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BMC Medicine

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Open Access 01-12-2013 | Debate

Depression as a risk factor for adverse outcomes in coronary heart disease

Authors: Kenneth E Freedland, Robert M Carney

Published in: BMC Medicine | Issue 1/2013

Abstract

Background

Depression is firmly established as an independent predictor of mortality and cardiac morbidity in patients with coronary heart disease (CHD). However, it has been difficult to determine whether it is a causal risk factor, and whether treatment of depression can improve cardiac outcomes. In addition, research on biobehavioral mechanisms has not yet produced a definitive causal model of the relationship between depression and cardiac outcomes.

Discussion

Key challenges in this line of research concern the measurement of depression, the definition and relevance of certain subtypes of depression, the temporal relationship between depression and CHD, underlying biobehavioral mechanisms, and depression treatment efficacy.

Summary

This article examines some of the methodological challenges that will have to be overcome in order to determine whether depression should be regarded as a key target of secondary prevention in CHD.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/131/prepub

Title: Depression as a risk factor for adverse outcomes in coronary heart disease
Authors: Kenneth E Freedland
Robert M Carney
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-11-131

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Depression as a risk factor for adverse outcomes in coronary heart disease

Abstract

Background

Discussion

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Discussion

Summary

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