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BMC Medicine
Published in: BMC Medicine 1/2011

Open Access 01-12-2011 | Minireview

Advances in understanding ischemic acute kidney injury

Authors: Raj Munshi, Christine Hsu, Jonathan Himmelfarb

Published in: BMC Medicine | Issue 1/2011

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Abstract

Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.
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Metadata
Title
Advances in understanding ischemic acute kidney injury
Authors
Raj Munshi
Christine Hsu
Jonathan Himmelfarb
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2011
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-9-11

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