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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2009

Open Access 01-12-2009 | Case Report

Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?

Authors: Catalina Matiz, Polly J Ferguson, Andrea Zaenglein, Brandt Groh, Catherine April Bingham

Published in: Pediatric Rheumatology | Issue 1/2009

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Abstract

Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with multicentric reticulohistiocytosis. However, pathology of the xanthomatous lesions was more suggestive of papular xanthoma, a disease that is not associated with arthritis. Based on her presentation and the negative lipid workup, she was treated for presumed multicentric reticulohistiocytosis. Multiple treatment strategies were utilized, with improvement on a combination of infliximab, methotrexate, and prednisone. We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis.
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Metadata
Title
Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?
Authors
Catalina Matiz
Polly J Ferguson
Andrea Zaenglein
Brandt Groh
Catherine April Bingham
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue 1/2009
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-7-15

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