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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2011

Open Access 01-12-2011 | Research

Cognitive-electrophysiological indices of attentional and inhibitory processing in adults with ADHD: familial effects

Authors: Gráinne McLoughlin, Philip Asherson, Bjoern Albrecht, Tobias Banaschewski, Aribert Rothenberger, Daniel Brandeis, Jonna Kuntsi

Published in: Behavioral and Brain Functions | Issue 1/2011

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Abstract

Background

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that starts in childhood and frequently persists in adults. In a comparison of adults with ADHD and a matched control sample, we previously showed that abnormal inhibitory processing is typically preceded or accompanied by other processing deficits in adult ADHD. We now compare these data further to additional data from first-degree relatives (fathers) of children with ADHD to identify whether this pattern of abnormal processing shares familial influences with ADHD in adults.

Methods

Using a family design, we compared 20 fathers of children with the combined subtype of ADHD with 21 adults with ADHD combined subtype and 20 controls in event-related potential indices of preparatory states and subsequent response inhibition processing as elicited by a cued continuous performance task.

Results

Fathers of children with ADHD exhibited significantly weaker orienting attention to cues and inhibitory processing than the controls but not the ADHD sample.

Conclusions

These findings provide evidence for the familial association of attentional orienting and response inhibition processes with ADHD in adults and indicate a familial and neurobiological link between ADHD in children and adults.
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Metadata
Title
Cognitive-electrophysiological indices of attentional and inhibitory processing in adults with ADHD: familial effects
Authors
Gráinne McLoughlin
Philip Asherson
Bjoern Albrecht
Tobias Banaschewski
Aribert Rothenberger
Daniel Brandeis
Jonna Kuntsi
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2011
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/1744-9081-7-26

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