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Published in: Trials 1/2006

Open Access 01-12-2006 | Study protocol

Comparison of Venae Sectio vs. modified Seldinger Technique for Totally Implantable Access Ports; Portas-trial [ISRCTN:52368201]

Authors: P Knebel, B Fröhlich, H-P Knaebel, P Kienle, S Luntz, MW Buchler, CM Seiler

Published in: Trials | Issue 1/2006

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Abstract

Background

The insertion of a Totally Implantable Access Port (TIAP) is a routinely employed technique in patients who need a safe and permanent venous access. The number of TIAP implantations is increasing constantly mainly due to advanced treatment options for malignant diseases. Therefore it is important to identify the implantation technique which has the optimal benefit/risk ratio for the patient.

Study design

A single-centre, randomized, controlled superiority trial to compare two different TIAP implantation techniques. Sample size: 160 patients will be included and randomized intra-operatively. Eligibility criteria: Age equal or older than 18 years, patients scheduled for primary elective implantation of a TIAP in local anaesthesia and a signed informed consent. Primary endpoint: Primary success rate of the randomized technique. Intervention: Venae Sectio in combination with the Seldinger Technique (guide wire and a peel away sheath) will be used to place a TIAP. Reference treatment: Conventional Venae Sectio will be used with a direct insertion of the TIAP without guide wire or peel away sheath. Duration of study: Approximately 20 months.

Organisation/Responsibility

The trial will be conducted in compliance with the protocol and in accordance with the moral, ethical, and scientific principles governing clinical research as set out in the Declaration of Helsinki (1989) and Good Clinical Practice (GCP). The trial will also be carried out in keeping with local and regulatory requirements. The Klinisches Studienzentrum Chirurgie (KSC) – Centre of Clinical Trials in Surgery at the Department of Surgery, University Hospital Heidelberg is responsible for planning and conduction of the trial. Documentation of patient's data will be accomplished via electronical Case Report Files (eCRF) with MACRO®-Software by the KSC. Randomization, data management, monitoring and biometry are provided by the independent Koordinierungszentrum für Klinische Studien (KKS) – Coordination Centre for Clinical Trails at the University of Heidelberg.
Appendix
Available only for authorised users
Literature
1.
Di Carlo I, Cordio S, La Greca G, Privitera G, Russello D, Puleo S, Latteri F: Totally implantable venous access devices implanted surgically: a retrospective study on early and late complications. Arch Surg. 2001, 136: 1050-1053. 10.1001/archsurg.136.9.1050.CrossRefPubMed
2.
Knaebel HP, Marten A, Schmidt J, Hoffmann K, Seiler C, Lindel K, Schmitz-Winnenthal H, Fritz S, Herrmann T, Goldschmidt H, Mansmann U, Debus J, Diehl V, Buchler MW: Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma -- CapRI: study protocol [ISRCTN62866759]. BMC Cancer. 2005, 5: 37-10.1186/1471-2407-5-37.CrossRefPubMedPubMedCentral
3.
Seiler CM, Frohlich BE, Dorsam UJ, Kienle P, Buchler MW, Knaebel HP: Surgical technique for totally implantable access ports (TIAP) needs improvement: a multivariate analysis of 400 patients. J Surg Oncol. 2006, 93: 24-29. 10.1002/jso.20410.CrossRefPubMed
4.
Seiler CM, Wente MN, Diener MK, Frohlich BE, Buchler MW, Knaebel HP: Center for clinical studies in a surgical department-An approach for more evidence-based medicine. Contemp Clin Trials. 2005
Metadata
Title
Comparison of Venae Sectio vs. modified Seldinger Technique for Totally Implantable Access Ports; Portas-trial [ISRCTN:52368201]
Authors
P Knebel
B Fröhlich
H-P Knaebel
P Kienle
S Luntz
MW Buchler
CM Seiler
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Trials / Issue 1/2006
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-7-20

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