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Open Access 01-12-2007 | Case Report

Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature

Authors: Luis F Gonzalez-Cuyar, Fabio Tavora, Allen P Burke, Christopher D Gocke, Ann Zimrin, John J Sauk, Xiafeng F Zhao

Published in: Diagnostic Pathology | Issue 1/2007

Abstract

Background

Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.

Methods

Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.

Results

The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.

Conclusion

This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.

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Title: Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature
Authors: Luis F Gonzalez-Cuyar
Fabio Tavora
Allen P Burke
Christopher D Gocke
Ann Zimrin
John J Sauk
Xiafeng F Zhao
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2007
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-2-49

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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