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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2014

Open Access 01-03-2014 | Meeting abstract

MHC class II deficiency in the Dene native population: a case report highlighting pitfalls in diagnosis and treatment

Authors: Alex Lyttle, Chaim Roifman, Harjit Dadi, Nicola Wright, Fotini Kavadas

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 1/2014

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Excerpt

Bare lymphocyte syndrome (BLS) is a rare, hereditary immunodeficiency characterized by the absence of major histocompatibility complex (MHC) class II leading to a form of severe combined immunodeficiency (SCID). Here we present a case introducing BLS in a novel population and emphasize some of the difficulties faced in diagnosing and treating this condition. …
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Krawczyk M, Reith W: Regulation of MHC class II expression, a unique regulatory system identified by the study of primary immunodeficiency disease. Tissue Antigens. 2006, 67: 183-197.CrossRefPubMed
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Somech : T-cell receptor excision circles in primary immunodeficiencies and other T-cell immune disorders. Curr opinion Allergy Clin Immunol. 2011, 11: 517-524.CrossRef
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Siepermann : MHC class II deficiency cured by unrelated mismatched umbilical cord blood transplantation: case report and review of 68 cases in the literature. Pediatric Transplantation. 2011, 15 (4): E80-6.CrossRefPubMed
Metadata
Title
MHC class II deficiency in the Dene native population: a case report highlighting pitfalls in diagnosis and treatment
Authors
Alex Lyttle
Chaim Roifman
Harjit Dadi
Nicola Wright
Fotini Kavadas
Publication date
01-03-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-10-S1-A1

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