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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2010

Open Access 01-12-2010 | Case Report

Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature

Authors: Radan Dzodic, Boban Stanojevic, Vladimir Saenko, Masahiro Nakashima, Ivan Markovic, Gordana Pupic, Marko Buta, Momcilo Inic, Tatiana Rogounovitch, Shunichi Yamashita

Published in: Diagnostic Pathology | Issue 1/2010

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Abstract

The presence of ectopic breast tissue in axillary lymph nodes (ALN) is a benign condition that must be differentiated from primary or metastatic carcinoma. Here we report a patient who underwent excision of enlarged ALN 10 years after she had received surgical treatment of ipsilateral breast for an intracystic intraductal papilloma (IDP). Histological examination of the removed ALN revealed that the proliferative lesion consisted of papillary and tubular structures lined by luminal cuboidal cells and a distinct outer layer of myoepithelial cells resembling IDP of the breast. Immunostaining with a set of immunohistochemical markers including AE/AE3, alpha-smooth muscle actin and p63 in combination with estrogen and progesterone receptors confirmed the diagnosis of ectopic IDP.
This case shows that even though benign proliferative change in ectopic breast tissue is an extremely rare phenomenon, this possibility should be taken into account for correct diagnosis.
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Literature
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Metadata
Title
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature
Authors
Radan Dzodic
Boban Stanojevic
Vladimir Saenko
Masahiro Nakashima
Ivan Markovic
Gordana Pupic
Marko Buta
Momcilo Inic
Tatiana Rogounovitch
Shunichi Yamashita
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2010
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-5-17

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