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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2013

Open Access 01-12-2013 | Primary research

Dysfunction of orbitofrontal and dorsolateral prefrontal cortices in children and adolescents with high-functioning pervasive developmental disorders

Authors: Tetsuji Sawa, Masaki Kodaira, Arata Oiji, Daimei Sasayama, Yoshitaka Iwadare, Hirokage Ushijima, Masahide Usami, Kyota Watanabe, Kazuhiko Saito

Published in: Annals of General Psychiatry | Issue 1/2013

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Abstract

Background

Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). The purpose of this study was to investigate neuropsychological dysfunctions in both the DLPFC and OFC of children and adolescents with high-functioning PDD.

Methods

The Iowa gambling task (IGT), which reflects OFC function, and the Wisconsin Card Sorting Test (WCST), which reflects DLPFC function, were assigned to 19 children and early adolescents with high-functioning PDD and 19 healthy controls matched for gender, age, and intelligence.

Results

Compared to healthy controls, patients with high-functioning PDD displayed poorer performance on the IGT and the WCST.

Conclusions

These results indicate that both the DLPFC and OFC could be impaired in children and early adolescents with high-functioning PDD.
Appendix
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Metadata
Title
Dysfunction of orbitofrontal and dorsolateral prefrontal cortices in children and adolescents with high-functioning pervasive developmental disorders
Authors
Tetsuji Sawa
Masaki Kodaira
Arata Oiji
Daimei Sasayama
Yoshitaka Iwadare
Hirokage Ushijima
Masahide Usami
Kyota Watanabe
Kazuhiko Saito
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2013
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/1744-859X-12-31

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