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Published in: Journal of Occupational Medicine and Toxicology 1/2006

Open Access 01-12-2006 | Review

The toxicity of cadmium and resulting hazards for human health

Authors: Johannes Godt, Franziska Scheidig, Christian Grosse-Siestrup, Vera Esche, Paul Brandenburg, Andrea Reich, David A Groneberg

Published in: Journal of Occupational Medicine and Toxicology | Issue 1/2006

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Abstract

Cadmium (Cd) has been in industrial use for a long period of time. Its serious toxicity moved into scientific focus during the middle of the last century. In this review, we discuss historic and recent developments of toxicological and epidemiological questions, including exposition sources, resorption pathways and organ damage processes.
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Literature
1.
2.
go back to reference Stoeppler: Cadmium. In Metals and their compounds in the environment. Edited by: E M. Weinheim , Verlag Chemie; 1991:805–849. Stoeppler: Cadmium. In Metals and their compounds in the environment. Edited by: E M. Weinheim , Verlag Chemie; 1991:805–849.
3.
go back to reference Jin T, Nordberg M, Frech W, Dumont X, Bernard A, Ye TT, Kong Q, Wang Z, Li P, Lundstrom NG, Li Y, Nordberg GF: Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals 2002,15(4):397–410. 10.1023/A:1020229923095PubMedCrossRef Jin T, Nordberg M, Frech W, Dumont X, Bernard A, Ye TT, Kong Q, Wang Z, Li P, Lundstrom NG, Li Y, Nordberg GF: Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals 2002,15(4):397–410. 10.1023/A:1020229923095PubMedCrossRef
4.
go back to reference Schwarz E CMKC: Cadmium. Umwelt-Survey. WaBoLuHefte 1993., 2: Schwarz E CMKC: Cadmium. Umwelt-Survey. WaBoLuHefte 1993., 2:
5.
6.
go back to reference Foulkes EC: Interactions between metals in rat jejunum: implications on the nature of cadmium uptake. Toxicology 1985,37(1–2):117–125. 10.1016/0300-483X(85)90118-0PubMedCrossRef Foulkes EC: Interactions between metals in rat jejunum: implications on the nature of cadmium uptake. Toxicology 1985,37(1–2):117–125. 10.1016/0300-483X(85)90118-0PubMedCrossRef
7.
go back to reference Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M: Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand J Work Environ Health 1998, 24 Suppl 1: 1–51.PubMed Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M: Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand J Work Environ Health 1998, 24 Suppl 1: 1–51.PubMed
8.
go back to reference Flanagan PR, McLellan JS, Haist J, Cherian G, Chamberlain MJ, Valberg LS: Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 1978,74(5 Pt 1):841–846.PubMed Flanagan PR, McLellan JS, Haist J, Cherian G, Chamberlain MJ, Valberg LS: Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 1978,74(5 Pt 1):841–846.PubMed
9.
go back to reference Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997,388(6641):482–488. 10.1038/41343PubMedCrossRef Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997,388(6641):482–488. 10.1038/41343PubMedCrossRef
10.
go back to reference Elinder CG, Lind B, Kjellstrom T, Linnman L, Friberg L: Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch Environ Health 1976,31(6):292–302.PubMedCrossRef Elinder CG, Lind B, Kjellstrom T, Linnman L, Friberg L: Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch Environ Health 1976,31(6):292–302.PubMedCrossRef
11.
go back to reference Barbee JYJ, Prince TS: Acute respiratory distress syndrome in a welder exposed to metal fumes. South Med J 1999,92(5):510–512.PubMedCrossRef Barbee JYJ, Prince TS: Acute respiratory distress syndrome in a welder exposed to metal fumes. South Med J 1999,92(5):510–512.PubMedCrossRef
12.
go back to reference Zalups RK AS: Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 2003,186(3):163–188. 10.1016/S0041-008X(02)00021-2PubMedCrossRef Zalups RK AS: Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 2003,186(3):163–188. 10.1016/S0041-008X(02)00021-2PubMedCrossRef
13.
go back to reference Wester RC, Maibach HI, Sedik L, Melendres J, DiZio S, Wade M: In vitro percutaneous absorption of cadmium from water and soil into human skin. Fundam Appl Toxicol 1992,19(1):1–5. 10.1016/0272-0590(92)90021-9PubMedCrossRef Wester RC, Maibach HI, Sedik L, Melendres J, DiZio S, Wade M: In vitro percutaneous absorption of cadmium from water and soil into human skin. Fundam Appl Toxicol 1992,19(1):1–5. 10.1016/0272-0590(92)90021-9PubMedCrossRef
14.
go back to reference Lansdown AB, Sampson B: Dermal toxicity and percutaneous absorption of cadmium in rats and mice. Lab Anim Sci 1996,46(5):549–554.PubMed Lansdown AB, Sampson B: Dermal toxicity and percutaneous absorption of cadmium in rats and mice. Lab Anim Sci 1996,46(5):549–554.PubMed
15.
go back to reference Fasanya-Odewumi C, Latinwo LM, Ikediobi CO, Gilliard L, Sponholtz G, Nwoga J, Stino F, Hamilton N, Erdos GW: The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration. Int J Mol Med 1998,1(6):1001–1006.PubMed Fasanya-Odewumi C, Latinwo LM, Ikediobi CO, Gilliard L, Sponholtz G, Nwoga J, Stino F, Hamilton N, Erdos GW: The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration. Int J Mol Med 1998,1(6):1001–1006.PubMed
16.
go back to reference Orlowski C, Piotrowski JK: Biological levels of cadmium and zinc in the small intestine of non-occupationally exposed human subjects. Hum Exp Toxicol 2003,22(2):57–63. 10.1191/0960327103ht326oaPubMedCrossRef Orlowski C, Piotrowski JK: Biological levels of cadmium and zinc in the small intestine of non-occupationally exposed human subjects. Hum Exp Toxicol 2003,22(2):57–63. 10.1191/0960327103ht326oaPubMedCrossRef
17.
go back to reference Seidal K, Jorgensen N, Elinder CG, Sjogren B, Vahter M: Fatal cadmium-induced pneumonitis. Scand J Work Environ Health 1993,19(6):429–431.PubMedCrossRef Seidal K, Jorgensen N, Elinder CG, Sjogren B, Vahter M: Fatal cadmium-induced pneumonitis. Scand J Work Environ Health 1993,19(6):429–431.PubMedCrossRef
18.
go back to reference Nordberg GF: Cadmium and health in the 21st century--historical remarks and trends for the future. Biometals 2004,17(5):485–489. 10.1023/B:BIOM.0000045726.75367.85PubMedCrossRef Nordberg GF: Cadmium and health in the 21st century--historical remarks and trends for the future. Biometals 2004,17(5):485–489. 10.1023/B:BIOM.0000045726.75367.85PubMedCrossRef
19.
go back to reference Barbier O, Jacquillet G, Tauc M, Cougnon M, Poujeol P: Effect of heavy metals on, and handling by, the kidney. Nephron Physiol 2005,99(4):p105–10. 10.1159/000083981PubMedCrossRef Barbier O, Jacquillet G, Tauc M, Cougnon M, Poujeol P: Effect of heavy metals on, and handling by, the kidney. Nephron Physiol 2005,99(4):p105–10. 10.1159/000083981PubMedCrossRef
20.
go back to reference Svartengren M, Elinder CG, Friberg L, Lind B: Distribution and concentration of cadmium in human kidney. Environ Res 1986,39(1):1–7. 10.1016/S0013-9351(86)80002-0PubMedCrossRef Svartengren M, Elinder CG, Friberg L, Lind B: Distribution and concentration of cadmium in human kidney. Environ Res 1986,39(1):1–7. 10.1016/S0013-9351(86)80002-0PubMedCrossRef
21.
go back to reference Bernard A: Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals 2004,17(5):519–523. 10.1023/B:BIOM.0000045731.75602.b9PubMedCrossRef Bernard A: Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals 2004,17(5):519–523. 10.1023/B:BIOM.0000045731.75602.b9PubMedCrossRef
22.
go back to reference Hotz P, Buchet JP, Bernard A, Lison D, Lauwerys R: Renal effects of low-level environmental cadmium exposure: 5-year follow-up of a subcohort from the Cadmibel study. Lancet 1999,354(9189):1508–1513. 10.1016/S0140-6736(99)91145-5PubMedCrossRef Hotz P, Buchet JP, Bernard A, Lison D, Lauwerys R: Renal effects of low-level environmental cadmium exposure: 5-year follow-up of a subcohort from the Cadmibel study. Lancet 1999,354(9189):1508–1513. 10.1016/S0140-6736(99)91145-5PubMedCrossRef
23.
go back to reference Piasek M, Laskey JW: Effects of in vitro cadmium exposure on ovarian steroidogenesis in rats. J Appl Toxicol 1999,19(3):211–217. 10.1002/(SICI)1099-1263(199905/06)19:3<211::AID-JAT568>3.0.CO;2-4PubMedCrossRef Piasek M, Laskey JW: Effects of in vitro cadmium exposure on ovarian steroidogenesis in rats. J Appl Toxicol 1999,19(3):211–217. 10.1002/(SICI)1099-1263(199905/06)19:3<211::AID-JAT568>3.0.CO;2-4PubMedCrossRef
24.
go back to reference Henson MC, Chedrese PJ: Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 2004,229(5):383–392. Henson MC, Chedrese PJ: Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 2004,229(5):383–392.
25.
go back to reference Frery N, Nessmann C, Girard F, Lafond J, Moreau T, Blot P, Lellouch J, Huel G: Environmental exposure to cadmium and human birthweight. Toxicology 1993,79(2):109–118. 10.1016/0300-483X(93)90124-BPubMedCrossRef Frery N, Nessmann C, Girard F, Lafond J, Moreau T, Blot P, Lellouch J, Huel G: Environmental exposure to cadmium and human birthweight. Toxicology 1993,79(2):109–118. 10.1016/0300-483X(93)90124-BPubMedCrossRef
26.
go back to reference Shiverick KT, Salafia C: Cigarette smoking and pregnancy I: ovarian, uterine and placental effects. Placenta 1999, 20: 265–272. 10.1053/plac.1998.0377PubMedCrossRef Shiverick KT, Salafia C: Cigarette smoking and pregnancy I: ovarian, uterine and placental effects. Placenta 1999, 20: 265–272. 10.1053/plac.1998.0377PubMedCrossRef
27.
go back to reference Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB: Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 2003,9 (8):1081–1084. 10.1038/nm902PubMedCrossRef Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB: Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 2003,9 (8):1081–1084. 10.1038/nm902PubMedCrossRef
28.
29.
go back to reference Nogawa K, Kobayashi E, Okubo Y, Suwazono Y: Environmental cadmium exposure, adverse effects and preventive measures in Japan. Biometals 2004,17(5):581–587. 10.1023/B:BIOM.0000045742.81440.9cPubMedCrossRef Nogawa K, Kobayashi E, Okubo Y, Suwazono Y: Environmental cadmium exposure, adverse effects and preventive measures in Japan. Biometals 2004,17(5):581–587. 10.1023/B:BIOM.0000045742.81440.9cPubMedCrossRef
30.
go back to reference Kazantzis G: Cadmium, osteoporosis and calcium metabolism. Biometals 2004,17(5):493–498. 10.1023/B:BIOM.0000045727.76054.f3PubMedCrossRef Kazantzis G: Cadmium, osteoporosis and calcium metabolism. Biometals 2004,17(5):493–498. 10.1023/B:BIOM.0000045727.76054.f3PubMedCrossRef
32.
go back to reference Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R: Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group. Lancet 1999,353(9159):1140–1144. 10.1016/S0140-6736(98)09356-8PubMedCrossRef Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R: Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group. Lancet 1999,353(9159):1140–1144. 10.1016/S0140-6736(98)09356-8PubMedCrossRef
33.
go back to reference Berglund M, Akesson A, Bjellerup P, Vahter M: Metal-bone interactions. Toxicol Lett 2000, 112–113: 219–225. 10.1016/S0378-4274(99)00272-6PubMedCrossRef Berglund M, Akesson A, Bjellerup P, Vahter M: Metal-bone interactions. Toxicol Lett 2000, 112–113: 219–225. 10.1016/S0378-4274(99)00272-6PubMedCrossRef
34.
go back to reference Chalkley SR, Richmond J, Barltrop D: Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium. Occup Environ Med 1998,55(7):446–452.PubMedCentralPubMedCrossRef Chalkley SR, Richmond J, Barltrop D: Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium. Occup Environ Med 1998,55(7):446–452.PubMedCentralPubMedCrossRef
35.
go back to reference Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR, Balaschak MS: Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res 1988,48(16):4656–4663.PubMed Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR, Balaschak MS: Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res 1988,48(16):4656–4663.PubMed
36.
go back to reference Sahmoun AE, Case LD, Jackson SA, Schwartz GG: Cadmium and prostate cancer: a critical epidemiologic analysis. Cancer Invest 2005,23(3):256–263.PubMedCrossRef Sahmoun AE, Case LD, Jackson SA, Schwartz GG: Cadmium and prostate cancer: a critical epidemiologic analysis. Cancer Invest 2005,23(3):256–263.PubMedCrossRef
37.
go back to reference Kolonel LN: Association of cadmium with renal cancer. Cancer 1976,37(4):1782–1787. 10.1002/1097-0142(197604)37:4<1782::AID-CNCR2820370424>3.0.CO;2-FPubMedCrossRef Kolonel LN: Association of cadmium with renal cancer. Cancer 1976,37(4):1782–1787. 10.1002/1097-0142(197604)37:4<1782::AID-CNCR2820370424>3.0.CO;2-FPubMedCrossRef
38.
go back to reference Il'yasova D SGG: Cadmium and renal cancer. Toxicol Appl Pharmacol 2005,207(2):179–186. 10.1016/j.taap.2004.12.005PubMedCrossRef Il'yasova D SGG: Cadmium and renal cancer. Toxicol Appl Pharmacol 2005,207(2):179–186. 10.1016/j.taap.2004.12.005PubMedCrossRef
39.
go back to reference Goyer RA, Liu J, Waalkes MP: Cadmium and cancer of prostate and testis. Biometals 2004,17(5):555–558. 10.1023/B:BIOM.0000045738.59708.20PubMedCrossRef Goyer RA, Liu J, Waalkes MP: Cadmium and cancer of prostate and testis. Biometals 2004,17(5):555–558. 10.1023/B:BIOM.0000045738.59708.20PubMedCrossRef
40.
go back to reference Prozialeck WC, Lamar PC: Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin. Biochim Biophys Acta 1999,1451(1):93–100. 10.1016/S0167-4889(99)00077-4PubMedCrossRef Prozialeck WC, Lamar PC: Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin. Biochim Biophys Acta 1999,1451(1):93–100. 10.1016/S0167-4889(99)00077-4PubMedCrossRef
41.
go back to reference Groneberg DA, Nowak D, Wussow A, Fischer A: Chronic cough due to occupational factors. J Occup Med Toxicol1 2005.,1(3): Groneberg DA, Nowak D, Wussow A, Fischer A: Chronic cough due to occupational factors. J Occup Med Toxicol1 2005.,1(3):
42.
go back to reference Groneberg DA, Kraus T, Fischer A: Chronic cough: tobacco smoke, particulate matter, ozone, nitrogen oxides and other environmental factors. J Occup Med Toxicol 2005.,1(4): Groneberg DA, Kraus T, Fischer A: Chronic cough: tobacco smoke, particulate matter, ozone, nitrogen oxides and other environmental factors. J Occup Med Toxicol 2005.,1(4):
43.
go back to reference Wagner U, Staats P, HC Fehmann HC, Fischer AG, Groneberg DA: Functional airway secretion in a rat model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD) . J Occup Med Toxicol 2005.,1(5): Wagner U, Staats P, HC Fehmann HC, Fischer AG, Groneberg DA: Functional airway secretion in a rat model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD) . J Occup Med Toxicol 2005.,1(5):
44.
go back to reference Dalvie MA, Myers JE: The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol 2005.,1(6): Dalvie MA, Myers JE: The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol 2005.,1(6):
45.
go back to reference Yelin E, Katz P, Balmes J, Trupin L, Earnest G, Eisner M, Blanc P: Work Life of Persons with Asthma, Rhinitis, and COPD: A Study Using a National, Population-Based Sample. J Occup Med Toxicol 2005.,1(2): Yelin E, Katz P, Balmes J, Trupin L, Earnest G, Eisner M, Blanc P: Work Life of Persons with Asthma, Rhinitis, and COPD: A Study Using a National, Population-Based Sample. J Occup Med Toxicol 2005.,1(2):
Metadata
Title
The toxicity of cadmium and resulting hazards for human health
Authors
Johannes Godt
Franziska Scheidig
Christian Grosse-Siestrup
Vera Esche
Paul Brandenburg
Andrea Reich
David A Groneberg
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Journal of Occupational Medicine and Toxicology / Issue 1/2006
Electronic ISSN: 1745-6673
DOI
https://doi.org/10.1186/1745-6673-1-22

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