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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2010

Open Access 01-12-2010 | Review

Rhinitis in the geriatric population

Authors: Jayant M Pinto, Seema Jeswani

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2010

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Abstract

The current geriatric population in the United States accounts for approximately 12% of the total population and is projected to reach nearly 20% (71.5 million people) by 2030[1]. With this expansion of the number of older adults, physicians will face the common complaint of rhinitis with increasing frequency. Nasal symptoms pose a significant burden on the health of older people and require attention to improve quality of life. Several mechanisms likely underlie the pathogenesis of rhinitis in these patients, including inflammatory conditions and the influence of aging on nasal physiology, with the potential for interaction between the two. Various treatments have been proposed to manage this condition; however, more work is needed to enhance our understanding of the pathophysiology of the various forms of geriatric rhinitis and to develop more effective therapies for this important patient population.
Literature
1.
Federal Interagency Forum on Aging-Related Statistics: Older Americans 2008: Key indicators of well-being. Washington, DC: Federal Interagency Forum on Aging-Related Statistics. 2008
2.
Dykewicz M, Fineman S, Skoner D, Nicklas R, Lee R, Blessing-Moore J, Li J, Bernstein I, Berger W, Spector S, Schuller D: Diagnosis and management of rhinitis: Complete guidelines of the Joint Task Force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol. 1998, 81 (5 Pt 2): 478-518. 10.1016/S1081-1206(10)63155-9.PubMed
3.
Chadwick S: Allergic rhinitis in the elderly. Geriatric Otolaryngology. Edited by: Calhoun K, Eibling D. 2006, New York: Taylor & Francis Group, 213-224.
4.
Edelstein D: Aging of the normal nose in adults. Laryngoscope. 1996, 106 (9 Pt 2): 1-25. 10.1097/00005537-199609001-00001.PubMed
5.
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens W, Togias A, Zuberbier T, Baena-Cagnani C, Canonica G, van Weel C, Agache I, Aït-Khaled N, Bachert C, Blaiss M, Bonini S, Boulet L, Bousquet P, Camargos P, Carlsen K, Chen Y, Custovic A, Dahl R, Demoly P, Douagui H, Durham S, van Wijk R, Kalayci O, Kaliner M, Kim Y, Kowalski M, Kuna P, Le L, Lemiere C, Li J, Lockey R, Mavale-Manuel S, Meltzer E, Mohammad Y, Mullol J, Naclerio R, O'Hehir R, Ohta K, Ouedraogo S, Palkonen S, Papadopoulos N, Passalacqua G, Pawankar R, Popov T, Rabe K, Rosado-Pinto J, Scadding G, Simons F, Toskala E, Valovirta E, van Cauwenberge P, Wang D, Wickman M, Yawn B, Yorgancioglu A, Yusuf OM, Zar H, Annesi-Maesano I, Bateman E, Ben Kheder A, Boakye D, Bouchard J, Burney P, Busse W, Chan-Yeung M, Chavannes N, Chuchalin A, Dolen W, Emuzyte R, Grouse L, Humbert M, Jackson C, Johnston S, Keith P, Kemp J, Klossek J, Larenas-Linnemann D, Lipworth B, Malo J, Marshall G, Naspitz C, Nekam K, Niggemann B, Nizankowska-Mogilnicka E, Okamoto Y, Orru M, Potter P, Price D, Stoloff S, Vandenplas O, Viegi G, Williams D: Allergic Rhinitis and its impacts on asthma (ARIA) 2008. Allergy. 2008, 63 (Suppl 86): 7-160.
6.
Wheeler P, Wheeler S: Vasomotor rhinitis. Am Fam Physician. 2005, 72 (6): 1057-62.PubMed
7.
Bousquet J, Fokkens W, Burney P, Durham SR, Bachert C, Akdis C, Canonica G, Dahlen S, Zuberbier T, Bieber T, Bonini S, Bousquet P, Brozek J, Cardell L, Crameri R, Custovic A, Demoly P, van Wijk R, Gjomarkaj M, Holland C, Howarth P, Humbert M, Johnston S, Kauffmann F, Kowalski M, Lambrecht B, Lehmann S, Leynaert B, Lodrup-Carlsen K, Mullol J, Niggemann B, Nizankowska-Mogilnicka E, Papadopoulos N, Passalacqua G, Schünemann H, Simon H, Todo-Bom A, Toskala E, Valenta R, Wickman M, Zock J: Important research questions in allergy and related diseases: Nonallergic rhinitis: A GA2LEN paper. Allergy. 2008, 63 (7): 842-53. 10.1111/j.1398-9995.2008.01715.x.PubMed
8.
Ayars G: Nonallergic rhinitis. Immunol Allergy Clin North Am. 2005, 20 (2): 283-302. 10.1016/S0889-8561(05)70149-1.
9.
Sanico ATA: Noninfectious, nonallergic rhinitis (NINAR): Considerations on possible mechanisms. Am J Rhinol. 1998, 12 (1): 65-72. 10.2500/105065898782103043.PubMed
10.
Yilmaz A, Corey J: Rhinitis in the elderly. Clin Allergy Immunol. 2007, 19: 209-19.
11.
Slavin R: Diagnosis and treatment of rhinitis and sinusitis in the elderly. Immunol Allergy Clin North Am. 1997, 17 (4): 543-56. 10.1016/S0889-8561(05)70329-5.
12.
Wallace D, Dykewicz M, Bernstein D, Bernstein I, Blessing-Moore J, Cox L, Khan D, Lang D, Nicklas R, Oppenheimer J, Portnoy J, Randolph C, Schuller D, Spector S, Tilles S, May K, Miller T, Druce H, Baroody F, Bernstein J, Craig T, Georgitis J, Pawankar R, Rachelefsky G, Settipane R, Skoner D, Stoloff S: The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008, 122: S1-S84. 10.1016/j.jaci.2008.06.003.PubMed
13.
Osman M, Hansell A, Simpson C: Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care. Prim Care Respir J. 2007, 16 (1): 28-35. 10.3132/pcrj.2007.00006.PubMed
14.
Zacharisen M: Rhinitis in children, adolescents, the elderly, and pregnant women. Immunol Allergy Clin North Am. 2000, 20 (4): 424-55.
15.
Simola M, Eino H, Malmberg H: Changes in the skin and nasal sensitivity to allergens and the course of rhinitis. Ann Allergy Asthma Immunol. 1999, 82 (2): 152-6. 10.1016/S1081-1206(10)62589-6.PubMed
16.
Karakaya G, Kalyoncu A: The natural course of atopy determined by skin prick tests in patients with bronchial asthma and/or rhinitis. Allergol Immunopathol (Madr). 2006, 34 (6): 257-62. 10.1157/13095874.
17.
Bellanti J, Azem M, MacDowell-Carneiro A, Tutuncuoglu S, Wallerstedt D: Possible mechanisms of late-life-onset allergic diseases and asthma in the senior citizen. Allergy Asthma Proc. 2000, 21 (5): 267-70. 10.2500/108854100778248287.PubMed
18.
19.
Mathur S, Schwantes E, Jarjour N, Busse W: Age-related changes in eosinophil function in human subjects. Chest. 2008, 133 (2): 412-9. 10.1378/chest.07-2114.PubMedCentralPubMed
20.
Jarvis D, Luczynska C, Chinn S, Potts J, Sunyer J, Janson C, Svanes C, Künzli N, Leynaert B, Heinrich J, Kerkhof M, Ackermann-Liebrich U, Antó J, Cerveri I, de Marco R, Gislason T, Neukirch F, Vermeire P, Wjst M, Burney P: Change in prevalence of IgE sensitization and mean total IgE with age and cohort. J Allergy Clin Immunol. 2005, 16 (3): 675-82.
21.
Settipane R, Charnock D: Epidemiology of rhinitis: Allergic and nonallergic. Clin Allergy Immunol. 2007, 19: 23-34.PubMed
22.
Lal D, Corey J: Vasomotor rhinitis update. Curr Opin Otolaryngol Head Neck Surg. 2004, 12 (3): 243-7. 10.1097/01.moo.0000122310.13359.79.PubMed
23.
Georgitis J: Prevalence and differential diagnosis of chronic rhinitis. Curr Allergy Asthma Rep. 2001, 1 (3): 202-6. 10.1007/s11882-001-0006-6.PubMed
24.
Bachert C, van Cauwenberge P, Olbrecht J, van Schoor J: Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium. Allergy. 2006, 61 (6): 693-8. 10.1111/j.1398-9995.2006.01054.x.PubMed
25.
Benninger M, Benninger R: The impact of allergic rhinitis on sexual activity, sleep, and fatigue. Allergy Asthma Proc. 2009, 30 (4): 358-65. 10.2500/aap.2009.30.3244.PubMed
26.
Feinsilver S: Sleep in the elderly. What is normal?. Clin Geriatr Med. 2003, 19 (1): 177-88. 10.1016/S0749-0690(02)00064-2.PubMed
27.
Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. Lancet. 1999, 345 (9188): 1429-35.
28.
Trenell M, Marshall N, Rogers N: Sleep and metabolic control: Waking to a problem?. Clin Exp Pharmacol Physiol. 2007, 34: 1-9. 10.1111/j.1440-1681.2007.04541.x.PubMed
29.
Byles J, Mishra G, Harris M, Nair K: The problems of sleep for older women: Changes in health outcomes. Age Ageing. 2003, 32 (2): 154-63. 10.1093/ageing/32.2.154.PubMed
30.
Kim J, Stewart R, Kim S, Yang SJ, Shin I, Yoon J: Insomnia, depression, and physical disorders in late life: A 2-year longitudinal community study in Koreans. Sleep. 2009, 32 (9): 1221-8.PubMedCentralPubMed
31.
Zanocchi M, Ponzetto M, Spada S, Risso R, Aimar T, Maero B, Giona E, Fabris F: Sleep disorders in the aged. Minerva Med. 1999, 90 (11-12): 421-7.PubMed
32.
Dew M, Hoch C, Buysse D, Monk T, Begley A, Houck P, Hall M, Kupfer D, Reynolds C: Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003, 65 (1): 63-73. 10.1097/01.PSY.0000039756.23250.7C.PubMed
33.
Lucchetti M, Corsonello A, Gattaceca R: Environmental and social determinants of aging perception in metropolitan and rural areas of Southern Italy. Arch Gerontol Geriatr. 2008, 46 (3): 349-57. 10.1016/j.archger.2007.05.009.PubMed
34.
35.
Rydén O, Andersson B, Andersson M: Disease perception and social behaviour in persistent rhinitis: a comparison between patients with allergic and nonallergic rhinitis. Allergy. 2004, 59 (4): 461-4. 10.1046/j.1398-9995.2003.00331.x.PubMed
36.
Kalpaklioglu A, Kavut A: Allergic and nonallergic rhinitis: Can we find the differences/similarities between the two pictures?. J Asthma. 2009, 46 (5): 481-5. 10.1080/02770900902849897.PubMed
37.
Aspinall R, Andrew D: Thymic involution in aging. J Clin Immunol. 2000, 20 (4): 250-6. 10.1023/A:1006611518223.PubMed
38.
Ostan R, Bucci L, Capri M, Salvioli S, Scurti M, Pini E, Monti D, Franceschi C: Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation. 2008, 15 (4-6): 224-40. 10.1159/000156466.PubMed
39.
Uciechowski P, Kahmann L, Plümäkers B, Malavolta M, Mocchegiani E, Dedoussis G, Herbein G, Jajte J, Fulop T, Rink L: TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation. Exp Gerontol. 2008, 43 (5): 493-8. 10.1016/j.exger.2007.11.006.PubMed
40.
Hwang K, Kim H, Kang I: Aging and human CD4(+) regulatory T cells. Mech Ageing Dev. 2009, 130 (8): 509-17. 10.1016/j.mad.2009.06.003.PubMedCentralPubMed
41.
Patterson C: The aging nose: Characteristics and correction. Otolaryngol Clin North Am. 1980, 13 (2): 275-88.PubMed
42.
Reiss M, Reiss G: Rhinitis in old age. Praxis. 2002, 91 (9): 353-8. 10.1024/0369-8394.91.9.353.PubMed
43.
Schrödter S, Biermann E, Halata Z: Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate. Anat Embryo. 2003, 207: 19-27. 10.1007/s00429-003-0326-5.
44.
Bende M: Blood flow with 133 Xe in human nasal mucosa in relation to age, sex and body position. Acta Oto-laryngologica. 1983, 96 (1-2): 175-9. 10.3109/00016488309132889.PubMed
45.
Lindemann J, Sannwald D, Wiesmiller K: Age-related changes in intranasal air conditioning in the elderly. Laryngoscope. 2008, 188: 8-1472.
46.
Calhoun K, House W, Hokanson J, Quinn F: Normal nasal airway resistance in noses of different sizes and shapes. Otolaryngol Head Neck Surg. 1990, 130 (4): 605-9.
47.
Vig P, Zajac D: Nasal resistance and breathing mode. Cleft Palate Craniofac J. 1994, 31 (1): 81-2.PubMed
48.
Kalmovich L, Elad D, Zaretsky U, Adunsky A, Chetrit A, Sadetzki S, Segal S, Wolf M: Endonasal geometry changes in elderly people: Acoustic rhinometry measurements. Gerontol A Biol Sci Med Sci. 2005, 60 (3): 396-8.
49.
Nappi C, Sardo A, Guerra G, Bifulco G, Testa D, Di Carlo C: Functional and morphologic evaluation of the nasal mucosa before and after hormone therapy in postmenopausal women with nasal symptoms. Fertility and Sterility. 2003, 80 (3): 669-71. 10.1016/S0015-0282(03)00975-0.PubMed
50.
Philpott C, Wild D, Wolstensholme C, Murty G: The presence of ovarian hormone receptors in the nasal mucosa and their relationship to nasal symptoms. Rhinology. 2008, 46 (3): 221-5.PubMed
51.
Ho J, Chan K, Hu W, Lam WK, Zheng L, Tipoe GL, Sun J, Leung R, Tsang K: The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia. Am J Respir Crit Care Med. 2001, 164 (4): 938-3.
52.
Kirtsreesakul V, Somjareonwattana P, Ruttanaphol S: The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope. 2009, 119 (8): 1458-62. 10.1002/lary.20146.PubMed
53.
Seiberling K, Conley D: Aging and olfactory and taste function. Otolaryngol Clin North Am. 2004, 37 (6): 1209-28. 10.1016/j.otc.2004.06.006.PubMed
54.
Apter A, Mott A, Frank M, Clive J: Allergic rhinitis and olfactory loss. Ann Allergy Asthma Immunol. 1995, 75 (4): 311-6.PubMed
55.
Pinto J, Jeswani S, Reder L, Wang J, Perez R, DeTineo M, Baroody F, Naclerio R: Olfactory cleft inflammation is present in seasonal allergic rhinitis and improves with intranasal steroids abstract. J Allergy Clin Immunol. 2008, 121 (2): S277-10.1016/j.jaci.2007.12.1146.
56.
Simola M, Malmberg H: Sense of smell in allergic and nonallergic rhinitis. Allergy. 1998, 53 (2): 190-4. 10.1111/j.1398-9995.1998.tb03869.x.PubMed
57.
Hansen J, Klimek L, Hörmann K: Pharmacological management of allergic rhinitis in the elderly: Safety issues with oral antihistamines. Drugs Aging. 2005, 22 (4): 289-96. 10.2165/00002512-200522040-00002.PubMed
58.
Haberal I, Corey J: The role of leukotrienes in nasal allergy. Otolaryngol Head Neck Surg. 2003, 129 (3): 274-9. 10.1016/S0194-5998(03)00601-6.PubMed
59.
Skoner D: Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001, 108 (1 Suppl): S2-8. 10.1067/mai.2001.115569.PubMed
60.
Togias A: Unique mechanistic features of allergic rhinitis. J Allergy Clin Immunol. 2000, 105 (6 Suppl 1): 599-604. 10.1067/mai.2000.106885.
61.
Hansen I, Klimek L, Mösges R, Hörmann K: Mediators of inflammation in the early and the late phase of allergic rhinitis. Curr Opin Allergy Clin Immunol. 2004, 4 (3): 159-63. 10.1097/00130832-200406000-00004.PubMed
62.
Mahmoudi M: Prevalance of allergic diseases in children, adults, and the elderly. Asthma and Allergy: Practical Diagnosis and Management. Edited by: Shanahan J, Naglieri C. 2008, McGraw-Hill Professional, 18-20. 1
63.
Jackola D, Pierson-Mullany L, Daniels L, Corazalla E, Rosenberg A, Blumenthal M: Robustness into advanced age of atopy-specific mechanisms in atopy-prone families. J Gerontol A Biol Sci Med Sci. 2003, 58 (2): 99-107.PubMed
64.
Mediaty A, Neuber K: Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis. Immun Ageing. 2005, 2 (1): 9-10.1186/1742-4933-2-9.PubMedCentralPubMed
65.
Greiner A, Meltzer E: Pharmacologic rationale for treating allergic and nonallergic rhinitis. J Allergy Clin Immunol. 2006, 118 (5): 985-98. 10.1016/j.jaci.2006.06.029.PubMed
66.
Smith T: Vasomotor rhinitis is not a wastebasket diagnosis. Arch Otolaryngol Head Neck Surg. 2003, 129 (5): 584-7. 10.1001/archotol.129.5.584.PubMed
67.
Salib R, Harries P, Nair S, Howarth P: Mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Clin Exp Allergy. 2008, 38 (3): 393-404. 10.1111/j.1365-2222.2007.02926.x.PubMed
68.
Cervin A, Onnerfalt J, Edcinsson L, Grundemar L: Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose. Am J Respir Crit Care Med. 1999, 160 (5 Pt 1): 1724-8.PubMed
69.
Shi G, Li X: The roles of three peptides in the pathogenesis of vasomotor rhinitis. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006, 20 (17): 777-9.PubMed
70.
Baraniuk J, Merck S: Nasal reflexes: Implications for exercise, breathing, and sex. Curr Allergy Asthma Rep. 2008, 8 (2): 147-53. 10.1007/s11882-008-0025-7.PubMedCentralPubMed
71.
Cardell L, Andersson M, Cervin A, Davidsson A, Hellgren J, Holmström M, Lundblad L, Stierna P, Stjärne P, Adner M, SRFA study group: Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis. Allergy. 2009, 64 (9): 1301-8. 10.1111/j.1398-9995.2009.02009.x.PubMed
72.
Baraniuk J: Neural regulation of mucosal function. Pulm Pharmacol Ther. 2008, 21 (3): 442-8. 10.1016/j.pupt.2007.06.006.PubMedCentralPubMed
73.
Ballentine N: Polypharmacy in the elderly: Maximizing benefit, minimizing harm. Crit Care Nurs Q. 2008, 31 (1): 40-5.PubMed
74.
Kaufman D, Kelly J, Rosenberg L, Anderson T, Mitchell A: Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. JAMA. 2002, 287 (3): 337-44. 10.1001/jama.287.3.337.PubMed
75.
Bateman N, Woolford T: The rhinological side-effects of systemic drugs. Clin Otolaryngol Allied Sci. 2003, 28 (5): 381-5. 10.1046/j.1365-2273.2003.00712.x.PubMed
76.
Slavin R: Allergic rhinitis: Managing the adult spectrum. Allergy Asthma Proc. 2006, 27 (1): 9-11.PubMed
77.
Jordan J, Mabry R: Geriatric rhinitis: What it is, and how to treat it. Geriatrics. 1998, 53 (76): 81-4.
78.
Mehrotra R, Singhal J, Kawatra M, Gupta S, Singh M: Pre and post-treatment histopathological changes in atrophic rhinitis. J Pathol Microbiol. 2005, 48 (3): 310-3.
79.
Garcia G, Bailie N, Martins D, Kimbell J: Atrophic rhinitis: A CFD study of air conditioning in the nasal cavity. J Appl Physiol. 2007, 103 (3): 1082-92. 10.1152/japplphysiol.01118.2006.PubMed
80.
Hirt R, Paulsen F, Neumann K, Knipping S: Immunocytochemical detection of caspase 3 in various diseases of human nasal mucosa. HNO. 2009, 57 (5): 466-72. 10.1007/s00106-009-1905-4.PubMed
81.
Ly T, deShazo R, Olivier J, Stringer S, Daley W, Stodard C: Diagnostic criteria for atrophic rhinosinusitis. Am J Med. 2009, 122 (8): 747-53. 10.1016/j.amjmed.2008.12.025.PubMed
82.
Dutt S, Kameswaran M: The aetiology and management of atrophic rhinitis. J Laryngol Otol. 2005, 120 (6): 489-502.
83.
Busse P: Allergic respiratory disease in the elderly. Am J Med. 2007, 120 (6): 485-502. 10.1016/j.amjmed.2006.03.024.
84.
85.
Schwartz H, Arnold J, Strohl K: Occupational allergic rhinitis reaction to psyllium. J Occup Med. 1989, 3: 624-6. 10.1097/00043764-198907000-00015.
86.
Holgate S, Banik A: Epidemiology of Asthma. New and Exploratory Therapeutic Agents for Asthma. Edited by: Yeadon M, Diamantas Z. 2000, New York: Marcel Dekker, Inc, 1-26.
87.
King M, Lockey R: Allergen prick-puncture skin testing in the elderly. Drugs Aging. 2003, 20 (14): 1011-7. 10.2165/00002512-200320140-00001.PubMed
88.
Dykewicz M: Clinical approach to diagnosis and treatment of nonallergic rhinitis. Clin Allergy Immunol. 2007, 19: 335-50.PubMed
89.
Lloyd G, Lund V, Scadding G: CT of the paranasal sinuses and functional endoscopic surgery: A critical analysis of 100 symptomatic patients. J Laryngol Otol. 1991, 105 (3): 181-5. 10.1017/S0022215100115300.PubMed
90.
Osguthorpe J: Adult rhinosinusitis: Diagnosis and management. Am Fam Physician. 2001, 63 (1): 69-76.PubMed
91.
Hilberg O: Objective measurement of nasal airway dimensions using acoustic rhinometry: Methodological and clinical aspects. Allergy. 2002, 57 (Suppl 70): 5-39. 10.1046/j.0908-665x.2001.all.doc.x.PubMed
92.
Loehrl T, Smith T, Darling R, Torrico L, Prieto T, Shaker R, Toohill R, Jaradeh S: Autonomic dysfunction, vasomotor rhinitis and extraesophageal manifestations of gastroesophageal reflux. Otolaryngol Head Neck Surg. 2002, 126 (4): 382-7. 10.1067/mhn.2002.123857.PubMed
93.
Rogkakou A, Guerra L, Massacane P, Baiardini I, Baena-Cagnani R, Zanella C, Canonica G, Passalacqua G: Effects On symptoms and quality of life of hypertonic saline nasal spray added to antihistamine in persistent allergic rhinitis--a randomized controlled study. Eur Ann Allergy Clin Immunol. 2005, 37 (9): 353-6.PubMed
94.
Rabago D, Pasic T, Zgierska A, Mundt M, Barrett B, Maberry R: The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 2005, 133 (1): 3-8. 10.1016/j.otohns.2005.03.002.PubMed
95.
Johnsen J, Bratt B, Michel-Barron O, Glennow C, Petruson B: Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa. Arch Otolaryngol Head Neck Surg. 2001, 127 (11): 1353-6.PubMed
96.
Plaut M, Valentine M: Clinical practice:Allergic rhinitis. N Engl J Med. 2005, 353 (18): 1934-44. 10.1056/NEJMcp044141.PubMed
97.
McCue J: Safety of antihistamines in the treatment of allergic rhinitis in the elderly. Arch Fam Med. 1996, 5 (8): 464-8. 10.1001/archfami.5.8.464.PubMed
98.
Holgate S, Canonica G, Simons F, Taglialatela M, Tharp M, Timmerman H, Yanai K: Consensus group on new generation antihistamines (CONGA): present status and recommendations. Clin Exp Allergy. 2003, 33: 1305-24. 10.1046/j.1365-2222.2003.01769.x.PubMed
99.
Golden S, Craig T: Efficacy and safety of azelastine nasal spray for the treatment of allergic rhinitis. J Am Osteopath Assoc. 1999, 99 (7 Suppl): S7-S12.PubMed
100.
Peter G, Romeis P, Borbe H, Büker K, Riethmüller-Winzen H: Tolerability and pharmacokinetics of single and multiple doses of azelastine hydrochloride in elderly volunteers. Arzneimittelforschung. 1995, 45 (5): 576-81.PubMed
101.
McNeely W, Wiseman L, Intranasal azelastine: A review of its efficacy in the management of allergic rhinitis. Drugs. 1998, 56 (1): 91-114. 10.2165/00003495-199856010-00011.PubMed
102.
Bernstein J: Azelastine hydrochloride: A review of pharmacology, pharmacokinetics, clinical efficacy and tolerability. Curr Med Res Opin. 2007, 23 (10): 2441-52. 10.1185/030079907X226302.PubMed
103.
Berger W: Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis. Expert Opin Drug Metab Toxicol. 2009, 5 (1): 91-102. 10.1517/17425250802670474.PubMed
104.
Bernstein J, Prenner B, Ferguson B, Portnoy J, Wheeler W, Sacks H: Double-blind, placebo-controlled trial of reformulated azelastine nasal spray in patients with seasonal allergic rhinitis. Am J Rhinol Allergy. 2009, 23 (5): 512-7. 10.2500/ajra.2009.23.3396.PubMed
105.
Tan R, Corren J: Optimum treatment of rhinitis in the elderly. Drugs Aging. 1995, 7 (3): 168-75. 10.2165/00002512-199507030-00002.PubMed
106.
Grossman J, Gopalan G: Efficacy and safety of mometasone furoate spray in elderly subjects with perennial allergic rhinitis [abstract]. J Allergy Clin Immunol. 2009, 123 (2 Suppl 1): S271-10.1016/j.jaci.2008.12.1047.
107.
Benninger M, Ahmad N, Marple B: The safety of intranasal steroids. Otolaryngol Head Neck Surg. 2003, 129 (6): 739-50. 10.1016/j.otohns.2003.10.001.PubMed
108.
Little D: Geriatric rhinitis: Under-diagnosed and undertreated. Geriatrics and Aging. 2005, 8 (5): 52-3.
109.
Horak F, Zieglmayer P, Zieglmayer R, Lemell P, Yao R, Staudinger H, Danzig M: A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna challenge chamber. Ann Allergy Asthma Immunol. 2009, 102 (2): 116-20. 10.1016/S1081-1206(10)60240-2.PubMed
110.
Li J, Tripathi R, Tripathi B: Drug-induced ocular disorders. Drug Saf. 2008, 31 (2): 127-41. 10.2165/00002018-200831020-00003.PubMed
111.
Rosenwasser L: Treatment of allergic rhinitis. Am J Med. 2002, 113 (Suppl 9A): 17S-24S. 10.1016/S0002-9343(02)01433-X.PubMed
112.
Graf P, Juto J: Decongestion effect and rebound swelling of the nasal mucosa during 4-week use of oxymetazoline. ORL J Otorhinolaryngol Relat Spec. 1994, 56 (3): 157-60.PubMed
113.
Busse W: The role of leukotrienes in asthma and allergic rhinitis. Clin Exp Allergy. 1996, 26 (8): 868-79. 10.1111/j.1365-2222.1996.tb00621.x.PubMed
114.
Wilson A, O'Byrne P, Parameswaran K: Leukotriene receptor antagonists for allergic rhinitis: A systematic review and meta-analysis. Am J Med. 2004, 116 (5): 338-44. 10.1016/j.amjmed.2003.10.030.PubMed
115.
Virchow J, Bachert C: Efficacy and safety of montelukast in adults with asthma and allergic rhinitis. Respir Med. 2006, 100 (11): 1952-9. 10.1016/j.rmed.2006.02.026.PubMed
116.
Ratner P, Ehrlich P, Fineman S, Meltzer E, Skoner D: Use of intranasal cromolyn sodium for allergic rhinitis. Mayo Clin Proc. 2002, 77 (4): 350-4. 10.4065/77.4.350.PubMed
117.
Eidelman F, Darzentas N: Efficacy of allergy immunotherapy in the elderly. J Allergy Clin Immunol. 2000, 105 (1 Pt 2): S313-10.1016/S0091-6749(00)91348-4.
118.
Asero R: Efficacy of injection immunotherapy with ragweed and birch pollen in elderly patients. Int Arch Allergy Immunol. 2004, 135 (4): 332-5. 10.1159/000082328.PubMed
119.
Ciprandi G: Treatment of nonallergic perennial rhinitis. Allergy. 2004, 59 (Suppl 76): 16-22. 10.1111/j.0108-1675.2004.00390.x.PubMed
120.
Banov C, Lieberman P, Vasomotor Rhinitis Study Groups: Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann Allergy Asthma Immunol. 2001, 86 (1): 28-35. 10.1016/S1081-1206(10)62352-6.PubMed
121.
Settipane R, Lieberman P: Update on nonallergic rhinitis. Ann Allergy Asthma Immunol. 2001, 86 (5): 494-507. 10.1016/S1081-1206(10)62896-7.PubMed
122.
Jacobs R, Lieberman P, Kent E, Silvey M, Locantore N, Philpot E: Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. Allergy Asthma Proc. 2009, 30 (2): 120-7. 10.2500/aap.2009.30.3206.PubMed
123.
124.
Chen J, Kong W, Zhou Y, Xiang J, Shu H, Shi Q, Tan H: Efficacy evaluation of polysaccharide nucleic acid-fraction of BCG on vasomotor rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008, 22 (5): 201-3.PubMed
125.
Naclerio R: Optimizing treatment options. Clin Exp Allergy. 1998, 28 (Suppl 6): 54-9. 10.1046/j.1365-2222.1998.0280s6054.x.PubMed
126.
Naumann M, Jost W: Botulinum toxin treatment of secretory disorders. Mov Disord. 2004, 19 (Suppl 8): S137-41. 10.1002/mds.20067.PubMed
127.
Laing T, Laing M, O'Sullivan S: Botulinum toxin for treatment of glandular hypersecretory disorders. J Plast Reconstr Aesthet Surg. 2008, 61 (9): 1024-8. 10.1016/j.bjps.2008.03.023.PubMed
128.
Bassichis B, Marple B: Dry mouth and nose in the older patient. What every PCP should know. Geriatrics. 2002, 57 (10): 22-4.PubMed
129.
Busaba N, Hossain M: Clinical outcomes of septoplasty and inferior turbinate reduction in the geriatric veterans' population. Am J Rhinol. 2004, 18 (6): 343-7.PubMed
130.
Colclasure J, Gross C, Kountakis S: Endoscopic sinus surgery in patients older than sixty. Otolaryngol Head Neck Surg. 2004, 131 (6): 946-9. 10.1016/j.otohns.2004.06.710.PubMed
131.
Ramadan H, VanMetre R: Endoscopic sinus surgery in geriatric population. Am J Rhinol. 2004, 18 (2): 125-7.PubMed
132.
Reh D, Mace J, Robinson J, Smith T: Impact of age on presentation of chronic rhinosinusitis and outcomes of endoscopic sinus surgery. Am J Rhinol. 2007, 21 (2): 207-13. 10.2500/ajr.2007.21.3005.PubMed
Metadata
Title
Rhinitis in the geriatric population
Authors
Jayant M Pinto
Seema Jeswani
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2010
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/1710-1492-6-10

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