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Open Access 01-12-2014 | Research article

Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

Authors: Georgina M Hosang, Celia Shiles, Katherine E Tansey, Peter McGuffin, Rudolf Uher

Published in: BMC Medicine | Issue 1/2014

Abstract

Background

Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has received much attention. The aim of the present work was to review and conduct a meta-analysis on the results from published studies examining this interaction.

Methods

A literature search was conducted using PsychINFO and PubMed databases until 22 November 2013. A total of 22 studies with a pooled total of 14,233 participants met the inclusion criteria, the results of which were combined and a meta-analysis performed using the Liptak-Stouffer z-score method.

Results

The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). When the studies were stratified by type of environmental stressor, the evidence was stronger for an interaction with stressful life events (P = 0.01) and weaker for interaction of BDNF Val66Met with childhood adversity (P = 0.051).

Conclusions

The interaction between BDNF and life stress in depression is stronger for stressful life events rather than childhood adversity. Methodological limitations of existing studies include poor measurement of life stress.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/12/7/prepub

Title: Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis
Authors: Georgina M Hosang
Celia Shiles
Katherine E Tansey
Peter McGuffin
Rudolf Uher
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2014
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-12-7

ACC 2024 Congress

Springer Medicine

Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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