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Fluids and Barriers of the CNS
Published in: Fluids and Barriers of the CNS 1/2010

Open Access 01-12-2010 | Review

The function and structure of the cerebrospinal fluid outflow system

Author: Michael Pollay

Published in: Fluids and Barriers of the CNS | Issue 1/2010

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Abstract

This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems are evaluated as to the dominance of one over the other in various species and degree of animal maturation. The functional capabilities of the total CSF drainage system are presented, with evidence that the duality of the system is supported by the changes in fluid outflow dynamics in human and sub-human primates in hydrocephalus. The review also reconciles the relative importance and alterations of each of the outflow systems in a variety of clinical pathological conditions.
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Metadata
Title
The function and structure of the cerebrospinal fluid outflow system
Author
Michael Pollay
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Fluids and Barriers of the CNS / Issue 1/2010
Electronic ISSN: 2045-8118
DOI
https://doi.org/10.1186/1743-8454-7-9

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