Published in:
Open Access
01-03-2014 | Meeting abstract
Migration of the contractile phenotype of human airway smooth muscle cells in response to supernatants from rhinovirus infected human bronchial epithelial cells
Authors:
Abid Qureshi, Sami Shariff, Sergei Nikitenko, Jason Arnason, Chris Shelfoon, Suzanne Traves, David Proud, Richard Leigh
Published in:
Allergy, Asthma & Clinical Immunology
|
Special Issue 1/2014
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Excerpt
Human rhinovirus (HRV) infections during early childhood are associated with a significantly increased risk of developing asthma in subsequent years [
1]. There is published evidence that airway remodeling is present in pre-school children, often before the diagnosis of asthma is established [
1]. It is thought that this increased risk relates to the fact that HRV infections facilitate airway remodeling in asthma [
2]. A feature of airway remodeling is the proximity of airway smooth muscle (ASM) to the subepithelial region among other pathological changes [
3]. Smooth muscle is also known to exist in two distinct phenotypes: secretory and contractile [
4]. We have recently shown that HRV infection of Human Bronchial Epithelial Cells (HBEC), both
in vitro and
in vivo, results in the up-regulation of a number of airway remodeling mediators [
5]. We now sought to determine which ASM phenotype (contractile or secretory) results in migration to supernatants from HRV infected HBE cells. …