: report of an unusual case. Korean J Pathol. 2012, 46: 282-286. 10.4132/KoreanJPathol.2012.46.3.282.PubMedCentralCrossRefPubMed

Sella A, Ro JY: Renal cell cancer: best recipient of tumor-to-tumor metastasis. Urology. 1987, 30: 35-38. 10.1016/0090-4295(87)90568-1.CrossRefPubMed

Hashimoto K, Yamamoto H, Nakano T, Oyama M, Shiratsuchi H, Nakashima T, Tamiya S, Komune S, Oda Y: Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma. Pathol Int. 2011, 61: 435-441. 10.1111/j.1440-1827.2011.02679.x.CrossRefPubMed

Baloch ZW, LiVolsi VA: Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med. 1999, 123: 703-706.PubMed

Kameyama K, Kamio N, Okita H, Hata J: Metastatic carcinoma in follicular adenoma of the thyroid gland. Pathol Res Pract. 2000, 196: 333-336. 10.1016/S0344-0338(00)80065-5. discussion 337–338CrossRefPubMed

10.

Stevens TM, Richards AT, Bewtra C, Sharma P: Tumors metastatic to thyroid neoplasms: a case report and review of the literature. Patholog Res Int. 2011, 2011: 238693-PubMedCentralPubMed

11.

Ortega P, Li IY, Shimkin M: Metastasis of neoplasms to other neoplasms. Ann West Med Surg. 1951, 5: 601-609.PubMed

12.

Sugitani I, Fujimoto Y, Yamamoto N: Papillary thyroid carcinoma with distant metastases: survival predictors and the importance of local control. Surgery. 2008, 143: 35-42. 10.1016/j.surg.2007.06.011.CrossRefPubMed

13.

Matos LL, Del Giglio AB, Matsubayashi CO, de Lima Farah M, Del Giglio A, da Silva Pinhal MA: Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis. Diagn Pathol. 2012, 7: 97-10.1186/1746-1596-7-97.PubMedCentralCrossRefPubMed

14.

Song Q, Wang D, Lou Y, Li C, Fang C, He X, Li J: Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China. Diagn Pathol. 2011, 6: 126-10.1186/1746-1596-6-126.PubMedCentralCrossRefPubMed

15.

Bishop JA, Sharma R, Illei PB: Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol. 2010, 41: 20-25. 10.1016/j.humpath.2009.06.014.CrossRefPubMed

16.

Kulkarni A, Pillai R, Ezekiel AM, Henner WD, Handorf CR: Comparison of histopathology to gene expression profiling for the diagnosis of metastatic cancer. Diagn Pathol. 2012, 7: 110-10.1186/1746-1596-7-110.PubMedCentralCrossRefPubMed

Title: Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location
Authors: Liyan Xue
Zhonghua Luan
Ying Liu
Shuangmei Zou
Jun Jiang
Ning Wu
Ning Lu
Dongmei Lin
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-8-26

At a glance: The STEP trials

Springer Medicine

Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location

Abstract

Virtual Slides

At a glance: The STEP trials

Springer Medicine

Abstract

Virtual Slides

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