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Open Access 01-12-2007 | Review

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Authors: Zeshan Ahmed, Ian RA Mackenzie, Michael L Hutton, Dennis W Dickson

Published in: Journal of Neuroinflammation | Issue 1/2007

Abstract

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency. Little is known about the normal function of PGRN in the central nervous system apart from a role in brain development. It is expressed by microglia and neurons. In the periphery, PGRN is involved in wound repair and inflammation. High PGRN expression has been associated with more aggressive growth of various tumors. The properties of full length PGRN are distinct from those of proteolytically derived peptides, referred to as granulins (GRNs). While PGRN has trophic properties, GRNs are more akin to inflammatory mediators such as cytokines. Loss of the neurotrophic properties of PGRN may play a role in selective neuronal degeneration in FTLD, but neuroinflammation may also be important. Gene expression studies suggest that PGRN is up-regulated in a variety of neuroinflammatory conditions, and increased PGRN expression by microglia may play a pivotal role in the response to brain injury, neuroinflammation and neurodegeneration.

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Title: Progranulin in frontotemporal lobar degeneration and neuroinflammation
Authors: Zeshan Ahmed
Ian RA Mackenzie
Michael L Hutton
Dennis W Dickson
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2007
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-4-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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