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BMC Medicine
Published in: BMC Medicine 1/2012

Open Access 01-12-2012 | Commentary

Transcriptome changes in age-related macular degeneration

Authors: S Scott Whitmore, Robert F Mullins

Published in: BMC Medicine | Issue 1/2012

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Abstract

Age-related macular degeneration (AMD) is a debilitating, common cause of visual impairment. While the last decade has seen great progress in understanding the pathophysiology of AMD, the molecular changes that occur in eyes with AMD are still poorly understood. In the current issue of Genome Medicine, Newman and colleagues present the first systematic transcriptional profile analysis of AMD-affected tissues, providing a comprehensive set of expression data for different regions (macula versus periphery), tissues (retina versus retinal pigment epithelium (RPE)/choroid), and disease state (control versus early or advanced AMD). Their findings will serve as a foundation for additional systems-level research into the pathogenesis of this blinding disease.
Please see related article: http://​genomemedicine.​com/​content/​4/​2/​16
Appendix
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Metadata
Title
Transcriptome changes in age-related macular degeneration
Authors
S Scott Whitmore
Robert F Mullins
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2012
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-10-21

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