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Open Access 01-11-2010 | Poster presentation

CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis

Authors: Steven Maltby, Carolin Wohlfarth, Michael R Hughes, Kelly M McNagny

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 3/2010

Excerpt

Eosinophil infiltration of gut tissue plays a key role in the pathogenesis of inflammatory bowel diseases (IBD), such as ulcerative colitis. Using a model of allergic asthma, we previously demonstrated that eosinophil migration requires surface expression of the sialomucin CD34, and that Cd34 deletion dampens asthmatic responses in mice. Since CD34 is critical for eosinophil migration, we investigated a role for CD34 in the migration of inflammatory cells into the colon using a mouse model of IBD. …

Title: CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis
Authors: Steven Maltby
Carolin Wohlfarth
Michael R Hughes
Kelly M McNagny
Publication date: 01-11-2010
Publisher: BioMed Central
Published in: Allergy, Asthma & Clinical Immunology / Issue Special Issue 3/2010
Electronic ISSN: 1710-1492
DOI: https://doi.org/10.1186/1710-1492-6-S3-P23

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CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis

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