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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2014

Open Access 01-12-2014 | Research

Influence of the programmed cell death of lymphocytes on the immunity of patients with atopic bronchial asthma

Authors: Cyrille Alode Vodounon, Christophe Boni Chabi, Ylia Valerevna Skibo, Vincent Ezin, Nicolas Aikou, Simeon Oloni Kotchoni, Simon Ayeleroun Akpona, Lamine Baba-Moussa, Zinaida Ivanovna Abramova

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2014

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Abstract

Background

Fairly recent data highlight the role of programmed cell death and autoimmunity, as potentially important factors in the pathogenesis of chronic obstructive airway diseases. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity.

Method

The study was performed on the peripheral blood of patients with atopic bronchial asthma with different severity. The Immunological aspects were determined with ELISA, the fluorimetric method and the method of precipitation with polyethylene glycol. And the quantification of the parameters of the programmed cell death was performed by the method of flow cytometry and electron microscopy method.

Results

The data obtained from morphological and biochemical parameters show the deregulation of Programmed Death of lymphocytes of patients with atopic bronchial asthma but individual for each group of patients. This dysfunction might induce the secretion of autoantibodies against DNA. This could explain the accumulation of circulating immune complex with average size considered as the most pathogenic in patients with bronchial asthma especially in the patients of serious severity. It should be noted that Patients with bronchial asthma of mild and severe severity had different way and did not have the same degree of deficiency of the immune system.

Conclusion

These data suggested that apoptotic factor of lymphocytes may play an important role in controlling immunity of patients with atopic bronchial asthma.
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Metadata
Title
Influence of the programmed cell death of lymphocytes on the immunity of patients with atopic bronchial asthma
Authors
Cyrille Alode Vodounon
Christophe Boni Chabi
Ylia Valerevna Skibo
Vincent Ezin
Nicolas Aikou
Simeon Oloni Kotchoni
Simon Ayeleroun Akpona
Lamine Baba-Moussa
Zinaida Ivanovna Abramova
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2014
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/1710-1492-10-14

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