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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2007

Open Access 01-12-2007 | Research

A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males

Authors: Kevin M Beaver, John Paul Wright, Matt DeLisi, Anthony Walsh, Michael G Vaughn, Danielle Boisvert, Jamie Vaske

Published in: Behavioral and Brain Functions | Issue 1/2007

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Abstract

Background

Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene × gene interactions in the etiology of conduct disorder and antisocial behavior. This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 receptor polymorphism (DRD4).

Methods

A sample of 872 male participants from the National Longitudinal Study of Adolescent Health (Add Health) completed self-report questionnaires that tapped adolescent conduct disorder and adult antisocial behavior. DNA was genotyped for DRD2 and DRD4.

Results

Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior.

Conclusion

The results suggest that a gene × gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.
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Metadata
Title
A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males
Authors
Kevin M Beaver
John Paul Wright
Matt DeLisi
Anthony Walsh
Michael G Vaughn
Danielle Boisvert
Jamie Vaske
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2007
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/1744-9081-3-30

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