Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2008

Open Access 01-12-2008 | Research

Speech identification and cortical potentials in individuals with auditory neuropathy

Authors: Vijaya kumar Narne, CS Vanaja

Published in: Behavioral and Brain Functions | Issue 1/2008

Login to get access

Abstract

Background

Present study investigated the relationship between speech identification scores in quiet and parameters of cortical potentials (latency of P1, N1, and P2; and amplitude of N1/P2) in individuals with auditory neuropathy.

Methods

Ten individuals with auditory neuropathy (five males and five females) and ten individuals with normal hearing in the age range of 12 to 39 yr participated in the study. Speech identification ability was assessed for bi-syllabic words and cortical potentials were recorded for click stimuli.

Results

Results revealed that in individuals with auditory neuropathy, speech identification scores were significantly poorer than that of individuals with normal hearing. Individuals with auditory neuropathy were further classified into two groups, Good Performers and Poor Performers based on their speech identification scores. It was observed that the mean amplitude of N1/P2 of Poor Performers was significantly lower than that of Good Performers and those with normal hearing. There was no significant effect of group on the latency of the peaks. Speech identification scores showed a good correlation with the amplitude of cortical potentials (N1/P2 complex) but did not show a significant correlation with the latency of cortical potentials.

Conclusion

Results of the present study suggests that measuring the cortical potentials may offer a means for predicting perceptual skills in individuals with auditory neuropathy.
Appendix
Available only for authorised users
Literature
1.
Starr A, Michalewski HJ, Zeng FG, FujiKawa-Brooks S, Lithicum F, Kim CS, Winner D, Keats B: Pathology and physiology of AN with novel mutation in the MPZ gene (tyr145->ser). Brain. 2003, 126: 1604-1619. 10.1093/brain/awg156.CrossRefPubMed
2.
Zeng FG, Kong YY, Michalewski HJ, Starr A: Perceptual consequences of disrupted auditory nerve activity. J Neurohysiol. 2005, 93 (6): 3050-3063. 10.1152/jn.00985.2004.CrossRef
3.
Sininger Y, Oba S: Patients with AN: who are they and what can they hear?. A new perspective on hearing disorders. Edited by: Sininger Y, Starr A. 2001, Sandigo: Singular-Thomson learning, 15-35.
4.
Zeng FG, Oba S, Grade S, Sininger Y, Starr A: Temporal and speech processing deficits in AN. Neuroreport. 1999, 10: 3429-3435.CrossRefPubMed
5.
Starr A, Picton TW, Sininger S, Hood LJ, Berlin CI: Auditory Neuropathy. Brain. 1996, 119: 741-753. 10.1093/brain/119.3.741.CrossRefPubMed
6.
Kraus N, Bradlow MA, Cunningham CJ, King CD, Koch DB, Nicol TG, Mcgee TJ, Stein LK, Wright BA: Consequences of neural asynchrony: A case of AN. J Assoc Res Otolaryngol. 2000, 01: 33-45. 10.1007/s101620010004.CrossRef
7.
Rance G, Cone-Wession B, Shepherd RK, Dowell RC, King AM, Rickards FW, Clark GM: Speech perception and cortical event related potentials in children with AN. Ear Hear. 2002, 25: 34-46. 10.1097/01.AUD.0000111259.59690.B8.CrossRef
8.
Vanaja CS, Manjula P: LLR as a measure of benefit derived from hearing devices with auditory dys-synchrony. first conference on Auditory Neuropathy. Edited by: Shivashanker N, Shashikala HR. 2004, Bangalore: Department of Speech pathology and Audiology, National Institute of Mental Health and Neuro sciences, 136-146.
9.
Vandana : Speech identification test in Kannada. 1998, Unpublished independent project, University of Mysore, Mysore, India
10.
American National Standards Institute: Maximum permissible ambient noise for audiometric rooms. ANSI S3.1-1999. New York: American National Standards Institute
11.
American National Standards Institute: Specification for audiometers. ANSI S3.6-1996. New York: American National Standards Institute
12.
Vanaja CS, Jayaram M: Sensitivity and specificity of audiological tests. 2003, Unpublished Project Report, All India Institute of Speech and Hearing, Mysore, India
13.
Yellin MW, Jerger J, Fifer RC: Norms for disproportionate loss in speech intelligibility. Ear Hear. 1989, 10: 231-234. 10.1097/00003446-198908000-00003.CrossRefPubMed
14.
15.
Oates P, Kurtzberg D, Stapells DR: Effect of sensoryneural hearing loss on cortical event-related potentials behavioral measures of sound processing. Ear Hear. 2002, 23: 399-415. 10.1097/00003446-200210000-00002.CrossRefPubMed
16.
Hall JW: Effect of nonpathologic subject characteristics. Edited by: Allyn & Bacon. 1992, Handbook of auditory evoked responses, 70-103.
17.
Satya-Murthi S, Wolpaw JR, Cacace AT, Scharffer CA: Late auditory evoked potentials can occur without brain stem potentials. Electroencephalogr Clin Neurophysiol. 1983, 56: 304-307. 10.1016/0013-4694(83)90255-9.CrossRef
18.
Hendler T, Squires NK, Moore JK, Coyle PK: Auditory evoked potentials in multiple sclerosis: correlation with magnetic resonance imaging. J Basic Clin Physiol Pharmacol. 1996, 7: 245-278.CrossRefPubMed
19.
Japaridze G, Shakarishvili R, Kevanishvili Z: Auditory brainstem, middle-latency, and slow cortical responses in multiple sclerosis. Acta Neurol Scand. 2002, 106: 47-53. 10.1034/j.1600-0404.2002.01226.x.CrossRefPubMed
20.
Mc Donald WI, Sears TA: The effect of experimental demyelination on conduction in the central nerves system. Brain. 1970, 91: 583-595. 10.1093/brain/93.3.583.CrossRef
21.
Rapin I, Gravel J: "Auditory neuropathy": Physiologic and pathologic evidence calls for more diagnostic specificity. Int J Pediatr Otorhinolaryngol. 2003, 67: 707-728. 10.1016/S0165-5876(03)00103-4.CrossRefPubMed
22.
Giraud AL, Lorenzi C, Ashburner J, Wable J, Johnsrude I, Frackowiak R, Kleinschmidt R: Representation of the Temporal Envelope of Sounds in the Human Brain. J Neurophysiol. 2000, 84: 1588-1598.PubMed
23.
Drullman R, Festen JM, Plomp R: Effect of temporal envelope smearing on speech reception. J Acoust Soc Am. 1994, 95: 1053-1064. 10.1121/1.408467.CrossRefPubMed
Metadata
Title
Speech identification and cortical potentials in individuals with auditory neuropathy
Authors
Vijaya kumar Narne
CS Vanaja
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2008
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/1744-9081-4-15

Other articles of this Issue 1/2008

Behavioral and Brain Functions 1/2008 Go to the issue

Research

Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long-term effects

Research

Individual preferences modulate incentive values: Evidence from functional MRI

Research

Cognitive development in children with chronic protein energy malnutrition

Research

When moving faces activate the house area: an fMRI study of object-file retrieval

Research

Context and strain-dependent behavioral response to stress

Research

Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test