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Published in: Trials 1/2011

Open Access 01-12-2011 | Study protocol

To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised trial

Authors: Margaret Pinder, Musa Jawara, Lamin BS Jarju, Ballah Kandeh, David Jeffries, Manuel F Lluberas, Jenny Mueller, David Parker, Kalifa Bojang, David J Conway, Steve W Lindsay

Published in: Trials | Issue 1/2011

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Abstract

Background

Recently, there has been mounting interest in scaling-up vector control against malaria in Africa. It needs to be determined if indoor residual spraying (IRS with DDT) will provide significant marginal protection against malaria over current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in a controlled trial, given that DDT is currently the most persistent insecticide for IRS.

Methods

A 2 armed cluster-randomised controlled trial will be conducted to assess whether DDT IRS and LLINs combined provide better protection against clinical malaria in children than LLINs alone in rural Gambia. Each cluster will be a village, or a group of small adjacent villages; all clusters will receive LLINs and half will receive IRS in addition. Study children, aged 6 months to 13 years, will be enrolled from all clusters and followed for clinical malaria using passive case detection to estimate malaria incidence for 2 malaria transmission seasons in 2010 and 2011. This will be the primary endpoint. Exposure to malaria parasites will be assessed using light and exit traps followed by detection of Anopheles gambiae species and sporozoite infection. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection and the prevalence of anaemia.

Discussion

Practical issues concerning intervention implementation, as well as the potential benefits and risks of the study, are discussed.

Trial Registration

ISRCTN01738840 - Spraying And Nets Towards malaria Elimination (SANTE)
Appendix
Available only for authorised users
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Metadata
Title
To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised trial
Authors
Margaret Pinder
Musa Jawara
Lamin BS Jarju
Ballah Kandeh
David Jeffries
Manuel F Lluberas
Jenny Mueller
David Parker
Kalifa Bojang
David J Conway
Steve W Lindsay
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Trials / Issue 1/2011
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-12-147

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