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Published in: Trials 1/2012

Open Access 01-12-2012 | Study protocol

Mindfulness-based cognitive therapy for multiple chemical sensitivity: a study protocol for a randomized controlled trial

Authors: Christian Riise Hauge, Peter Jensa E Bonde, Alice Rasmussen, Sine Skovbjerg

Published in: Trials | Issue 1/2012

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Abstract

Background

Multiple chemical sensitivity (MCS) is a condition characterized by recurrent, self-reported symptoms from multiple organ systems, attributable to exposure to a wide range of chemically unrelated substances at low levels. The pathophysiology is unknown, and affected individuals generally favor avoidance of the symptom triggering substances as a coping strategy. The impact of MCS on daily life may thus be severe. An intervention that may effectively reduce the impact of MCS, alleviate the symptoms and the psychological distress associated with the condition is therefore highly needed. In this study we will assess the effects of a mindfulness-based cognitive (MBCT) program on MCS.

Methods/Design

Using a randomized controlled design (RCT), we will compare MBCT with treatment as usual (TAU). The MBCT intervention will include 8 weekly 2.5 hour sessions, and 45 minutes of mindfulness home practice 6 days each week. Participants will be asked to complete questionnaires at baseline, post-treatment, and at 6 and 12 months’ follow-up. Based on sample size estimation, 82 participants will be randomized to either the MBCT intervention or to TAU. The primary outcome will be a measure of the impact of MCS on the participants’ lives. The secondary outcome measures are physical symptoms of psychological distress, perceived stress, illness perceptions, QOL, and work ability. Lastly, we will assess whether any effect of MBCT on the primary effect measure is mediated by level of mindfulness, self-compassion, perceived stress, and rumination.

Discussion

This trial will provide important information on the effects of MBCT on MCS.

Trials registration

Clinical trials identifier NCT01240395
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Metadata
Title
Mindfulness-based cognitive therapy for multiple chemical sensitivity: a study protocol for a randomized controlled trial
Authors
Christian Riise Hauge
Peter Jensa E Bonde
Alice Rasmussen
Sine Skovbjerg
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Trials / Issue 1/2012
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-13-179

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