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Molecular Pain
Published in: Molecular Pain 1/2008

Open Access 01-12-2008 | Research

Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats

Authors: Jin-Yan Wang, Han-Ti Zhang, Jing-Yu Chang, Donald J Woodward, Luiz A Baccalá, Fei Luo

Published in: Molecular Pain | Issue 1/2008

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Abstract

Background

Expectation is a very potent pain modulator in both humans and animals. There is evidence that pain transmission neurons are modulated by expectation preceding painful stimuli. Nonetheless, few studies have examined the influence of pain expectation on the pain-related neuronal activity and the functional connectivity within the central nociceptive network.

Results

This study used a tone-laser conditioning paradigm to establish the pain expectation in rats, and simultaneously recorded the anterior cingulate cortex (ACC), the medial dorsal thalamus (MD), and the primary somatosensory cortex (SI) to investigate the effect of pain expectation on laser-induced neuronal responses. Cross-correlation and partial directed coherence analysis were used to determine the functional interactions within and between the recorded areas during nociceptive transmission. The results showed that under anticipation condition, the neuronal activity to the auditory cue was significantly increased in the ACC area, whereas those to actual noxious stimuli were enhanced in all the recorded areas. Furthermore, neuronal correlations within and between these areas were significantly increased under conditions of expectation compared to those under non-expectation conditions, indicating an enhanced synchronization of neural activity within the pain network. In addition, information flow from the medial (ACC and MD) to the lateral (SI cortex) pain pathway increased, suggesting that the emotion-related neural circuits may modulate the neuronal activity in the somatosensory pathway during nociceptive transmission.

Conclusion

These results demonstrate that the nociceptive processing in both medial and lateral pain systems is modulated by the expectation of pain.
Appendix
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Metadata
Title
Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats
Authors
Jin-Yan Wang
Han-Ti Zhang
Jing-Yu Chang
Donald J Woodward
Luiz A Baccalá
Fei Luo
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2008
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-4-34

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