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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 3/2010

Open Access 01-11-2010 | Poster presentation

Immunoregulatory role of secretory leukocyte protease inhibitor in allergic asthma

Authors: Rafael Marino, Thusanth Thuraisingam, Pierre Camateros, Yong Zhong Xu, Jennifer Henri, Jingxuan Yang, Guoan He, Aihao Ding, Danuta Radzioch

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 3/2010

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Excerpt

Asthma is a complex and multi-factorial inflammatory disease [1]. It is one of the most common chronic diseases among children and adolescents [2]. Secretory leukocyte protease inhibitor (SLPI) has shown higher levels in asthmatic patients and its function as an anti-inflammatory protein has been documented in respiratory diseases [3, 4]. However, its role in the immunomodulation of the response during allergic asthma has not yet been fully elucidated. The aim of this study was to evaluate the role of SLPI in the development of phenotypes associated with allergic asthma, and the effect of resiquimod treatment on the SLPI and the possible mechanisms of action involved in the disease. …
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Blais L, Beauchesne MF, Levesque S: Socioeconomic status and medication prescription patterns in pediatric asthma in Canada. J Adolesc Health. 2006, 38: 607-616. 10.1016/j.jadohealth.2005.02.010.PubMed
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Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA: Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med. 2000, 192: 1587-1600. 10.1084/jem.192.11.1587.PubMedCentralPubMedCrossRef
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Weldon S, McGarry N, Taggart CC, McElvaney NG: The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses. Biochem Soc Trans. 2007, 35: 273-276. 10.1042/BST0350273.PubMedCrossRef
Metadata
Title
Immunoregulatory role of secretory leukocyte protease inhibitor in allergic asthma
Authors
Rafael Marino
Thusanth Thuraisingam
Pierre Camateros
Yong Zhong Xu
Jennifer Henri
Jingxuan Yang
Guoan He
Aihao Ding
Danuta Radzioch
Publication date
01-11-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-6-S3-P24

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