Published in:
Open Access
01-12-2014 | Meeting abstract
B cell Semaphorin 4c expression mitigates the airway hyperresponsiveness and acute inflammation which characterize allergic airway disease
Authors:
Alex Lei, Di Xue, Marylin Desjardins, Marianne Beland, Bruce Mazer
Published in:
Allergy, Asthma & Clinical Immunology
|
Special Issue 2/2014
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Excerpt
Semaphorin signaling proteins, initially examined in the context of neuronal axon development, have recently been implicated as regulators of immune cell migration. Our laboratory has determined that expression of Semaphorin 4C (Sema4C) is strongly induced on B cells exposed to Th2 stimulation, and we seek to elucidate its mechanism of controlling allergic airway disease. …