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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2012

Open Access 01-12-2012 | Case Report

Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

Authors: Gabriella Aquino, Renato Franco, Fioravante Ronconi, Annamaria Anniciello, Luigi Russo, Annarosaria De Chiara, Luigi Panico

Published in: Diagnostic Pathology | Issue 1/2012

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Abstract

Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.

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Metadata
Title
Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
Authors
Gabriella Aquino
Renato Franco
Fioravante Ronconi
Annamaria Anniciello
Luigi Russo
Annarosaria De Chiara
Luigi Panico
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2012
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-7-79

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