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Open Access 01-12-2013 | Research article

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

Authors: Andrea C Tricco, Ayman Chit, Charlene Soobiah, David Hallett, Genevieve Meier, Maggie H Chen, Mariam Tashkandi, Chris T Bauch, Mark Loeb

Published in: BMC Medicine | Issue 1/2013

Abstract

Background

Influenza vaccines are most effective when the antigens in the vaccine match those of circulating strains. However, antigens contained in the vaccines do not always match circulating strains. In the present work we aimed to examine the vaccine efficacy (VE) afforded by influenza vaccines when they are not well matched to circulating strains.

Methods

We identified randomized clinical trials (RCTs) through MEDLINE, EMBASE, the Cochrane Library, and references of included RCTs. RCTs reporting laboratory-confirmed influenza among healthy participants vaccinated with antigens of matching and non-matching influenza strains were included. Two independent reviewers screened citations/full-text articles, abstracted data, and appraised risk of bias. Conflicts were resolved by discussion. A random effects meta-analysis was conducted. VE was calculated using the following formula: (1 - relative risk × 100%).

Results

We included 34 RCTs, providing data on 47 influenza seasons and 94,821 participants. The live-attenuated influenza vaccine (LAIV) showed significant protection against mismatched (six RCTs, VE 54%, 95% confidence interval (CI) 28% to 71%) and matched (seven RCTs, VE 83%, 95% CI 75% to 88%) influenza strains among children aged 6 to 36 months. Differences were observed between the point estimates for mismatched influenza A (five RCTs, VE 75%, 95% CI 41% to 90%) and mismatched influenza B (five RCTs, VE 42%, 95% CI 22% to 56%) estimates among children aged 6 to 36 months. The trivalent inactivated vaccine (TIV) also afforded significant protection against mismatched (nine RCTs, VE 52%, 95% CI 37% to 63%) and matched (eight RCTs, VE 65%, 95% CI 54% to 73%) influenza strains among adults. Numerical differences were observed between the point estimates for mismatched influenza A (five RCTs, VE 64%, 95% CI 23% to 82%) and mismatched influenza B (eight RCTs, VE 52%, 95% CI 19% to 72%) estimates among adults. Statistical heterogeneity was low (I² <50%) across all meta-analyses, except for the LAIV meta-analyses among children (I² = 79%).

Conclusions

The TIV and LAIV vaccines can provide cross protection against non-matching circulating strains. The point estimates for VE were different for matching versus non-matching strains, with overlapping CIs.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/153/prepub

Title: Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis
Authors: Andrea C Tricco
Ayman Chit
Charlene Soobiah
David Hallett
Genevieve Meier
Maggie H Chen
Mariam Tashkandi
Chris T Bauch
Mark Loeb
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-11-153

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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