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Behavioral and Brain Functions

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Open Access 01-12-2010 | Research

Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder

Authors: Xiaohui Xu, Gerome Breen, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, Philip Asherson

Published in: Behavioral and Brain Functions | Issue 1/2010

Abstract

Background

The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances. A recent study has reported that a polymorphism (rs1801260) at the 3'-untranslated region of the CLOCK gene is associated with adult ADHD.

Methods

To investigate the association between the polymorphism (rs1801260) in ADHD, two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped and analysed using within-family transmission disequilibrium test (TDT). Bonferroni correction procedures were used to just for multiple comparisons.

Results

We found evidence of increased transmission of the T allele of the rs1801260 polymorphism in Taiwanese samples (P = 0.010). There was also evidence of preferential transmission of the T allele of the rs1801260 polymorphism in combined samples from the Taiwan and UK (P = 0.008).

Conclusion

This study provides evidence for the possible involvement of CLOCK in susceptibility to ADHD.

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Title: Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder
Authors: Xiaohui Xu
Gerome Breen
Chih-Ken Chen
Yu-Shu Huang
Yu-Yu Wu
Philip Asherson
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Behavioral and Brain Functions / Issue 1/2010
Electronic ISSN: 1744-9081
DOI: https://doi.org/10.1186/1744-9081-6-48

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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