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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Research

The positive correlations of apolipoprotein E with disease activity and related cytokines in systemic lupus erythematosus

Authors: Li-jun Song, Wei-wei Liu, Yu-chen Fan, Feng Qiu, Qi-lin Chen, Xing-fu Li, Feng Ding

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

Background

The aim of this study is to investigate the expression of apolipoprotein E (apoE) and the relationship between apoE and disease activity of SLE, and the possible effects of glucocorticoid on apoE and other cytokines activities in SLE patients.

Methods

Forty treatment-naïve SLE patients and forty matched healthy controls were studied. All the SLE patients received prednisone 1 mg/kg/day for 28 consecutive days. The sera levels of apoE and related cytokines were evaluated by ELISA. The expression of apoE mRNA in peripheral blood mononuclear cells (PBMCs) was determined by real-time PCR.

Results

Compared with healthy controls, the relative expression levels of ApoE proteins and sera levels were significantly up-regulated in active SLE patients. ApoE sera concentrations positively correlated with SLEDAI, anti-dsDNA antibody and the related cytokines including IL-6, IFN-γ and IL-10, and uncorrelated with the concentration of total cholesterol (TC) and triglyceride (TG) in SLE patients. After 4 weeks prednisone treatment, the relative mRNA expression of apoE and the serum levels of apoE and related cytokines decreased.

Conclusions

ApoE correlated with disease activity and related cytokines in SLE patients. Glucocorticoid can down-regulate the expressions of apoE and related cytokines.

Virtual slide

The virtual slide(s) for this article can be found here:http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​1646714011077325​
Appendix
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Metadata
Title
The positive correlations of apolipoprotein E with disease activity and related cytokines in systemic lupus erythematosus
Authors
Li-jun Song
Wei-wei Liu
Yu-chen Fan
Feng Qiu
Qi-lin Chen
Xing-fu Li
Feng Ding
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-175

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