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Published in: Trials 1/2012

Open Access 01-12-2012 | Research

DiAlert: a prevention program for overweight first degree relatives of type 2 diabetes patients: results of a pilot study to test feasibility and acceptability

Authors: Wieke H Heideman, Maartje de Wit, Barend JC Middelkoop, Vera Nierkens, Karien Stronks, Arnoud P Verhoeff, Frank J Snoek

Published in: Trials | Issue 1/2012

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Abstract

Background

Prevalence of type 2 diabetes mellitus is increasing due to lifestyle changes, particularly affecting those genetically at risk. We developed DiAlert as a targeted group-based intervention aimed to promote intrinsic motivation and action planning for lifestyle changes and weight loss in first degree relatives of patients with type 2 diabetes mellitus.
The main objective of the pilot of the DiAlert intervention was to assess fidelity, feasibility and acceptability prior to starting the randomized controlled trial.

Methods

Individuals with a family history of type 2 diabetes mellitus were self-identified and screened for eligibility. DiAlert consists of two group sessions. Feasibility, fidelity, acceptability and self-reported perceptions and behavioral determinants were evaluated in a pre-post study using questionnaires and observations. Determinants of behavior change were analyzed using paired-samples t tests and Wilcoxon signed rank tests.

Results

DiAlert was delivered to two groups of first degree relatives of patients with type 2 diabetes mellitus (N = 9 and N = 12). Feasibility and fidelity were confirmed. Overall, the DiAlert group sessions were positively evaluated (8.0 on a scale of 1 to 10) by participants. The intervention did not impact perceived susceptibility or worry about personal diabetes risk. Action planning with regard to changing diet and physical activity increased.

Conclusions

DiAlert proved feasible and was well-accepted by participants. Positive trends in action planning indicate increased likelihood of actual behavior change following DiAlert. Testing the effectiveness in a randomized controlled trial is imperative.

Trial registration

Netherlands National Trial Register (NTR): NTR2036
Appendix
Available only for authorised users
Literature
1.
Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004, 27: 1047-1053. 10.2337/diacare.27.5.1047.CrossRefPubMed
2.
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403.CrossRefPubMed
3.
Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.CrossRefPubMed
4.
Yates T, Khunti K, Davis M: Prevention of diabetes: a reality in primary care?. Prim Care Diabetes. 2007, 1: 119-121. 10.1016/j.pcd.2007.07.003.CrossRefPubMed
5.
Rosal MC, Benjamin EM, Pekow PS, Lemon SC, von Goeler D: Opportunities and challenges for diabetes prevention at two community health centers. Diabetes Care. 2008, 31: 247-254.CrossRefPubMed
6.
Simmons RK, Griffin SJ, Wareham NJ: Researching how to realize the potential of diabetes prevention. Diabet Med. 2007, 24: 1055-1057. 10.1111/j.1464-5491.2007.02260.x.CrossRefPubMed
7.
Heideman WH, Nierkens V, Stronks K, Middelkoop BJ, Twisk JW, Verhoeff AP, de Wit M, Snoek FJ: DiAlert: a lifestyle education programme aimed at people with a positive family history of type 2 diabetes and overweight, study protocol of a randomised controlled trial. BMC Publ Health. 2011, 11: 751-10.1186/1471-2458-11-751.CrossRef
8.
Davies MJ, Heller S, Skinner TC, Campbell MJ, Carey ME, Cradock S, Dallosso HM, Daly H, Doherty Y, Eaton S, Fox C, Oliver L, Rantell K, Rayman G, Khunti K, Diabetes Education and Self Management for Ongoing and Newly Diagnosed Collaborative: Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial. BMJ. 2008, 336: 491-495. 10.1136/bmj.39474.922025.BE.CrossRefPubMedPubMedCentral
9.
Leibbrandt AJ, Kiefte-de Jong JC, Hogenelst MH, Snoek FJ, Weijs PJ: Effects of the PRo-active Interdisciplinary Self-MAnagement (PRISMA, Dutch DESMOND) program on dietary intake in type 2 diabetes outpatients: a pilot study. Clin Nutr. 2010, 29: 199-205. 10.1016/j.clnu.2009.08.009.CrossRefPubMed
10.
Heideman WH, Middelkoop BJ, Nierkens V, Stronks K, Verhoeff AP, van Esch SC, Snoek FJ: Changing the odds. What do we learn from prevention studies targeted at people with a positive family history of type 2 diabetes?. Prim Care Diabetes. 2011, 5: 215-221. 10.1016/j.pcd.2011.06.004.CrossRefPubMed
11.
Schwarzer R: Modeling health behavior change: how to predict and modify adoption and maintenance of health behaviors. Appl Psychol. 2008, 57: 1-29.
12.
Craig P, Dieppe P, Macintyre S, Mitchie S, Nazareth I, Petticrew M: Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ. 2008, 337: a1655-10.1136/bmj.a1655.CrossRefPubMedPubMedCentral
13.
Claassen L, Henneman L, Kindt I, Marteau TM, Timmermans DR: Perceived risk and representations of cardiovascular disease and preventive behaviour in people diagnosed with familial hypercholesterolemia: a cross-sectional questionnaire study. J Health Psychol. 2010, 15: 33-43. 10.1177/1359105309345170.CrossRefPubMed
14.
Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D: The revised Illness Perception Questionnaire (IPQ-R). Psychol Health. 2002, 17: 1-16. 10.1080/08870440290001494.CrossRef
15.
16.
17.
Gollwitzer PM, Sheeran P: Implementation intentions and goal achievement: a meta-analysis of effects and processes. Adv Exp Soc Psychol. 2006, 38: 69-119.CrossRef
18.
Pijl M, Timmermans DR, Claassen L, Janssens AC, Nijpels G, Dekker JM, Marteau TM, Henneman L: Impact of communicating familial risk of diabetes on illness perceptions and self-reported behavioral outcomes: a randomized controlled trial. Diabetes Care. 2009, 32: 597-599. 10.2337/dc08-1049.CrossRefPubMedPubMedCentral
19.
Qureshi N, Kai J: Informing patients of familial diabetes mellitus risk: how do they respond? A cross-sectional survey. BMC Health Serv Res. 2008, 8: 37-10.1186/1472-6963-8-37.CrossRefPubMedPubMedCentral
20.
Nishigaki M, Sato E, Ochiai R, Shibayama T, Kazuma K: Impact of a booklet about diabetes genetic susceptibility and its prevention on attitudes towards prevention and perceived behavioral change in patients with type 2 diabetes and their offspring. Adv Prev Med. 2011, 201 (1): 365132-
21.
Pierce M, Ridout D, Harding D, Keen H, Bradley C: More good than harm: a randomised controlled trial of the effect of education about familial risk of diabetes on psychological outcomes. Br J Gen Pract. 2000, 50: 867-871.PubMedPubMedCentral
Metadata
Title
DiAlert: a prevention program for overweight first degree relatives of type 2 diabetes patients: results of a pilot study to test feasibility and acceptability
Authors
Wieke H Heideman
Maartje de Wit
Barend JC Middelkoop
Vera Nierkens
Karien Stronks
Arnoud P Verhoeff
Frank J Snoek
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Trials / Issue 1/2012
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-13-178

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